Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Margaret E Maes"'
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184434 (2017)
The pro-apoptotic BCL2 gene family member, BAX, plays a pivotal role in the intrinsic apoptotic pathway. Under cellular stress, BAX recruitment to the mitochondria occurs when activated BAX forms dimers, then oligomers, to initiate mitochondria outer
Externí odkaz:
https://doaj.org/article/6aa7dcebc00745d4bda6a5f8d4413e82
Autor:
Joel A Dietz, Margaret E Maes, Shuang Huang, Brian S Yandell, Cassandra L Schlamp, Angela D Montgomery, R Rand Allingham, Michael A Hauser, Robert W Nickells
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93564 (2014)
The Rgcs1 quantitative trait locus, on mouse chromosome 5, influences susceptibility of retinal ganglion cells to acute damage of the optic nerve. Normally resistant mice (DBA/2J) congenic for the susceptible allele from BALB/cByJ mice exhibit suscep
Externí odkaz:
https://doaj.org/article/9f5b02ad14dc4ceba5cfe49d6a15feba
Autor:
Margaret E. Maes, Ryan J. Donahue, Cassandra L. Schlamp, Olivia J. Marola, Richard T. Libby, Robert W. Nickells
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the mitochondrial outer membrane (MOM) and then pe
Externí odkaz:
https://doaj.org/article/7657e4fe09f54146a892dfbcaf469f51
Autor:
Margaret E. Maes, Gloria Colombo, Florianne E. Schoot Uiterkamp, Felix Sternberg, Alessandro Venturino, Elena E. Pohl, Sandra Siegert
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107780- (2023)
Summary: Mitochondrial networks remodel their connectivity, content, and subcellular localization to support optimized energy production in conditions of increased environmental or cellular stress. Microglia rely on mitochondria to respond to these s
Externí odkaz:
https://doaj.org/article/0ff2e77f70154f09837e9ef0855fee45
Autor:
Margaret E. Maes, Gabriele M. Wögenstein, Gloria Colombo, Raquel Casado-Polanco, Sandra Siegert
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 210-224 (2021)
Adeno-associated viruses (AAVs) are widely used to deliver genetic material in vivo to distinct cell types such as neurons or glial cells, allowing for targeted manipulation. Transduction of microglia is mostly excluded from this strategy, likely due
Externí odkaz:
https://doaj.org/article/8e7352fa5ae14417bfd0e187c5d96c5c
Autor:
Nicole A. Muench, Sonia Patel, Margaret E. Maes, Ryan J. Donahue, Akihiro Ikeda, Robert W. Nickells
Publikováno v:
Cells, Vol 10, Iss 7, p 1593 (2021)
The important roles of mitochondrial function and dysfunction in the process of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a highly vulnerable neuronal cell type in the central nervous system with respect to
Externí odkaz:
https://doaj.org/article/881a629da11c4c40a617383655be56e0
Autor:
Raquel Casado-Polanco, Gloria Colombo, Gabriele M. Wögenstein, Margaret E. Maes, Sandra Siegert
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 210-224 (2021)
Molecular Therapy-Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 210-224 (2021)
Molecular Therapy-Methods & Clinical Development
Adeno-associated viruses (AAVs) are widely used to deliver genetic material in vivo to distinct cell types such as neurons or glial cells, allowing for targeted manipulation. Transduction of microglia is mostly excluded from this strategy, likely due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4f2b5b7c11736b8d15170684e38f58
http://europepmc.org/articles/PMC8516996
http://europepmc.org/articles/PMC8516996
Environmental cues influence microglial interaction with their neuronal landscape, often causing changes in microglial functional identity. This process demands rapid energy production, which is supported by an optimized mitochondrial network. Whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddea7a29a969b62c0f99d855e904be9a
https://doi.org/10.1101/2022.08.22.504738
https://doi.org/10.1101/2022.08.22.504738
Publikováno v:
Mol Neurobiol
BACKGROUND: Removal of the Bax gene from mice completely protects the somas of retinal ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes BAX a promising therapeutic target to prevent neurodegeneration. In this study, Bax(+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d133e8ba52c26921ab81f12b7b3e4d5
https://doi.org/10.1007/s12035-019-01783-7
https://doi.org/10.1007/s12035-019-01783-7
Publikováno v:
Apoptosis
Recent advancements in live cell imaging technologies have identified the phenomenon of intracellular propagation of late apoptotic events, such as cytochrome c release and caspase activation. The mechanism, prevalence, and speed of apoptosis propaga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4baea0d838ff120abfa481b2d06190b
https://pubmed.ncbi.nlm.nih.gov/33426618
https://pubmed.ncbi.nlm.nih.gov/33426618