Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Margaret Esapa"'
Autor:
O. Kan, S. Iqball, Robert E MacLaren, Robin R. Ali, Kamaljit S. Balaggan, S. E. Barker, Margaret Esapa, Rachael A. Pearson, James W B Bainbridge, Katie Binley, Yanai Duran, Stuart Naylor, Andrew Smith
Publikováno v:
Gene Therapy. 13:1153-1165
We evaluated the efficacy of equine infectious anaemia virus (EIAV)-based lentiviral vectors encoding endostatin (EIAV.endostatin) or angiostatin (EIAV.angiostatin) in inhibiting angiogenesis and vascular hyperpermeability in the laser-induced model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b654ccbfa325d4fa6732b1cdfdefdb
https://doi.org/10.1038/sj.gt.3302769
https://doi.org/10.1038/sj.gt.3302769
Autor:
Susan M. Kingsman, Julia A. Sutton, Margaret Esapa, Toby Price, Dilair F. Baban, Jason Slingsby, Alan J. Kingsman, Andrew Slade
Publikováno v:
Human Gene Therapy. 11:1439-1451
A number of stable producer cell lines for high-titer Mo-MuLV vectors have been constructed. Development has previously centered on increasing end-point titers by producing maximal levels of Mo-MuLV Gag/Pol, envelope glycoproteins, and retroviral RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6027db4c95f28d27bdbc822cb30b00f8
https://doi.org/10.1089/10430340050057512
https://doi.org/10.1089/10430340050057512
Autor:
James Miskin, Georgina Ferrige, Michelle Kelleher, Katie Binley, Vladimir Bantseev, Paul E. Miller, T Michael Nork, Diana Angell-Manning, Stuart Naylor, Peter Widdowson, Kyriacos A. Mitrophanous, Jackie de Belin, Julie Loader, Marie Carlucci, Margaret Esapa, Scott Ellis, Daniel Chipchase
Publikováno v:
Human gene therapy. 23(9)
RetinoStat(®) is an equine infectious anemia virus-based lentiviral gene therapy vector that expresses the angiostatic proteins endostatin and angiostatin that is delivered via a subretinal injection for the treatment of the wet form of age-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0134cf5dfad7d5d56cfddfaf2ee4ad4
https://pubmed.ncbi.nlm.nih.gov/22716662
https://pubmed.ncbi.nlm.nih.gov/22716662
Autor:
James W B Bainbridge, Stuart Naylor, S. Iqball, Z. Askham, Margaret Esapa, Kamaljit S. Balaggan, M. Tschernutter, Robin R. Ali, O. Kan, Katie Binley
Publikováno v:
The journal of gene medicine. 8(3)
Background We have developed minimal non-primate lentiviral vectors based on the equine infectious anaemia virus (EIAV). We evaluated the in vivo expression profiles of these vectors delivered regionally to ocular tissues to define their potential ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a450d2199ad7e70454c90fa54def1c
https://pubmed.ncbi.nlm.nih.gov/16299834
https://pubmed.ncbi.nlm.nih.gov/16299834
Autor:
Alan J. Kingsman, Hayley Spearman, Jason Slingsby, Margaret Esapa, Stuart Naylor, Andrew Slade, L Griffiths, Dilair Baban, Susan M. Kingsman, Mark Uden, Toby Price, O. Kan, S. Iqball
Publikováno v:
Cancer gene therapy. 8(7)
Human cytochrome P450 2B6 (CYP2B6) metabolizes the prodrug cyclophosphamide (CPA) to produce phosphoramide mustard that cross-links DNA leading to cell death. We have constructed a novel retroviral vector encoding CYP2B6 (designated “MetXia-P450”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcad8b8549ed7d36679e4d15af01ca31
https://pubmed.ncbi.nlm.nih.gov/11498768
https://pubmed.ncbi.nlm.nih.gov/11498768
Autor:
Naoyasu Umeda, S. Iqball, Katie Binley, Stuart Naylor, Michiko Kachi, Shu Kachi, Hideo Akiyama, Raquel Lima e Silva, Peter A. Campochiaro, Wei-Hong Xiao, Margaret Esapa
Publikováno v:
Molecular Therapy. 11:S39
EIAV vectors have been shown to have substantial potential for long-term expression of transgenes, but the optimal promoter for various applications has not been worked out. In this study, we compared EIAV-mediated ocular gene transfer using a CMV pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e8f78ca7d4565ebfb058076e65e84e9
https://doi.org/10.1016/j.ymthe.2005.06.102
https://doi.org/10.1016/j.ymthe.2005.06.102