Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Margaret G. Ménache"'
Autor:
Maceij Wachulec, Karin Rudolph, Matthew J. Kluger, Wieslaw Kozak, Rogene F. Henderson, Anna Kozak, Carole A. Conn, Edward B. Barr, Karol Dokladny, Margaret G. Ménache
Publikováno v:
Toxicology and Applied Pharmacology. 184:77-81
Coexposure to subclinical levels of nerve gas and to heat stress may have induced some of the clinical symptoms of the Gulf War Syndrome. We tested the hypothesis that single or repeated subclinical exposure to sarin, particularly under conditions of
Autor:
Edward B. Barr, Mohan L. Sopori, Rogene F. Henderson, Roma Kalra, Yohannes Tesfaigzi, Connie R. Clark, Carole A. Conn, Thomas H. March, Deborah C. Mash, Margaret G Ménache, Walter B. Blackwell
Publikováno v:
Toxicology and Applied Pharmacology. 184:67-76
The purpose of this study was to determine whether exposure to levels of sarin causing no overt clinical signs would cause more subtle, adverse health effects that persisted after the exposure ended. Inhalation exposures of male Fischer 344 rats to 0
Autor:
Judith T. Zelikoff, Christine Nadziejko, Margaret G. Ménache, Maureen Sisco, Richard B. Schlesinger, Jean F. Regal, Terry Gordon, Mitchell D. Cohen
Publikováno v:
Inhalation Toxicology. 14:431-457
While acute exposures to ozone (O(3)) can alter airway responsiveness, effects from long-term exposures at low concentrations are less clear. This study assessed whether such exposures could induce nonspecific hyperresponsiveness in nonatopic (nonsen
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 7:867-890
This study presents an improved version of a published biomathematical model, the Random Coincidence Model-Radiation Adapted (RCM-RA). That model describes how cancer mortality increases as dose rate increases in the high-dose rate range, as well as
Autor:
Anna Kozak, Wieslaw Kozak, Mohan L. Sopori, Edward B. Barr, Matthew J. Kluger, Yohannes Tesfaigzi, Karin Rudolph, Deborah C. Mash, Karol Dokladny, Connie R. Clark, Seddigheh Razani-Boroujerdi, Shashi P. Singh, Thomas H. March, Carole A. Conn, Rogene F. Henderson, Maceij Wachulec, Raymond J. Langley, Margaret G Ménache, Walter B. Blackwell, Roma Kalra
Publikováno v:
Toxicology and Industrial Health. 17:294-297
Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The ra
Autor:
Maciej Wachulec, Pope L. Moseley, Anna Kozak, Karol Dokladny, Erik S. Wallen, Matthew J. Kluger, Margaret G. Ménache, Wieslaw Kozak
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 280:R338-R344
We have previously reported that heat conditioning augments lipopolysaccharide (LPS)-induced fever in rats, which is accompanied by an accumulation of heat shock protein (HSP) in the liver and the reduction of the plasma level of tumor necrosis facto
Autor:
Thomas H. March, C. H. Hobbs, Fletcher F. Hahn, Gregory L. Finch, Edward B. Barr, Margaret G Ménache, Kristen J. Nikula
Publikováno v:
Toxicological Sciences. 51:289-299
Cigarette smoke (CS) causes pulmonary emphysema in humans, but results of previous studies on CS-exposed laboratory animals have been equivocal and have not clearly demonstrated progression of the disease. In this study, morphometry and histopatholog
Autor:
Kent E, Pinkerton, Yamei, Zhou, Caiyun, Zhong, Kevin R, Smith, Stephen V, Teague, Ian M, Kennedy, Margaret G, Ménache
Publikováno v:
Research report (Health Effects Institute). (135)
Particulate matter (PM*) has been associated with a variety of adverse health effects, primarily involving the cardiovascular and respiratory systems. Researchers continue to investigate biologic mechanisms that may explain how exposure to PM exacerb
Publikováno v:
Neuroscience & Biobehavioral Reviews. 15:63-69
Mathematical models used to study deposition of inhaled toxicants require morphometric data to represent the tracheobronchial airways of laboratory animals. Because of the difficulty and cost of obtaining detailed measurements, morphometric models ar
Publikováno v:
Inhalation toxicology. 20(2)
Single-path whole-lung and lobar models of the lungs of 11 children between 3 mo and 21 yr of age were developed based on a combination of cast data and published information on distal airway dimensions. The cast data used to generate these models we