Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Margaret E Gruen"'
Autor:
Chin-Chieh Yang, Pew-Thian Yap, Ye Wu, Natalia Zidan, Gilad Fefer, Nathan C. Nelson, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Presbycusis, or age-related hearing loss, affects both elderly humans and dogs, significantly impairing their social interactions and cognition. In humans, presbycusis involves changes in peripheral and central auditory systems, with central
Externí odkaz:
https://doaj.org/article/c4ac4bc866d845a1a29df56492829e7c
Autor:
Katherine E. Simon, Katharine Russell, Alejandra Mondino, Chin-Chieh Yang, Beth C. Case, Zachary Anderson, Christine Whitley, Emily Griffith, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Age-related decline in mobility and cognition are associated with cellular senescence and NAD + depletion in dogs and people. A combination of a novel NAD + precursor and senolytic, LY-D6/2, was examined in this randomized controlled trial.
Externí odkaz:
https://doaj.org/article/fe8940694bdf4905b3f233e0ac4ebea5
Autor:
Katharine J. Russell, Alejandra Mondino, Gilad Fefer, Emily Griffith, Korinn Saker, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionFrailty is a well-defined clinical syndrome in humans caused by accumulation of impairments which result in loss of reserve capacity and increased vulnerability to disability, dependence, and death. Dogs are of particular interest in stud
Externí odkaz:
https://doaj.org/article/789deb5fb41d4673a1a472704422bbc3
Autor:
Rachel M. P. Caddiell, Philip White, B. Duncan X. Lascelles, Kenneth Royal, Kimberly Ange-van Heugten, Margaret E. Gruen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Dog breed stereotypes are frequently used to inform people’s expectations about canine behavior, despite evidence that breed is largely uninformative in predicting individual dog behavior. Further, these beliefs differ among populations. H
Externí odkaz:
https://doaj.org/article/30acfbd397434246bdbeaa688a80605a
Autor:
Rachel M. P. Caddiell, Philip White, B. Duncan X. Lascelles, Kenneth Royal, Kimberly Ange-van Heugten, Margaret E. Gruen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Over 95% of veterinarians report believing that dog breeds differ in pain sensitivity. Ratings made by veterinarians differ from those of the general public, suggesting these beliefs may be learned during veterinary training or clinical expe
Externí odkaz:
https://doaj.org/article/95cb54301ad04213984d2e7a5102845b
Autor:
Alejandra Mondino, Chin-Chieh Yang, Katherine E Simon, Gilad Fefer, James Robertson, Margaret E Gruen, Natasha J Olby
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0301181 (2024)
Advancements in veterinary medicine have resulted in increased life spans for dogs, necessitating a better understanding of quality of life for older dogs. This study aimed to evaluate quality of life (QoL) progression and its potential association w
Externí odkaz:
https://doaj.org/article/6963d076ea6149b48a2cc6c4796816f9
Publikováno v:
Animals, Vol 14, Iss 4, p 545 (2024)
Imepitoin is a low-affinity partial agonist for benzodiazepine binding sites of gamma-aminobutyric acid receptors with anxiolytic effects. It has been shown to reduce anxiety during noise-related events in dogs when given at 30 mg/kg PO BID, although
Externí odkaz:
https://doaj.org/article/e8dbeb7504f34f5387fa2546d3346a89
Autor:
Gilad Fefer, Michael Z. Khan, Wojciech K. Panek, Beth Case, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 5, Pp 1708-1718 (2022)
Abstract Background Elderly people with presbycusis are at higher risk for dementia and depression than the general population. There is no information regarding consequences of presbycusis in dogs. Objective Evaluate the relationship between cogniti
Externí odkaz:
https://doaj.org/article/b0d014c49fcc4d1a864a6c8aa30c16a2
Autor:
Rachel M. P. Caddiell, Rachael M. Cunningham, Philip A. White, B. Duncan X. Lascelles, Margaret E. Gruen
Publikováno v:
Frontiers in Pain Research, Vol 4 (2023)
BackgroundVeterinarians hold distinct breed-specific pain sensitivity beliefs that differ from the general public but are highly consistent with one another. This is remarkable as there is no current scientific evidence for biological differences in
Externí odkaz:
https://doaj.org/article/f04a6b1e2e384135b0d94fbe8197b87c
Autor:
Alejandra Mondino, Michael Khan, Beth Case, Gilad Fefer, Wojciech K. Panek, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionIn humans, gait speed is a crucial component in geriatric evaluation since decreasing speed can be a harbinger of cognitive decline and dementia. Aging companion dogs can suffer from age-related mobility impairment, cognitive decline and
Externí odkaz:
https://doaj.org/article/a269767f50b24757a41ac2fc1b640112