Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Margaret E Flanagan"'
Autor:
Rachel Keszycki, Pouya Jamshidi, Allegra Kawles, Grace Minogue, Margaret E Flanagan, Colleen R Zaccard, M Marsel Mesulam, Tamar Gefen, Changiz Geula
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 7, Pp 1498-1500 (2022)
Externí odkaz:
https://doaj.org/article/c1ae30abfcba4f11a82c0c3783cf02fc
Autor:
Preethy S. Sridharan, Yeojung Koh, Emiko Miller, Di Hu, Suwarna Chakraborty, Sunil Jamuna Tripathi, Teresa R. Kee, Kalyani Chaubey, Edwin Vázquez-Rosa, Sarah Barker, Hui Liu, Rose A. León-Alvarado, Kathryn Franke, Coral J. Cintrón-Pérez, Matasha Dhar, Min-Kyoo Shin, Margaret E. Flanagan, Rudolph J. Castellani, Tamar Gefen, Marina Bykova, Lijun Dou, Feixiong Cheng, Brigid M. Wilson, Hisashi Fujioka, David E. Kang, Jung-A.A. Woo, Bindu D. Paul, Xin Qi, Andrew A. Pieper
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101715- (2024)
Summary: Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers chronic neurodeg
Externí odkaz:
https://doaj.org/article/78517b6c384645a8be41713376606e5d
Autor:
Morgan Mekale Smith, Elizabeth Ochoa, Savannah Barannikov, Mallory Keating, Mohamad Habes, Margaret E. Flanagan, Sudha Seshadri, Kevin F. Bieniek
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103246- (2024)
Summary: Despite numerous neuropathological criteria for the evaluation of microscopic tissue slides, there are no systemic standards for sectioning postmortem human brain tissue. Here, we present a protocol for postmortem brain hybrid structured-lig
Externí odkaz:
https://doaj.org/article/80e35c9343934e4f8894c4661110771e
Autor:
Allegra Kawles, Rachel Keszycki, Grace Minogue, Antonia Zouridakis, Ivan Ayala, Nathan Gill, Alyssa Macomber, Vivienne Lubbat, Christina Coventry, Emily Rogalski, Sandra Weintraub, Qinwen Mao, Margaret E. Flanagan, Hui Zhang, Rudolph Castellani, Eileen H. Bigio, M.-Marsel Mesulam, Changiz Geula, Tamar Gefen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Pick’s disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterized by intraneuronal 3R-tau inclusions. PiD can underly various dementia syndromes, including primary progressive aphasia (PP
Externí odkaz:
https://doaj.org/article/f8eb9bfb83f045928c1b1d9fea4fa01c
Autor:
Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E. Flanagan, Rudolph Castellani, Eileen H. Bigio, M. Marsel Mesulam, Changiz Geula, Tamar Gefen
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-10 (2023)
Abstract The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer’s type due to Alzheimer’s disease (DAT-AD), but less is known about the
Externí odkaz:
https://doaj.org/article/c3711ddea19a4f54b2c1c8e2f3088908
Autor:
Daniel R. Wong, Ziqi Tang, Nicholas C. Mew, Sakshi Das, Justin Athey, Kirsty E. McAleese, Julia K. Kofler, Margaret E. Flanagan, Ewa Borys, Charles L. White, Atul J. Butte, Brittany N. Dugger, Michael J. Keiser
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Pathologists can label pathologies differently, making it challenging to yield consistent assessments in the absence of one ground truth. To address this problem, we present a deep learning (DL) approach that draws on a cohort of experts, we
Externí odkaz:
https://doaj.org/article/e7fb3386bbae4059a6d4c1c8990efffb
Autor:
Rudolph J. Castellani, Elisheva D. Shanes, Matthew McCord, Nicholas J. Reish, Margaret E. Flanagan, M-Marsel Mesulam, Pouya Jamshidi
Publikováno v:
Journal of Alzheimer's Disease. 93:803-813
Host responses to anti-amyloid-β (Aβ) antibody therapy are evident in neuroimaging changes and clinical symptoms in a subset of clinical trial subjects receiving such therapy. The pathological basis for the imaging changes and clinical symptoms is
Autor:
Jaclyn Lilek, Kaouther Ajroud, Alexander Z. Feldman, Sesha Krishnamachari, Shadi Ghourchian, Tamar Gefen, Callen L. Spencer, Allegra Kawles, Qinwen Mao, Jessica F. Tranovich, Clifford R. Jack, M-Marsel Mesulam, R. Ross Reichard, Hui Zhang, Melissa E. Murray, David Knopman, Dennis W. Dickson, Ronald C. Petersen, Benjamin Smith, Karen H. Ashe, Michelle M. Mielke, Kathryn M. Nelson, Margaret E. Flanagan
Publikováno v:
Journal of Alzheimer's Disease. 92:241-260
Background: Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer’s disease (AD). However, pathological tau accumulation and relationships to synaptic changes remain unclear. Objective: To address this
Autor:
Sara Rose Dunlop, Ivan Ayala, Callen Spencer, Margaret E Flanagan, Marek-Marsel Mesulam, Tamar Gefen, Changiz Geula
Publikováno v:
Journal of neuropathology and experimental neurology. 81(11)
Basal forebrain cholinergic neurons (BFCN) display accumulation of neurofibrillary tangles and degeneration in Alzheimer disease and are targets of therapeutic intervention. This study determined vulnerability of BFCN to accumulation of TDP-43 in pri
Autor:
Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Jean-Paul Vonsattel, Andy F Teich, Marla Gearing, Jonathan Glass, Juan C Troncoso, Matthew P Frosch, Bradley T Hyman, Melissa E Murray, Johannes Attems, Margaret E Flanagan, Qinwen Mao, M-Marsel Mesulam, Sandra Weintraub, Randy L Woltjer, Thao Pham, Julia Kofler, Julie A Schneider, Lei Yu, Dushyant P Purohit, Vahram Haroutunian, Patrick R Hof, Sam Gandy, Mary Sano, Thomas G Beach, Wayne Poon, Claudia H Kawas, María M Corrada, Robert A Rissman, Jeff Metcalf, Sara Shuldberg, Bahar Salehi, Peter T Nelson, John Q Trojanowski, Edward B Lee, David A Wolk, Corey T McMillan, C Dirk Keene, Caitlin S Latimer, Thomas J Montine, Gabor G Kovacs, Mirjam I Lutz, Peter Fischer, Richard J Perrin, Nigel J Cairns, Ann C McKee, John F Crary
Publikováno v:
Journal of neuropathology and experimental neurology. 81(10)
Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild head impacts characterized by perivascular hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs) and neurites in the depths of the neocortical sulci. In