Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Margaret E Brousseau"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)
Lowering low‐density lipoprotein cholesterol (LDL‐C) is a cornerstone of reducing risk for atherosclerotic cardiovascular disease. Despite the approval of nonstatin therapies for LDL‐C lowering over the past 2 decades, these medications are und
Externí odkaz:
https://doaj.org/article/835ec1596c954dc9a85b1b1de043360b
Autor:
Margaret R. Diffenderfer, Margaret E. Brousseau, John S. Millar, P.Hugh R. Barrett, Chorthip Nartsupha, Peter M. Schaefer, Megan L. Wolfe, Gregory G. Dolnikowski, Daniel J. Rader, Ernst J. Schaefer
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1190-1199 (2012)
Cholesteryl ester transfer protein (CETP) facilitates the transfer of HDL cholesteryl ester to triglyceride-rich lipoproteins (TRL). This study aimed to determine the effects of CETP inhibition with torcetrapib on TRL composition and apoB-48 metaboli
Externí odkaz:
https://doaj.org/article/fa9c3f7efd514b1fb91b9148d019c5da
Autor:
Arnaud Osmont, Walter Carbone, Vanessa Orsini, Florian Nigsch, Jonathan J. Turner, Christel Genoud, Shola M Richards, Laura Bollepalli, Enrica Saponara, Svenja Ley, Zhong-Yi Wang, Giovanni d'Ario, Alexandra Aebi, Meztli L Matadamas Guzmán, Philipp Tropberger, Stefano Annunziato, Chandrassegar Saravanan, Benoit Fischer, Guglielmo Roma, Tewis Bouwmeester, Michael Obrecht, Jan S. Tchorz, Virginie Brun, Heinz Ruffner, Nicolau Beckmann, Carlos A. Penno, Margaret E. Brousseau, Peter O'Donnell, Alexandra Graff Meyer, Iwona Ksiazek, Luigi Terraciano
Background & AimsThe Rspo-Lgr4/5-Znrf3/Rnf43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impact on nonalcoholic fatty liver disease (NAFLD) remains unclear. We studied whether liver-specific loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28cc1cd150989852141c4658c7ee558
https://doi.org/10.1101/2021.11.22.469602
https://doi.org/10.1101/2021.11.22.469602
Autor:
Margaret E Brousseau, Kevin B Clairmont, Glen Spraggon, Alec N Flyer, Andrei A Golosov, Philipp Grosche, Jérôme André, Shari Caplan, Guanjing Chen, Li Fan, Raphael Gattlen, Alexander Koch, Ian Lewis, Jingzhou Li, Eugene Liu, Danuta Lubicka, Andreas Marzinzik, Katsumasa Nakajima, David Nettleton, Johannes Ottl, Meihui Pan, Tajesh Patel, Stephanie Pickett, Jennifer Poirier, Patrick C Reid, Xavier Pelle, Vanitha Subramanian, Victoria Vera, Mei Xu, Lihua Yang, Qing Yang, jinghua yu, Guoming Zhu, Lauren G Monovich
Publikováno v:
Circulation. 144
Elevated LDL-C is a major risk factor for atherosclerotic cardiovascular disease, the leading cause of death worldwide. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has pronounced effects on LDL-C levels via its modulation of hepatic LDL rec
Autor:
Gina M. Peloso, Serkalem Demissie, Dorothea Collins, Daniel B. Mirel, Stacey B. Gabriel, L. Adrienne Cupples, Sander J. Robins, Ernst J. Schaefer, Margaret E. Brousseau
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 12, Pp 3524-3532 (2010)
A low level of HDL-C is the most common plasma lipid abnormality observed in men with established coronary heart disease (CHD). To identify allelic variants associated with susceptibility to low HDL-C and CHD, we examined 60 candidate genes with key
Externí odkaz:
https://doaj.org/article/e9f4c00a7c0c48058d81ecb6b355a21c
Autor:
Margaret E. Brousseau, John S. Millar, Margaret R. Diffenderfer, Chorthip Nartsupha, Bela F. Asztalos, Megan L. Wolfe, James P. Mancuso, Andres G. Digenio, Daniel J. Rader, Ernst J. Schaefer
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 7, Pp 1456-1462 (2009)
This study was designed to establish the mechanism responsible for the increased apolipoprotein (apo) A-II levels caused by the cholesteryl ester transfer protein inhibitor torcetrapib. Nineteen subjects with low HDL cholesterol (
Externí odkaz:
https://doaj.org/article/136923cae7b94b1d8203c6d7c1c787a6
Autor:
John S. Millar, Margaret E. Brousseau, Margaret R. Diffenderfer, P. Hugh R. Barrett, Francine K. Welty, Jeffrey S. Cohn, Aisha Wilson, Megan L. Wolfe, Chorthip Nartsupha, Peter M. Schaefer, Andres G. Digenio, James P. Mancuso, Gregory G. Dolnikowski, Ernst J. Schaefer, Daniel J. Rader
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 3, Pp 543-549 (2008)
Cholesteryl ester transfer protein (CETP) inhibition leads to changes in lipoprotein metabolism. We studied the effect of the CETP inhibitor torcetrapib on VLDL apolipoprotein E (apoE) metabolism. Subjects, pretreated with atorvastatin (n = 9) or unt
Externí odkaz:
https://doaj.org/article/a04a79f8a7cf41729eb1fdd834ca518e
Autor:
Margaret E. Brousseau, Allison L. Goldkamp, Dorothea Collins, Serkalem Demissie, Allison C. Connolly, L. Adrienne Cupples, Jose M. Ordovas, Hanna E. Bloomfield, Sander J. Robins, Ernst J. Schaefer
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 10, Pp 1885-1891 (2004)
Our goal was to further define the role of LPL gene polymorphisms in coronary heart disease (CHD) risk. We determined the frequencies of three LPL polymorphisms (D9N, N291S, and S447X) in 899 men from the Veterans Affairs HDL Intervention Trial (VA-H
Externí odkaz:
https://doaj.org/article/e0b73413a8b84839b52787d2c52d8107
Autor:
Kouji Kajinami, Margaret E. Brousseau, Chorthip Nartsupha, Jose M. Ordovas, Ernst J. Schaefer
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 4, Pp 653-656 (2004)
The mechanisms responsible for interindividual variation in response to statin therapy remain uncertain. It has been shown that hepatic cholesterol synthesis is associated with ATP binding cassette transporter G5 and G8 (ABCG5/8) activities. To test
Externí odkaz:
https://doaj.org/article/fd977c0b60b4447a9a36af89fb221ada
Autor:
Margaret E. Brousseau, Gretchen P. Eberhart, Josée Dupuis, Bela F. Asztalos, Allison L. Goldkamp, Ernst J. Schaefer, Mason W. Freeman
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 7, Pp 1125-1135 (2000)
Tangier disease (TD), caused by mutations in the ATP-binding cassette 1 (ABC-1) gene, is a rare genetic disorder characterized by severe deficiency of high density lipoproteins (HDL) in the plasma, hypercatabolism of HDL, and defective apolipoprotein
Externí odkaz:
https://doaj.org/article/953e0aab55ba427798c3141b7e7c1d65