Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Margaret Favata"'
Autor:
Yaoyu Chen, Margaret Favata, Michelle Pusey, Jun Li, Yvonne Lo, Min Ye, Richard Wynn, Xiaozhao Wang, Wenqing Yao, Yingnan Chen
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-9 (2020)
Abstract Background The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest–specific protein 6 (GAS6)–induced MER phosphorylation is often unstable and difficult to detect without pervanadate pretrea
Externí odkaz:
https://doaj.org/article/871c0005c54e4b25b13d6257133f0ae7
Autor:
Jonathan Rios-Doria, Margaret Favata, Kerri Lasky, Patricia Feldman, Yvonne Lo, Gengjie Yang, Christina Stevens, Xiaoming Wen, Sarita Sehra, Kamna Katiyar, Ke Liu, Richard Wynn, Jennifer J. Harris, Min Ye, Susan Spitz, Xiaozhao Wang, Chunhong He, Yun-Long Li, Wenqing Yao, Maryanne Covington, Peggy Scherle, Holly Koblish
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, which play important roles in tumor growth, survival, cell adhesion, as well as innate immunity, phagocytosis, and immune-suppressive activity. Therefore, targeting both AX
Externí odkaz:
https://doaj.org/article/8d1cee9d42734905aea555ac4d51cd11
Autor:
Jun Li, Margaret Favata, Jennifer A. Kelley, Eian Caulder, Beth Thomas, Xiaoming Wen, Richard B. Sparks, Ari Arvanitis, James D. Rogers, Andrew P. Combs, Kris Vaddi, Kimberly A. Solomon, Peggy A. Scherle, Robert Newton, Jordan S. Fridman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 28-38 (2010)
Cytokines in the bone marrow of multiple myeloma patients activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways in tumor cells and promote tumor growth, survival, and drug resistance. INCB16562 was dev
Externí odkaz:
https://doaj.org/article/8ff70b38f3cd4dcba837d81f78e72017
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Supplemental Tables 1 & 2 Supplemental Figure Legends Supplemental Figures 1 - 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9cd1caeb5c5e06cfd8b05f86b576b1
https://doi.org/10.1158/1078-0432.22475952
https://doi.org/10.1158/1078-0432.22475952
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Purpose:Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67622e0fbfefceb9ea9cf87738b999fe
https://doi.org/10.1158/1078-0432.c.6529230.v1
https://doi.org/10.1158/1078-0432.c.6529230.v1
Autor:
Angela Abdollahi, Margaret Favata, Darlise DiMatteo, Sean Schuette, Erika Boarder, Mark Rupar, Ricardo Macarron, Aidan Gilmartin, Hui Wang, Alejandro Amador-Arjona
Publikováno v:
Cancer Research. 83:412-412
Background: Lung cancer is one of the most common tumors, accounting for approximately 1.8 million deaths worldwide in 2020. KRAS is a frequently mutated oncogene, with mutations reported in roughly 20-25% of non-small cell lung cancer cases. Specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c845fa430a600accfbcaa385e09d5114
https://doi.org/10.1158/1538-7445.am2023-412
https://doi.org/10.1158/1538-7445.am2023-412
Autor:
Margaret Favata, Michael Weber, Angela Abdollahi, Valerie Dostalik Roman, Matt Farren, Aidan Gilmartin, Sunkyu Kim, Susan Wee, Jonathan Rios-Doria
Publikováno v:
Cancer Research. 83:430-430
KRAS is one of the most frequently mutated oncogenes. Clinical studies with recently developed covalent KRASG12C inhibitors have shown promising anticancer activity in patients with KRASG12C tumors (substitution of glycine to cysteine at amino acid 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34c8afdce258ef4b93b09324bc4b8b50
https://doi.org/10.1158/1538-7445.am2023-430
https://doi.org/10.1158/1538-7445.am2023-430
Autor:
Reid Huber, Maryanne Covington, Xin He, Paul Waeltz, Valerie Dostalik, Yanlong Li, Nina Zolotarjova, Chu-Biao Xue, Matthew C. Stubbs, Jun Li, Huiqing Liu, Peggy Scherle, Timothy Burn, Sharon Diamond, Thomas Maduskuie, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Christine Gardiner, Xuesong Mike Liu, Robert Collins, Nikoo Falahatpisheh, Andrew P. Combs, Phillip Liu, Margaret Favata, Gregory Hollis, Richard Wynn, Swamy Yeleswaram, Bruce Ruggeri, Alla Volgina, Ravi Kumar Jalluri, Pramod Thekkat, Darlise DiMatteo, Patricia Feldman, Mark Rupar, Xiaoming Wen
Publikováno v:
Clinical Cancer Research. 25:300-311
Purpose: Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0f9e6b013bb2a593a4e013aa8feee1
https://doi.org/10.1158/1078-0432.ccr-18-0098
https://doi.org/10.1158/1078-0432.ccr-18-0098
Autor:
Sharon Diamond, Taisheng Huang, Karen Gallagher, Jun Li, Brittany Fay, Monika Scuron, Michael Peel, Robert C. Newton, Niu Shin, Ashish Juvekar, Peggy Scherle, Xin He, Julian Oliver, Robert Collins, Chu-Biao Xue, Krista Burke, Yan Zhang, Paul Smith, Wenqing Yao, Maryanne Covington, Margaret Favata, Sarala Sarah
Publikováno v:
European Journal of Pharmacology. 885:173505
Pharmacological modulation of the Janus kinase (JAK) family has achieved clinically meaningful therapeutic outcomes for the treatment of inflammatory and hematopoietic diseases. Several JAK1 selective compounds are being investigated clinically to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b303ded56282c591cd24d94685b79bfe
https://doi.org/10.1016/j.ejphar.2020.173505
https://doi.org/10.1016/j.ejphar.2020.173505
Autor:
Niu, Shin, Yun-Long, Li, Song, Mei, Kathy He, Wang, Leslie, Hall, Kamna, Katiyar, Qian, Wang, Gengjie, Yang, Beth, Rumberger, Lynn, Leffet, Xin, He, Mark, Rupar, Kevin, Bowman, Margaret, Favata, Jun, Li, Mike, Liu, Yanlong, Li, Maryanne, Covington, Holly, Koblish, Maxim, Soloviev, Dana, Shuey, Timothy, Burn, Sharon, Diamond, Jordan, Fridman, Andrew, Combs, Wenqing, Yao, Swamy, Yeleswaram, Gregory, Hollis, Kris, Vaddi, Reid, Huber, Robert, Newton, Peggy, Scherle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 364(1)
Phosphatidylinositol 3-kinase delta (PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::baeaea6f34f538a85fee066a6746ba98
https://pubmed.ncbi.nlm.nih.gov/29127109
https://pubmed.ncbi.nlm.nih.gov/29127109