Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Margaret G. Eason"'
Publikováno v:
Biochemistry. 37:15720-15725
One mechanism of long-term agonist-promoted desensitization of alpha2AR function is downregulation of the cellular levels of the alpha subunit of the inhibitory G protein, Gi. In transfected CHO cells expressing the human alpha2AAR, a 40.1 +/- 3.3% d
Autor:
Dennis W. McGraw, Stephen B. Liggett, Stuart A. Green, Margaret G. Eason, Elizabeth T. Donnelly
Publikováno v:
Cellular Signalling. 10:197-204
Phosphorylation of the beta 2-adrenergic receptor (beta 2AR) is the initial event that underlies rapid agonist-promoted desensitisation. However, the role of phosphorylation in mediating long-term beta 2AR desensitisation is not known. To investigate
Autor:
Stephen B. Liggett, Margaret G. Eason
Publikováno v:
Journal of Biological Chemistry. 271:12826-12832
We have investigated potential Gi and Gs coupling domains within the intracellular regions of the alpha2AAR subtype using a series of nine chimeric mutations. The second intracellular loop (ICL2, amino acids 133-149) and the amino- and carboxyl-termi
Autor:
Lorena Cattaneo, Silvano G. Cella, Margaret G. Eason, Takahiko Fujikawa, Stella Campo, Eugenio E. Müller, Peter J. Sharp, Ian C. Dunn, R. Pansini, Monica G. Ferrini, Silvina Creus, Cynthia L. Bethea, Karen S.L Lam, Man Fong Lee, Donna L. Maney, Ricardo S. Calandra, Sau Ping Tam, Mariolina Luceri, Florence Demay, Andreas Kjaer, Karen K. Beattie, Eliana Herminia Pellizzari, Angelo Margutti, Cynthia M. Kuhn, Alberto Valentini, Jørgen Warberg, Susana B. Rulli, Alejandro F. De Nicola, Kesami Sakaguchi, Andrea A. Widmann, Franco Minuto, Claudia A. Grillo, Kunio Nakashima, Gopesh Srivastava, Antonio Torsello, Gerardo G. Piroli, Frederik H.E. Schagen, Ulrich Knigge, Selva B. Cigorraga, Maria Rosaria Ambrosio, Melanie Pecins-Thompson, Gérard Tramu, Jean-Rémi Pape, Marie-Lise Thieulant, Shu Sudo, Ezio Ghigo, Reynold Francis, Victoria Lux-Lantos, Philip J. Larsen, Peter W.F. Wilson, Ettore C. degli Uberti, Richard Talbot, Christophe Tiffoche, Helen Sang, Silvano Cella, Katsumi Doh-ura, Takeshi Ohkubo, Giorgio Trasforini, Minoru Tanaka
Publikováno v:
Neuroendocrinology. 63:I-IV
Autor:
Margaret G. Eason, Stephen B. Liggett
Publikováno v:
Journal of Biological Chemistry. 270:24753-24760
alpha2-Adrenergic receptors (alpha 2AR) functionally couple not only to Gi but also to Gs. We investigated the amino-terminal portion of the third intracellular loop of the human alpha 2AAR (alpha 2C10) for potential Gs coupling domains using site-di
Publikováno v:
Journal of Biological Chemistry. 270:4681-4688
During short term agonist exposure, the alpha 2A-adrenergic receptor (alpha 2AAR) undergoes rapid functional desensitization caused by phosphorylation of the receptor by the beta-adrenergic receptor kinase (beta ARK). This signal quenching is similar
Autor:
Stephen B. Liggett, Margaret G. Eason
Publikováno v:
Journal of Biological Chemistry. 267:25473-25479
We have recently shown that the alpha 2C10 adrenergic receptor (AR) undergoes short term agonist-promoted desensitization, mediated by phosphorylation of sites in the third intracellular loop. There is significant divergence in the third loop amino a
Publikováno v:
European journal of pharmacology. 437(1-2)
The alpha2A-adrenoceptor undergoes desensitization in response to protein kinase C activation. Using mutagenesis and recombinant expression we sought to determine the specific sites within the receptor which are phosphorylated by protein kinase C and
Autor:
Gerald W. Dorn, Margaret G. Eason, Cheryl T. Theiss, Elizabeth A. Jewell-Motz, Stephen B. Liggett, Mark A. Williams, Mei Liang
Publikováno v:
Molecular pharmacology. 54(1)
We have investigated the potential for protein kinase C (PKC) to phosphorylate and desensitize the alpha2A-adrenergic receptor (alpha2AAR). In whole-cell phosphorylation studies, recombinantly expressed human alpha2AAR displayed an increase in phosph
Publikováno v:
Neuroendocrinology. 63(6)
The purpose of the present study was to evaluate the opioid receptor subtype mediating opioid modulation of growth hormone (GH) secretion during ontogeny. The mu-agonist morphine and the kappa agonist U50,488 caused a stimulation and inhibition of GH