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Autor:
Gino Gabellone, Lloyd Charles Franklin, Thomas Norman Nanninga, Lisa M. Reeder, Niamh J. Panesar, Kyle Kissick, Catherine Dunne, Stuart Field, Martinez Carlos, John W. Wong, George Smith, James Saenz, Margaret Claire Evans, Lorraine Murtagh, John G. Van Alsten
Publikováno v:
Organic Process Research & Development. 15:1315-1327
Three synthetic approaches, suitable for the large scale manufacture of the α2δ-ligand, (3S,5R)-3-(aminomethyl)-5-methyloctanoic acid 3, have been evaluated. The selected seven step manufacturing process has then been optimized and used to deliver