Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Margaret Dominska"'
Autor:
Lei Qi, Yang Sui, Xing-Xing Tang, Ryan J McGinty, Xiao-Zhuan Liang, Margaret Dominska, Ke Zhang, Sergei M Mirkin, Dao-Qiong Zheng, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010590 (2023)
Although homologous recombination between transposable elements can drive genomic evolution in yeast by facilitating chromosomal rearrangements, the details of the underlying mechanisms are not fully clarified. In the genome of the yeast Saccharomyce
Externí odkaz:
https://doaj.org/article/e2c144da17f64f8f9a508562b585b3cc
Publikováno v:
eLife, Vol 6 (2017)
In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule. I
Externí odkaz:
https://doaj.org/article/441ded87ce644f0a8ef77f38d9e618c5
Autor:
Sabrina L Andersen, Aimee Zhang, Margaret Dominska, María Moriel-Carretero, Emilia Herrera-Moyano, Andrés Aguilera, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005938 (2016)
The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH complex involved in both nucleotide excision repair (NER) and transcription. Some mutant alleles of RAD3 (rad3-101 and rad3-102)
Externí odkaz:
https://doaj.org/article/4e34bf8082464838a446ffdf70d09c2b
Autor:
Puja Yadav, Victoria Harcy, Juan Lucas Argueso, Margaret Dominska, Sue Jinks-Robertson, Nayun Kim
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004839 (2014)
G-quadruplex or G4 DNA is a non-B secondary DNA structure that comprises a stacked array of guanine-quartets. Cellular processes such as transcription and replication can be hindered by unresolved DNA secondary structures potentially endangering geno
Externí odkaz:
https://doaj.org/article/51d0d0688f224040be6df10ab5e39db8
Autor:
Wei Tang, Margaret Dominska, Patricia W Greenwell, Zachary Harvanek, Kirill S Lobachev, Hyun-Min Kim, Vidhya Narayanan, Sergei M Mirkin, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001270 (2011)
Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeas
Externí odkaz:
https://doaj.org/article/59adf8cdebcf42908eafed207a85a711
Autor:
Phoebe S Lee, Patricia W Greenwell, Margaret Dominska, Malgorzata Gawel, Monica Hamilton, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000410 (2009)
Homologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with heterozygous alleles can produce two homozygous daughter cells (loss of heterozygosity), whereas
Externí odkaz:
https://doaj.org/article/bf248ebbb82946d3a0e29a1a76d46f24
Autor:
Yang Sui, Anastasiya Epstein, Margaret Dominska, Dao-Qiong Zheng, Thomas D Petes, Hannah L Klein
Publikováno v:
Nucleic Acids Research. 50:6890-6902
Ribonucleotides can be incorporated into DNA during replication by the replicative DNA polymerases. These aberrant DNA subunits are efficiently recognized and removed by Ribonucleotide Excision Repair, which is initiated by the heterotrimeric enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f74577fe3e76b86223125c6f18febe6
https://doi.org/10.1093/nar/gkac536
https://doi.org/10.1093/nar/gkac536
Autor:
Elena I. Stepchenkova, Piotr A. Mieczkowski, Thomas A. Kunkel, Adam B. Burkholder, Thomas D. Petes, Denis A. Kiktev, Peter M. J. Burgers, Margaret Dominska, Joseph Dahl, Scott A. Lujan, Tony Zhang
Publikováno v:
Nucleic Acids Research
Iron-sulfur clusters (4Fe–4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic activity is not fully understood. We identified the MET18 (MMS19) gene of Saccharomyces cerevisiae as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8d3cda85e55d05e987d2244cf4b037
http://europepmc.org/articles/PMC8191807
http://europepmc.org/articles/PMC8191807
Autor:
Margaret Dominska, Thomas D. Petes, Alexander J. Neil, Rachel G. Rubinstein, Sergei M. Mirkin, Ryan J. McGinty, Denis A. Kiktev
Publikováno v:
Genome Research. 27:2072-2082
Improper DNA double-strand break (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congenital disorders in humans. Trinucleotide repeat sequences, such as (GAA)n repeats in Friedreich's ataxia, (CTG)n repeats i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3372f6101a3bf4eb031689101205076c
https://doi.org/10.1101/gr.228148.117
https://doi.org/10.1101/gr.228148.117
Autor:
Margaret Dominska, Thomas D. Petes, Robert J. Kokoska, Ying Zhao, Aleksandra Petrova, Halle Bagshaw
Publikováno v:
Genetics. 206:785-800
In the yeast Saccharomyces cerevisiae, the genes encoding the metallothionein protein Cup1 are located in a tandem array on chromosome VIII. Using a diploid strain that is heterozygous for an insertion of a selectable marker (URA3) within this tandem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06fae7df363cab118dce8d98657ac9a2
https://doi.org/10.1534/genetics.117.201285
https://doi.org/10.1534/genetics.117.201285