Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Margaret Coughlin"'
Autor:
Adrian R. Wilkie, Mayuri Sharma, Margaret Coughlin, Jean M. Pesola, Maria Ericsson, Jessica L. Lawler, Rosio Fernandez, Donald M. Coen
Publikováno v:
Viruses, Vol 14, Iss 3, p 479 (2022)
After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane (INM) for nuclear egress. For human cytomegalovirus (HCMV), capsid migration depends at least i
Externí odkaz:
https://doaj.org/article/e39719dd82174bc5a893f9754d9d1d26
Autor:
Vincent C. Tam, Masato Suzuki, Margaret Coughlin, David Saslowsky, Kuntal Biswas, Wayne I. Lencer, Shah M. Faruque, John J. Mekalanos
Publikováno v:
mBio, Vol 1, Iss 5 (2010)
ABSTRACT Vibrio cholerae, a Gram-negative facultative pathogen, is the etiologic agent for the diarrheal disease cholera. We previously characterized a clinical isolate, AM-19226, that translocates a type III secretion system (T3SS) effector protein
Externí odkaz:
https://doaj.org/article/e950562463b443358e9a912b6294e737
Autor:
Patrick Jurewicz, James M. Mensch, Susan W. Yeargin, Monica R. Lininger, Matthew M. Moore, Rebecca M. Hirschhorn, Margaret Coughlin, Hayley E. O'Connell
Publikováno v:
Annals of Biomedical Engineering. 49:2924-2931
Improper helmet fit is related to sport-related concussion symptomology. The objective of this study was to determine the prevalence of improperly fit helmets in American youth tackle football players across one competitive season. Four recreation le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d3af99ef106d97dc85185f6e3cae40
https://doi.org/10.1007/s10439-021-02817-9
https://doi.org/10.1007/s10439-021-02817-9
Publikováno v:
Proceedings of the National Academy of Sciences. 116:11444-11453
As 3D culture has become central to investigation of tissue biology, mammary epithelial organoids have emerged as powerful tools for investigation of epithelial cell polarization and carcinogenesis. However, most current protocols start from single c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d071406bfd470056eff9cab2635f70
https://doi.org/10.1073/pnas.1702372116
https://doi.org/10.1073/pnas.1702372116
Autor:
Susan W, Yeargin, Monica R, Lininger, Margaret, Coughlin, Rebecca M, Hirschhorn, Patrick, Jurewicz, Matthew, Moore, Hayley, O'Connell, James, Mensch
Publikováno v:
Annals of biomedical engineering. 49(10)
Improper helmet fit is related to sport-related concussion symptomology. The objective of this study was to determine the prevalence of improperly fit helmets in American youth tackle football players across one competitive season. Four recreation le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db10f276ccf69f9546d747aac33f2440
https://pubmed.ncbi.nlm.nih.gov/34389900
https://pubmed.ncbi.nlm.nih.gov/34389900
Autor:
Margaret Coughlin, Christine M. Field, Martin Wühr, Matthew Sonnett, Lillia V. Ryazanova, Timothy J. Mitchison, James F. Pelletier
Crowding increases the tendency of macromolecules to aggregate and phase separate, and high crowding can induce glass-like states of cytoplasm. To explore the effect of crowding in a well-characterized model cytoplasm we developed methods to selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580b72732eea8a64abee9cb4032b42d9
https://doi.org/10.1101/2021.04.11.439352
https://doi.org/10.1101/2021.04.11.439352
Autor:
J. Wade Harper, Joao A. Paulo, Jin-Mi Heo, Nathan J. Harper, Stephen J. Elledge, Mamie Li, Margaret Coughlin, Qikai Xu
Publikováno v:
Science Advances
We explore the landscape of a mitochondrial-autophagosome synapse during mitophagy using proteomics and genetic screens.
The PINK1 protein kinase activates the PARK2 ubiquitin ligase to promote mitochondrial ubiquitylation and recruitment of ubi
The PINK1 protein kinase activates the PARK2 ubiquitin ligase to promote mitochondrial ubiquitylation and recruitment of ubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e86a117fa6816ef231462ec9dd677b8
https://doi.org/10.1126/sciadv.aay4624
https://doi.org/10.1126/sciadv.aay4624
Autor:
Martine Ruer, Timothy J. Mitchison, Elvan Boke, Anthony A. Hyman, Martin Wühr, Steven P. Gygi, David N. Drechsel, Margaret Coughlin, Regis P. Lemaitre, Simon Alberti
Publikováno v:
Cell. 166:637-650
Most vertebrate oocytes contain a Balbiani body, a large, non-membrane-bound compartment packed with RNA, mitochondria, and other organelles. Little is known about this compartment, though it specifies germline identity in many non-mammalian vertebra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bde0d1e21288f2b9aa6361c1078949a
https://doi.org/10.1016/j.cell.2016.06.051
https://doi.org/10.1016/j.cell.2016.06.051
Autor:
Martin Wühr, Elizabeth Van Itallie, Steven P. Gygi, Margaret Coughlin, Marc W. Kirschner, Allon M. Klein, Marc Presler, Ryan C. Kunz, Leonid Peshkin
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Fertilization releases the meiotic arrest and initiates the events that prepare the egg for the ensuing developmental program. Protein degradation and phosphorylation are known to regulate protein activity during this process. However, the full exten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea87a060be3b62ff6d0d2e380f93a47a
https://doi.org/10.1073/pnas.1709207114
https://doi.org/10.1073/pnas.1709207114
Autor:
Sergi Garcia-Manyes, Eleonora Muro, Ulrike S. Eggert, Anne V. Bedigian, Sofia Sasse, Margaret Coughlin, G. Ekin Atilla-Gokcumen, Josep Relat-Goberna
Publikováno v:
Cell
Atilla-Gokcumen, G E, Muro, E, Relat-Goberna, J, Sasse, S, Bedigian, A, Coughlin, M L, Garcia-Manyes, S & Eggert, U S 2014, ' Dividing cells regulate their lipid composition and localization ', Cell, vol. 156, no. 3, pp. 428-439 . https://doi.org/10.1016/j.cell.2013.12.015
Atilla-Gokcumen, G E, Muro, E, Relat-Goberna, J, Sasse, S, Bedigian, A, Coughlin, M L, Garcia-Manyes, S & Eggert, U S 2014, ' Dividing cells regulate their lipid composition and localization ', Cell, vol. 156, no. 3, pp. 428-439 . https://doi.org/10.1016/j.cell.2013.12.015
Summary Although massive membrane rearrangements occur during cell division, little is known about specific roles that lipids might play in this process. We report that the lipidome changes with the cell cycle. LC-MS-based lipid profiling shows that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67130c0854d4f7f41ea2e6db390c3215
http://europepmc.org/articles/PMC3909459
http://europepmc.org/articles/PMC3909459