Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Margaret C Frame"'
Autor:
Emily R Webb, Georgia L Dodd, Michaela Noskova, Esme Bullock, Morwenna Muir, Margaret C Frame, Alan Serrels, Valerie G Brunton
Publikováno v:
eLife, Vol 12 (2023)
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated with metastasis-free survival; however, the mechanisms involved are poorly understood. Here, we report that Kindlin-1 promotes anti-tumor immune evasion in mouse
Externí odkaz:
https://doaj.org/article/c3ca53b8a4394469ab79acf4dee4d370
Autor:
Christina Schoenherr, Adam Byron, Emma Sandilands, Ketevan Paliashvili, George S Baillie, Amaya Garcia-Munoz, Cristina Valacca, Francesco Cecconi, Bryan Serrels, Margaret C Frame
Publikováno v:
eLife, Vol 6 (2017)
Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src
Externí odkaz:
https://doaj.org/article/7aa48c44f5304c8d82115c88d5b94df4
Autor:
Simon Wilkinson, Margaret C Frame
Publikováno v:
eLife, Vol 5 (2016)
A new study reveals that the ROCK proteins play key roles in the formation of tumours in mice.
Externí odkaz:
https://doaj.org/article/61879ce896d142f4920536ae5e7ca015
Autor:
Kristin A Sauter, Clare Pridans, Anuj Sehgal, Calum C Bain, Charlotte Scott, Lindsey Moffat, Rocío Rojo, Ben M Stutchfield, Claire L Davies, David S Donaldson, Kathleen Renault, Barry W McColl, Alan M Mowat, Alan Serrels, Margaret C Frame, Neil A Mabbott, David A Hume
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105429 (2014)
The MacBlue transgenic mouse uses the Csf1r promoter and first intron to drive expression of gal4-VP16, which in turn drives a cointegrated gal4-responsive UAS-ECFP cassette. The Csf1r promoter region used contains a deletion of a 150 bp conserved re
Externí odkaz:
https://doaj.org/article/c067773fe90546c5b51bad1acbccb34b
Autor:
Arkadiusz Welman, Duncan Sproul, Peter Mullen, Morwenna Muir, Andrew R Kinnaird, David J Harrison, Dana Faratian, Valerie G Brunton, Margaret C Frame
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34182 (2012)
Overexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear. We analysed matriptase expression in 16 human breast
Externí odkaz:
https://doaj.org/article/f68ec75a6d1b45c7a524d4794a4d5dae
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27806 (2011)
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is elevated in a variety of human cancers. While FAK is implicated in many cellular processes that are perturbed in cancer, including proliferation, actin and adhesion dynamics, polari
Externí odkaz:
https://doaj.org/article/48dd49013c8b4540a152d7bd3a33a798
Autor:
Joëlle Mounier, Michel R Popoff, Jost Enninga, Margaret C Frame, Philippe J Sansonetti, Guy Tran Van Nhieu
Publikováno v:
PLoS Pathogens, Vol 5, Iss 1, p e1000271 (2009)
Shigella, the causative agent of bacillary dysentery, invades epithelial cells by locally reorganizing the actin cytoskeleton. Shigella invasion requires actin polymerization dependent on the Src tyrosine kinase and a functional bacterial type III se
Externí odkaz:
https://doaj.org/article/d87708bffbbe44bc9edc3b95dbbc2f33
Autor:
Helen F. Titmarsh, Alex von Kriegsheim, Jimi C. Wills, Richard A. O’Connor, Kevin Dhaliwal, Margaret C. Frame, Samuel B. Pattle, David A. Dorward, Adam Byron, Ahsan R. Akram
Publikováno v:
Titmarsh, H F, Von Kriegsheim, A, Wills, J C, O'Connor, R A, Dhaliwal, K, Frame, M C, Pattle, S B, Dorward, D A, Byron, A & Akram, A R 2023, ' Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer ', Frontiers in Oncology, vol. 13 . https://doi.org/10.3389/fonc.2023.1194515
The composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through multiple mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8df6b55b9af2f367854f40dc2043890
https://research.manchester.ac.uk/en/publications/2d8e7666-8e4c-474a-8e48-e7df086e22d5
https://research.manchester.ac.uk/en/publications/2d8e7666-8e4c-474a-8e48-e7df086e22d5
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
Quantification of YAP localization in esophageal cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeaefc45ec2edeaa334529edbfcd1f4
https://doi.org/10.1158/1535-7163.22506288.v1
https://doi.org/10.1158/1535-7163.22506288.v1
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
We mutated the focal adhesion kinase (FAK) catalytic domain to inhibit binding of the chaperone Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We reexpressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d91c39eb635f3918725cf611b30b136
https://doi.org/10.1158/1535-7163.c.6538347
https://doi.org/10.1158/1535-7163.c.6538347