Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Margaret Dykes-Hoberg"'
Autor:
Mitsunori Watanabe, Margaret Dykes-Hoberg, Valeria Cizewski Culotta, Donald L. Price, Philip C. Wong, Jeffrey D. Rothstein
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 6, Pp 933-941 (2001)
The mechanisms leading to neurodegeneration in ALS (amyotrophic lateral sclerosis) are not well understood, but cytosolic protein aggregates appear to be common in sporadic and familial ALS as well as transgenic mouse models expressing mutant Cu/Zn s
Externí odkaz:
https://doaj.org/article/9eb5061da769401186e6a95b7c012682
Autor:
Melissa R. Regan, Dwight E. Bergles, Andrew M. Watkins, Jeffrey D. Rothstein, Yu Shin Kim, Yanhua H. Huang, Lin Jin, Margaret Dykes-Hoberg
Publikováno v:
Journal of Neuroscience. 27:6607-6619
Glutamate transporters regulate excitatory neurotransmission and prevent glutamate-mediated excitotoxicity in the CNS. To better study the cellular and temporal dynamics of the expression of these transporters, we generated bacterial artificial chrom
Autor:
Pankaj Gupta, Jeffrey D. Rothstein, Dwight E. Bergles, Yanhua H. Huang, Lin Jin, Zao-Zhong Su, Lucie I. Bruijn, Svetlana Vidensky, Christine Haenggeli, Paul B. Fisher, Dorothy S. Chung, Margaret Dykes Hoberg, Sarjubhai Patel, Shuy Vang Toan, Melissa R. Regan
Publikováno v:
Nature. 433:73-77
Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of synaptic glutamate is handled by the glutamate transporter GLT1 (also known as EAAT2; refs 1, 2), the physiologically dominant astroglial protein. In spite
Publikováno v:
Annals of Neurology. 55:469-477
Functional studies suggest that up to 95% of all glutamate transport is handled by the glutamate transporter EAAT2. Amino and C-terminal antibodies demonstrate that under normal conditions EAAT2 is specific to astrocytes. A truncated splice variant o
Autor:
Valeria C. Culotta, Donald L. Price, Philip C. Wong, Mitsunori Watanabe, Margaret Dykes-Hoberg, Jeffrey D. Rothstein
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 6, Pp 933-941 (2001)
The mechanisms leading to neurodegeneration in ALS (amyotrophic lateral sclerosis) are not well understood, but cytosolic protein aggregates appear to be common in sporadic and familial ALS as well as transgenic mouse models expressing mutant Cu/Zn s
Autor:
Devin Franklin Welty, Lin Jin, Yanfeng Wang, Matthias A. Hediger, Margaret Dykes-Hoberg, Lynn A. Bristol, Carlos A. Pardo, Jeffrey D. Rothstein, Yoshikatsu Kanai, Ralph W. Kuncl, Jerry P Schielke
Publikováno v:
Neuron. 16:675-686
Three glutamate transporters have been identified in rat, including astroglial transporters GLAST and GLT-1 and a neuronal transporter EAAC1. Here we demonstrate that inhibition of the synthesis of each glutamate transporter subtype using chronic ant
Publikováno v:
Proceedings of the National Academy of Sciences. 90:6591-6595
Defects in neurotransmitter glutamate transport may be an important component of chronic neurotoxicity in diseases such as amyotrophic lateral sclerosis. There are no reliable models of slow glutamate neurotoxicity. Most previous in vitro systems hav
Autor:
Yanhua H. Huang, Kohichi Tanaka, Jeffrey D. Rothstein, Dwight E. Bergles, Margaret Dykes-Hoberg
Cerebellar Purkinje cells (PCs) express two glutamate transporters, EAAC1 (EAAT3) and EAAT4; however, their relative contribution to the uptake of glutamate at synapses is not known. We found that glutamate transporter currents recorded at climbing f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ee3cae9251555a91ef45257b69eb39
https://europepmc.org/articles/PMC6729555/
https://europepmc.org/articles/PMC6729555/
Autor:
Gabrielle Almer, Krystl Frank, Serge Przedborski, Margaret Dykes-Hoberg, Jeffrey D. Rothstein, Peter Teismann, Daniel B. Drachman
Publikováno v:
Annals of neurology. 52(6)
The pathogenesis of cell death in amyotrophic lateral sclerosis (ALS) may involve glutamate-mediated excitotoxicity, oxidative damage, and apoptosis. We used a transgenic mouse model of ALS to determine the effect of inhibition of cyclooxygenase-2 in
Autor:
Chien Liang G. Lin, Jeffrey D. Rothstein, Wei Song, Lin Jin, Howard J. Federoff, Mu Ya Liu, Margaret Dykes-Hoberg, Paul C. Sternweis, William J. Bowers, Mandy Jackson
Publikováno v:
Nature. 410(6824)
Glutamate is the main excitatory neurotransmitter in the mammalian central nervous system and is removed from the synaptic cleft by sodium-dependent glutamate transporters. To date, five distinct glutamate transporters have been cloned from animal an