Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Margaret Frame"'
Autor:
Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Granzyme B is found in activated T cells and can be used as a marker of T cell activation. Here, the authors generate a fluorescent probe that can detect Granzyme B levels in tumours, and has the potential to be used as a biomarker of response to imm
Externí odkaz:
https://doaj.org/article/773a1c7cda434f51a8e1ac084abce313
Autor:
John C. Dawson, Alison Munro, Kenneth Macleod, Morwenna Muir, Paul Timpson, Robert J. Williams, Margaret Frame, Valerie G. Brunton, Neil O. Carragher
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1072-1090 (2022)
A more comprehensive understanding of how cells respond to drug intervention, the likely immediate signalling responses and how resistance may develop within different microenvironments will help inform treatment regimes. The nonreceptor tyrosine kin
Externí odkaz:
https://doaj.org/article/fab8f61f00ef4132b7b597f9dca6a022
Autor:
Timothy Johanssen, Laura McVeigh, Sara Erridge, Geoffrey Higgins, Joelle Straehla, Margaret Frame, Tero Aittokallio, Neil O. Carragher, Daniel Ebner
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Glioblastoma (GBM) remains a cancer of high unmet clinical need. Current standard of care for GBM, consisting of maximal surgical resection, followed by ionisation radiation (IR) plus concomitant and adjuvant temozolomide (TMZ), provides less than 15
Externí odkaz:
https://doaj.org/article/6cf6e85854b04711b730a64dda9229c5
Autor:
Juan Pablo Macagno, Jesica Diaz Vera, Yachuan Yu, Iain MacPherson, Emma Sandilands, Ruth Palmer, Jim C Norman, Margaret Frame, Marcos Vidal
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004262 (2014)
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downst
Externí odkaz:
https://doaj.org/article/5abc0a13ae3b4fa48e42b051edf906a3
Autor:
null John C Dawson, null Alison Munro, null Kenneth Macleod, null Morwenna Muir, null Paul Timpson, null Robert J Williams, null Margaret Frame, null Val G Brunton, null Neil O Carragher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b28e129bec16cb82dc627a59c6f2a01
https://doi.org/10.1002/1878-0261.13151/v2/response1
https://doi.org/10.1002/1878-0261.13151/v2/response1
Autor:
Zhen, Qiu, Rhodri S, Wilson, Yuewei, Liu, Alison R, Dun, Rebecca S, Saleeb, Dongsheng, Liu, Colin, Rickman, Margaret, Frame, Rory R, Duncan, Weiping, Lu
Publikováno v:
Scientific Reports
Super-resolution microscopy is transforming our understanding of biology but accessibility is limited by its technical complexity, high costs and the requirement for bespoke sample preparation. We present a novel, simple and multi-color super-resolut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fa3ed113d18de7b5089fd1ab95d0497
https://pubmed.ncbi.nlm.nih.gov/26822455
https://pubmed.ncbi.nlm.nih.gov/26822455
Autor:
Giulia, Villari, Asier, Jayo, Jennifer, Zanet, Briana, Fitch, Bryan, Serrels, Margaret, Frame, Brian M, Stramer, Benjamin T, Goult, Maddy, Parsons
Publikováno v:
Journal of Cell Science
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo. However, potential non-actin bundling roles for f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::261522cdcfc7430bba0875af51bd7bc2
https://pubmed.ncbi.nlm.nih.gov/26542021
https://pubmed.ncbi.nlm.nih.gov/26542021
Autor:
C. Margaret Frame, Burkhard Haefner
Publikováno v:
Biochemical Journal. 328:649-655
In chicken embryo fibroblasts, the binding of v-Src to PtdIns 3-kinase requires Src homology domains, SH3, SH2 and the SH1 or kinase domain, which induces the cytoskeletal disruption associated with fibroblast transformation. In the rat phaeochromocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf5aef525efaaa7fba8a11d558f59a0
https://doi.org/10.1042/bj3280649
https://doi.org/10.1042/bj3280649
Autor:
Stavrou, Maria, Selvaraj, Bhuvaneish, Bolado, Alfonso, James, Longden, Neil, Carragher, Margaret, Frame, Hardingham, Giles, Chandran, Siddharthan
Publikováno v:
Journal of Neurology, Neurosurgery, & Psychiatry (JNNP); 2022, Vol. 93 Issue: 6 pA146-A146, 1p