Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Margaret G. Wong"'
Autor:
Margaret G. Wong, Reginald F. Cross
Publikováno v:
Chromatographia. 58:427-437
A series of eighteen peptides have been modelled. Of the 380 low-energy viable conformers generated, 64 were selected, with 2–5 per peptide representing the range of structures and size. Using the results of previous investigations of this peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc052c7f4105dc30b7254c2483e9f9d5
https://doi.org/10.1365/s10337-003-0084-9
https://doi.org/10.1365/s10337-003-0084-9
Autor:
Margaret G. Wong, Reginald F. Cross
Publikováno v:
Chromatographia. 58:439-447
From the published electrophoretic data for a set of 58 peptides at pH 2.5 we have determined the excess hydration required to correct the deviations of the 31 higher-charged peptides from the Offord plot for the 27 singly-charged peptides. These val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21cdc2e9ad01e3f862265f28c667a928
https://doi.org/10.1365/s10337-003-0085-8
https://doi.org/10.1365/s10337-003-0085-8
Autor:
Emanuela Gancia, William R. Pitt, John Gary Montana, Margaret G. Wong, Benjamin G Tehan, Edward John Lloyd, David T. Manallack
Publikováno v:
Quantitative Structure-Activity Relationships. 21:457-472
The electronic properties of small molecules can be calculated quickly and with a reasonable degree of accuracy using semiempirical QM methods. In this study a set of QM properties derived from frontier electron theory have been used to produce a pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec2fa6c60566a0bc8c8b15c6145e5f95
https://doi.org/10.1002/1521-3838(200211)21:5<457::aid-qsar457>3.0.co
https://doi.org/10.1002/1521-3838(200211)21:5<457::aid-qsar457>3.0.co
Autor:
Edward John Lloyd, Emanuela Gancia, David T. Manallack, Margaret G. Wong, Benjamin G Tehan, William R. Pitt
Publikováno v:
Quantitative Structure-Activity Relationships. 21:473-485
The pK a of a compound directly influences its biopharmaceutical profile. This article describes the development of a method for estimating pK a values for a number of nitrogen containing chemical structures using semiempirical QM properties derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4635e472b66f79376e511e287f09a6
https://doi.org/10.1002/1521-3838(200211)21:5<473::aid-qsar473>3.0.co
https://doi.org/10.1002/1521-3838(200211)21:5<473::aid-qsar473>3.0.co
Publikováno v:
Molecular Simulation. 28:865-888
A number of theoretical dopaminergic D 2 models were constructed using comparative modelling techniques. The models constructed were based on the recently published crystal structure of rhodopsin. D 2 models were constructed without any ligands bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35a8d000e317d9a81c6e44d287ad7a1
https://doi.org/10.1080/0892702021000002548
https://doi.org/10.1080/0892702021000002548
Publikováno v:
Current Pharmaceutical Design. 8:1547-1570
Since ancient times the operation of the brain has elicited more than usual interest. Data mining of the human genome is revealing that many CNS abnormalities have a genetic component. As yet this information can not be used directly to cure or ameli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec0922c59f7baf274747e8d73c6cf95
https://doi.org/10.2174/1381612023394250
https://doi.org/10.2174/1381612023394250
Autor:
Reginald F. Cross, Margaret G. Wong
Publikováno v:
Chromatographia. 53:431-436
Eighteen peptides have been modeled. From the volumetric data derived, and published mobilities, the relationship between electrophoretic mobility (μep) and the hydrodynamic radius(r) has been examined. Objective testing with respect to size has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc59fd7252125f5f346c874e8bb80a49
https://doi.org/10.1007/bf02491080
https://doi.org/10.1007/bf02491080
Autor:
Anna E. Salinas, Margaret G. Wong
Publikováno v:
Current Medicinal Chemistry. 6:279-309
Abstract: The Glutathione S-transferases (GSTs) form a group of multi-gene isoenzymes involved in the cellular detoxification of both xenobiotic and endobiotic compounds. GSTs have been divided into a number of subclasses, alpha (α), mu {μ), pi (π
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96275f08dfd0ad2e80dd88a66da695ba
https://doi.org/10.2174/0929867306666220208213032
https://doi.org/10.2174/0929867306666220208213032
Publikováno v:
European Journal of Medicinal Chemistry. 31:651-662
Summary A series of 2,3-disubstituted-6-alkoxyimidazo[1,2-b]pyridazines has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d58f26fdc8604ccaffc5ce0a9f63e4c
https://doi.org/10.1016/0223-5234(96)85873-9
https://doi.org/10.1016/0223-5234(96)85873-9
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 269:193-200
The interaction of a novel series of heterocyclic amino alcohols with the sigma receptor site was assessed using radioligand binding and computerized molecular modelling. All heterocyclic amino alcohols, like the structurally related ifenprodil, full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75559583d754ce5b862e99bc20767082
https://doi.org/10.1016/0922-4106(94)90086-8
https://doi.org/10.1016/0922-4106(94)90086-8