Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Margaret E. Gruen"'
Autor:
Chin-Chieh Yang, Pew-Thian Yap, Ye Wu, Natalia Zidan, Gilad Fefer, Nathan C. Nelson, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Presbycusis, or age-related hearing loss, affects both elderly humans and dogs, significantly impairing their social interactions and cognition. In humans, presbycusis involves changes in peripheral and central auditory systems, with central
Externí odkaz:
https://doaj.org/article/c4ac4bc866d845a1a29df56492829e7c
Autor:
Katherine E. Simon, Katharine Russell, Alejandra Mondino, Chin-Chieh Yang, Beth C. Case, Zachary Anderson, Christine Whitley, Emily Griffith, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Age-related decline in mobility and cognition are associated with cellular senescence and NAD + depletion in dogs and people. A combination of a novel NAD + precursor and senolytic, LY-D6/2, was examined in this randomized controlled trial.
Externí odkaz:
https://doaj.org/article/fe8940694bdf4905b3f233e0ac4ebea5
Autor:
Rachel M. P. Caddiell, Philip White, B. Duncan X. Lascelles, Kenneth Royal, Kimberly Ange-van Heugten, Margaret E. Gruen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Dog breed stereotypes are frequently used to inform people’s expectations about canine behavior, despite evidence that breed is largely uninformative in predicting individual dog behavior. Further, these beliefs differ among populations. H
Externí odkaz:
https://doaj.org/article/30acfbd397434246bdbeaa688a80605a
Autor:
Rachel M. P. Caddiell, Philip White, B. Duncan X. Lascelles, Kenneth Royal, Kimberly Ange-van Heugten, Margaret E. Gruen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Over 95% of veterinarians report believing that dog breeds differ in pain sensitivity. Ratings made by veterinarians differ from those of the general public, suggesting these beliefs may be learned during veterinary training or clinical expe
Externí odkaz:
https://doaj.org/article/95cb54301ad04213984d2e7a5102845b
Publikováno v:
Animals, Vol 14, Iss 4, p 545 (2024)
Imepitoin is a low-affinity partial agonist for benzodiazepine binding sites of gamma-aminobutyric acid receptors with anxiolytic effects. It has been shown to reduce anxiety during noise-related events in dogs when given at 30 mg/kg PO BID, although
Externí odkaz:
https://doaj.org/article/e8dbeb7504f34f5387fa2546d3346a89
Autor:
Ginger B. Templeton, Gilad Fefer, Beth C. Case, Jeff Roach, M. Andrea Azcarate-Peril, Margaret E. Gruen, Benjamin J. Callahan, Natasha J. Olby
Publikováno v:
Animals, Vol 13, Iss 24, p 3846 (2023)
Aged companion dogs have a high prevalence of periodontal disease and canine cognitive dysfunction syndrome (CCDS) and the two disorders are correlated. Similarly, periodontal disease and Alzheimer’s Disease are correlated in people. However, littl
Externí odkaz:
https://doaj.org/article/12d4870445654407a65ae0dd879b8d89
Autor:
Rachel M. P. Caddiell, Rachael M. Cunningham, Philip A. White, B. Duncan X. Lascelles, Margaret E. Gruen
Publikováno v:
Frontiers in Pain Research, Vol 4 (2023)
BackgroundVeterinarians hold distinct breed-specific pain sensitivity beliefs that differ from the general public but are highly consistent with one another. This is remarkable as there is no current scientific evidence for biological differences in
Externí odkaz:
https://doaj.org/article/f04a6b1e2e384135b0d94fbe8197b87c
Autor:
Alejandra Mondino, Michael Khan, Beth Case, Gilad Fefer, Wojciech K. Panek, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionIn humans, gait speed is a crucial component in geriatric evaluation since decreasing speed can be a harbinger of cognitive decline and dementia. Aging companion dogs can suffer from age-related mobility impairment, cognitive decline and
Externí odkaz:
https://doaj.org/article/a269767f50b24757a41ac2fc1b640112
Autor:
Gilad Fefer, Michael Z. Khan, Wojciech K. Panek, Beth Case, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 5, Pp 1708-1718 (2022)
Abstract Background Elderly people with presbycusis are at higher risk for dementia and depression than the general population. There is no information regarding consequences of presbycusis in dogs. Objective Evaluate the relationship between cogniti
Externí odkaz:
https://doaj.org/article/b0d014c49fcc4d1a864a6c8aa30c16a2
Autor:
Alejandra Mondino, Magaly Catanzariti, Diego Martin Mateos, Michael Khan, Claire Ludwig, Anna Kis, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionSleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer's disease) occurs during sleep. Some electroencephalographic characteristics of slee
Externí odkaz:
https://doaj.org/article/c1d1c6a7838641b7b7ba4f6e5ea9476a