Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Margaret C. Dunn"'
Autor:
Jitesh P. Jani, Gerrit Los, Kajiji Shama M, Bruce D. Cohen, Green Larry L, Kevin Coleman, Mary Campbell, Jinghai J. Xu, Elsa G. Barbacci-Tobin, Vahe Bedian, Konstantinos Tsaparikos, Jean-Martin Lapointe, Patrick Vincent, Boris A. Chrunyk, Neil R. Michaud, Stephen M. Hillerman, David F. Gebhard, Tim M. Coskran, George A. Karam, Margaret C. Dunn, Elisabeth Knauth, Stefan J. Steyn, Henry Putz, Gary Borzillo
Publikováno v:
mAbs. 4:710-723
The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by its ligand, hepatocyte growth factor (HGF), to induce cell growth, motility and morphogenesis. Dysregulation of c-Met function, through mutational activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7724a3acb9187edf4bc1c797bd35ec1f
https://doi.org/10.4161/mabs.22160
https://doi.org/10.4161/mabs.22160
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 12:827-837
Efficiency and accuracy in addressing drug safety issues proactively are critical in minimizing late-stage drug attritions. Discovery Toxicology has become a specialty subdivision of Toxicology seeking to effectively provide early predictions and saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85df2e8db159e440ebcab7e6b3698d69
https://doi.org/10.2174/138620709789383268
https://doi.org/10.2174/138620709789383268
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 795
Kinases are members of a major protein family targeted for drug discovery and development. Given the ubiquitous nature of many kinases as well as the broad range of pathways controlled by these enzymes, early safety assessments of small molecule inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7a5170227724ed9c78d12544dd85594
https://pubmed.ncbi.nlm.nih.gov/21960217
https://pubmed.ncbi.nlm.nih.gov/21960217
Publikováno v:
Methods in Molecular Biology ISBN: 9781617793363
Kinases are members of a major protein family targeted for drug discovery and development. Given the ubiquitous nature of many kinases as well as the broad range of pathways controlled by these enzymes, early safety assessments of small molecule inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::305562501b8e54a4b2b1c226e40407c7
https://doi.org/10.1007/978-1-61779-337-0_6
https://doi.org/10.1007/978-1-61779-337-0_6
Autor:
Jinghai J. Xu, David B. Duignan, Vsevolod E. Kostrubsky, Margaret C. Dunn, Huifen F. Wang, Rouchelle J. Mireles, Ralph E. Davidson, Scott D. Campbell, Yi-an Bi, Arthur R. Smith, Bo Feng
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 108(2)
CP-724,714, a potent and selective orally active HER2 tyrosine kinase inhibitor, was discontinued from clinical development due to unexpected hepatotoxicity in cancer patients. Based on the clinical manifestation of the toxicity, CP-724,714 likely ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b354c712ba1dc60d4a3ca11146bcda3
https://pubmed.ncbi.nlm.nih.gov/19223659
https://pubmed.ncbi.nlm.nih.gov/19223659
Autor:
David de Graaf, Peter V. Henstock, Arthur R. Smith, Jeffrey R. Chabot, Margaret C. Dunn, Jinghai J. Xu
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 105(1)
Drug-induced liver injury (DILI) is the most common adverse event causing drug nonapprovals and drug withdrawals. Using drugs as test agents and measuring a panel of cellular phenotypes that are directly linked to key mechanisms of hepatotoxicity, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b60568bad99926297b6d932cecee36
https://pubmed.ncbi.nlm.nih.gov/18524759
https://pubmed.ncbi.nlm.nih.gov/18524759
Autor:
Sashi Nadanaciva, Arthur R. Smith, Lisa D. Marroquin, Margaret C. Dunn, James A. Dykens, Yvonne Will, Joseph D. Jamieson, Jinghai J. Xu
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 103(2)
Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S. market in 2004 due to hepatotoxicity. Accordingly, we evaluated nefazodone, another triazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c324a18a7187f89351b80429024aade8
https://pubmed.ncbi.nlm.nih.gov/18344530
https://pubmed.ncbi.nlm.nih.gov/18344530
Autor:
Bo Feng, Jinghai J. Xu, Yi-An Bi, Rouchelle Mireles, Ralph Davidson, David B. Duignan, Scott Campbell, Vsevolod E. Kostrubsky, Margaret C. Dunn, Arthur R. Smith, Huifen F. Wang
Publikováno v:
Toxicological Sciences; Apr2009, Vol. 108 Issue 2, p492-500, 9p
Autor:
Jinghai J. Xu, Peter V. Henstock, Margaret C. Dunn, Arthur R. Smith, Jeffrey R. Chabot, David de Graaf
Publikováno v:
Toxicological Sciences; Sep2008, Vol. 105 Issue 1, p97-97, 1p
Autor:
James A. Dykens, Joseph D. Jamieson, Lisa D. Marroquin, Sashi Nadanaciva, Jinghai J. Xu, Margaret C. Dunn, Arthur R. Smith, Yvonne Will
Publikováno v:
Toxicological Sciences; Jun2008, Vol. 103 Issue 2, p335-335, 1p