Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Margaret A. Twomey"'
Autor:
Margaret A. Twomey, Jayalakshmi Miriyala, Mark J. Zylka, Angela M. Mabb, Benjamin D. Philpot, Paul H. M. Kullmann
Publikováno v:
Proceedings of the National Academy of Sciences. 111:17290-17295
Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that topotecan reduces the expression of multiple long genes, including many neuronal genes linked to synapses and autism. However, wheth
Autor:
Annakaisa Herrala, Margaret A. Twomey, Vootele Voikar, Pirkko Vihko, Bonnie Taylor-Blake, Mark J. Zylka, Nathaniel A. Sowa
Publikováno v:
Neuron. 60:111-122
Summary Thiamine monophosphatase (TMPase, also known as fluoride-resistant acid phosphatase) is a classic histochemical marker of small-diameter dorsal root ganglia neurons. The molecular identity of TMPase is currently unknown. We found that TMPase
Autor:
Sergey Chasovskikh, Andrew Mittereder, Timothy R. Mhyre, Vy Ton, Kathleen A. Maguire-Zeiss, Dawn Béraud, Margaret A. Twomey, Benjamin Bloom, Katherine Neitzke
Publikováno v:
Frontiers in Neuroscience, Vol 5 (2011)
Frontiers in Neuroscience
Frontiers in Neuroscience
Parkinson’s disease, an age-related neurodegenerative disorder, is characterized by the loss of dopamine neurons in the substantia nigra, the accumulation of α-synuclein in Lewy bodies and neurites, and neuroinflammation. While the exact etiology
Autor:
Brian C. Kovaric, Julio C. de Paula, Bashkim Kokona, Margaret A. Twomey, Alexander D. Schwab, Robert Fairman
Publikováno v:
Journal of the American Chemical Society. 128:4166-4167
The anionic porphyrin, meso-tetrakis(4-sulfonatophenyl)porphine, is found to tightly bind to an engineered 14-residue peptide, resulting in induced alpha-helix formation when mixed in aqueous solutions. The small porphyrin-peptide dissociation consta