Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Margaret C M, Smith"'
Autor:
Hong Gao, Buvani Murugesan, Janina Hoßbach, Stephanie K. Evans, W. Marshall Stark, Margaret C. M. Smith
Publikováno v:
BMC Biotechnology, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Few natural product pathways from rare Actinomycetes have been studied due to the difficulty in applying molecular approaches in these genetically intractable organisms. In this study, we sought to identify more integrating vector
Externí odkaz:
https://doaj.org/article/718f25bbf7474f3f9867bb7fa0824f00
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic unders
Externí odkaz:
https://doaj.org/article/0206d37f853f4eb0897bee9dba11785e
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT The physiological role of protein O-glycosylation in prokaryotes is poorly understood due to our limited knowledge of the extent of their glycoproteomes. In Actinobacteria, defects in protein O-mannosyl transferase (Pmt)-mediated protein O-g
Externí odkaz:
https://doaj.org/article/4b7b52cead9a4c08b3aba7c563e3e979
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e2006057 (2018)
Phages shape the structure of natural bacterial communities and can be effective therapeutic agents. Bacterial resistance to phage infection, however, limits the usefulness of phage therapies and could destabilise community structures, especially if
Externí odkaz:
https://doaj.org/article/eea8df8076dc4f3496f2bc186799cf56
Publikováno v:
Synthetic and Systems Biotechnology, Vol 5, Iss 2, Pp 111-119 (2020)
Synthetic and Systems Biotechnology
Synthetic and Systems Biotechnology
Serine integrases have been shown to be efficient tools for metabolic pathway assembly. To further improve the flexibility and efficiency of pathway engineering via serine integrases, we explored how multiple orthogonally active serine integrases can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12792234e51be9887aebb5e1ce0a090c
https://doi.org/10.1016/j.synbio.2020.05.006
https://doi.org/10.1016/j.synbio.2020.05.006
Autor:
Hong Gao, Margaret C. M. Smith
Publikováno v:
Access Microbiology
Some major producers of useful bioactive natural products belong to the genus Streptomyces or related actinobacteria. Genetic engineering of these bacteria and the pathways that synthesize their valuable products often relies on serine integrases. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bee982fee37a39c445ff31178eddd1
http://europepmc.org/articles/PMC8749152
http://europepmc.org/articles/PMC8749152
Publikováno v:
Microbiology
In Actinobacteria , protein O-mannosyl transferase (Pmt)-mediated protein O-glycosylation has an important role in cell envelope physiology. In S. coelicolor, defective Pmt leads to increased susceptibility to cell wall-targeting antibiotics, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53209badaab399794972b04c21fee0e4
https://eprints.whiterose.ac.uk/182102/1/mic001103.pdf
https://eprints.whiterose.ac.uk/182102/1/mic001103.pdf
Publikováno v:
Wright, R C T, Friman, V, Smith, M C M & Brockhurst, M A 2021, ' Functional diversity increases the efficacy of phage combinations ', Microbiology, vol. 167, no. 12 . https://doi.org/10.1099/mic.0.001110
Microbiology
Microbiology
Phage therapy is a promising alternative to traditional antibiotics for treating bacterial infections. Such phage-based therapeutics typically contain multiple phages, but how the efficacy of phage combinations scales with phage richness, identity an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58003a4af52ffc1de7069578773eb3aa
https://doi.org/10.1101/2021.07.09.451746
https://doi.org/10.1101/2021.07.09.451746
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54316 (2013)
Branching networks are ubiquitous in nature and their growth often responds to environmental cues dynamically. Using the antibiotic-producing soil bacterium Streptomyces as a model we have developed a flexible mathematical model platform for the stud
Externí odkaz:
https://doaj.org/article/e6ee5cd1cc3d4153b006b401f41ba744
Publikováno v:
Microbiology (Reading, England). 165(2)
Actinomycete bacteria use polyprenol phosphate mannose as a lipid-linked sugar donor for extra-cytoplasmic glycosyl transferases that transfer mannose to cell envelope polymers, including glycoproteins and glycolipids. Strains of Streptomyces coelico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdedcc6b073f9b0719ed7538b86a07b
https://pubmed.ncbi.nlm.nih.gov/30632959
https://pubmed.ncbi.nlm.nih.gov/30632959