Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Margaret A. Owegi"'
Autor:
Merit E. Cudkowicz, Stacy R. Lindborg, Namita A. Goyal, Robert G. Miller, Matthew J. Burford, James D. Berry, Katharine A. Nicholson, Tahseen Mozaffar, Jonathan S. Katz, Liberty J. Jenkins, Robert H. Baloh, Richard A. Lewis, Nathan P. Staff, Margaret A. Owegi, Donald A. Berry, Yael Gothelf, Yossef S. Levy, Revital Aricha, Ralph Z. Kern, Anthony J. Windebank, Robert H. Brown
Publikováno v:
Muscle & Nerve. 65:291-302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e662eb8a40ca42836183df1563ce60d
https://doi.org/10.1002/mus.27472
https://doi.org/10.1002/mus.27472
Autor:
Nicholas Wightman, Merit Cudkowicz, Margaret A. Owegi, Dario Gelevski, Gwladys Gernoux, Meghan Blackwood, Christian Mueller, James D. Berry, Sarah Luppino, Catherine Douthwright, Robert H. Brown, Terrence R. Flotte, Derek H. Oakley, Diane McKenna-Yasek, Lindsay Pothier, Matthew P. Frosch
Publikováno v:
New England Journal of Medicine. 383:151-158
Two patients with familial amyotrophic lateral sclerosis (ALS) and mutations in the gene encoding superoxide dismutase 1 (SOD1) were treated with a single intrathecal infusion of adeno-associated virus encoding a microRNA targeting SOD1. In Patient 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f616bbeff3f5d1853c06edb19934f1bc
https://doi.org/10.1056/nejmoa2005056
https://doi.org/10.1056/nejmoa2005056
Autor:
Sabrina Paganoni, Suzanne Hendrix, Samuel P Dickson, Newman Knowlton, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret Ayo Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry D Heiman-Patterson, Carlayne Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq S Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina Fournier, Kristin M Johnson, Andrea Swenson, Namita Goyal, Gary L Pattee, Suma Babu, Marianne Chase, Derek Dagostino, Meghan Hall, Gale Kittle, Mathew Eydinov, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Eric Tustison, Prasha Vigneswaran, Hong Yu, Joshua Cohen, Justin Klee, Rudolph Tanzi, Walter Gilbert, Patrick Yeramian, Merit Cudkowicz
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry, vol 93, iss 8
BackgroundCoformulated sodium phenylbutyrate/taurursodiol (PB/TURSO) was shown to prolong survival and slow functional decline in amyotrophic lateral sclerosis (ALS).ObjectiveDetermine whether PB/TURSO prolonged tracheostomy/ventilation-free survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668333e30d83e12f19bd834ace7127dc
https://pubmed.ncbi.nlm.nih.gov/35577511
https://pubmed.ncbi.nlm.nih.gov/35577511
Autor:
Colin Quinn, Corey T. McMillan, Namita Goyal, Kelly Almasy, Diane McKenna-Yasek, Margaret A. Owegi, Catherine Douthwright, James D. Berry, Robert H. Brown
Publikováno v:
Amyotrophic lateral sclerosisfrontotemporal degeneration. 22(sup1)
Objective: To measure the correlation between single breath counting (SBC) and forced vital capacity (liters, FVCL) in amyotrophic lateral sclerosis (ALS) patients and to define the utility of SBC ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fae34029031007dff36d7639416242
https://pubmed.ncbi.nlm.nih.gov/34348533
https://pubmed.ncbi.nlm.nih.gov/34348533
Autor:
Sonia Boodram, Amber Salter, Robert H. Baloh, Diane McKenna-Yasek, Matthew B. Harms, Thomas J. Esparza, Theodore Hyman, Robert H. Brown, Caroline Drain, Nicholas Wightman, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Leonard H. van den Berg, Toby A. Ferguson, Jan H. Veldink, Alexander Sherman, Michael A. van Es, Hong Yu, Catherine Douthwright, Jennifer Jockel-Balsarotti, Merit Cudkowicz, Alexander McCampbell, Margaret A. Owegi, Timothy M. Miller, Nazem Atassi, Amber Malcolm, Alexander J. Cammack, Bálint S de Vries, Jeffrey D. Rothstein
Publikováno v:
Neurology. 93:e1605-e1617
ObjectiveTo define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies.MethodsWe prospectively collected clinical and demographic data from 116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc96232b3c87150081db892edd8e7c7
https://doi.org/10.1212/wnl.0000000000008359
https://doi.org/10.1212/wnl.0000000000008359
Autor:
Michael A. Elliott, Jeffrey D. Rothstein, Joshua D. Cohen, Kent Allen Hendrix, Stephen A. Goutman, James D. Berry, Jeremy M. Shefner, Terry Heiman-Patterson, Patrick D. Yeramian, Andrea Swenson, Janet Wittes, Samuel P. Dickson, Patricia L. Andres, Tuan Vu, Samuel Maiser, Rudolph E. Tanzi, Rebecca Randall, Christina Fournier, Merit Cudkowicz, Joseph Ostrow, Suzanne Hendrix, James Wymer, Liberty Jenkins, Jonathan S. Katz, Daragh Heitzman, Alexander Sherman, Colin Quinn, Chafic Karam, Michelle McGovern, Derek Dagostino, Timothy M. Miller, Stephen N. Scelsa, Marianne Chase, Jason Walker, Edward J. Kasarskis, Eric A. Macklin, Margaret A. Owegi, Shafeeq Ladha, Lindsay Pothier, Adam Quick, Meghan Hall, Noel Ellison, James Chan, Suma Babu, Gary L. Pattee, Kristin M. Johnson, Prasha Vigneswaran, Walter Gilbert, James B. Caress, David A. Schoenfeld, Eric Tustison, Kent L. Leslie, Namita Goyal, Gale Kittle, Carlayne E. Jackson, Sabrina Paganoni, Jonathan D. Glass, Justin Klee, Hong Yu
Publikováno v:
N Engl J Med
The New England journal of medicine, vol 383, iss 10
The New England journal of medicine, vol 383, iss 10
BACKGROUND: Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal death in experimental models. The efficacy and safety of a combination of the two compounds in persons with amyotrophic lateral sclerosis (ALS) are not known. METHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52826091fd3ec45497530d4a5ecba969
https://pubmed.ncbi.nlm.nih.gov/33931772
https://pubmed.ncbi.nlm.nih.gov/33931772
Publikováno v:
Clinical Imaging. 48:22-25
Anoxic brain injury can manifest with various abnormal movements. We describe acute chorea in a young patient with anoxic brain injury due to chlordiazepoxide toxicity who had delayed radiographic lesions in bilateral globus pallidus. Although brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74980317d633d4d077f933d9efd94b85
https://doi.org/10.1016/j.clinimag.2017.10.004
https://doi.org/10.1016/j.clinimag.2017.10.004
Autor:
Anthony J. Windebank, Margaret A. Owegi, Nathan P. Staff, Diane McKenna-Yasek, Merit Cudkowicz, Yael Gothelf, James D. Berry, Haggai Kaspi, Katherine Nicholson, Robert H. Brown, Munish Mehra, Y.S. Levy, Natalie Abramov, Revital Aricha
Publikováno v:
Neurology. 93(24)
ObjectiveTo determine the safety and efficacy of mesenchymal stem cell (MSC)-neurotrophic factor (NTF) cells (NurOwn®, autologous bone marrow-derived MSCs, induced to secrete NTFs) delivered by combined intrathecal and intramuscular administration t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c5be0411a540980f8a193a379cd3d5
https://pubmed.ncbi.nlm.nih.gov/31740544
https://pubmed.ncbi.nlm.nih.gov/31740544
Autor:
Alexander J, Cammack, Nazem, Atassi, Theodore, Hyman, Leonard H, van den Berg, Matthew, Harms, Robert H, Baloh, Robert H, Brown, Michael A, van Es, Jan H, Veldink, Balint S, de Vries, Jeffrey D, Rothstein, Caroline, Drain, Jennifer, Jockel-Balsarotti, Amber, Malcolm, Sonia, Boodram, Amber, Salter, Nicholas, Wightman, Hong, Yu, Alexander V, Sherman, Thomas J, Esparza, Diane, McKenna-Yasek, Margaret A, Owegi, Catherine, Douthwright, Alexander, McCampbell, Toby, Ferguson, Carlos, Cruchaga, Merit, Cudkowicz, Timothy M, Miller
Publikováno v:
Neurology
OBJECTIVE: To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS: We prospectively collected clinical and demographic data from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b46b32177bb46a54b63a1cc415d8531
https://pubmed.ncbi.nlm.nih.gov/31578300
https://pubmed.ncbi.nlm.nih.gov/31578300
Autor:
Lori J. Jacquemin, Karlett J. Parra, Mark W. Finch, Melissa J. Mertz, Donald Pappas, Jason M. Storms, Craig A. Damin, Katrina L.M. Margalef, Aswathy Warrier, Cruz A. Resendiz, Kathryn M. McCulloch, Sarah Bilbo, Margaret A. Owegi, John D. Trombley
Publikováno v:
Journal of Biological Chemistry. 281:30001-30014
Vacuolar proton-translocating ATPase pumps consist of two domains, V(1) and V(o). Subunit d is a component of V(o) located in a central stalk that rotates during catalysis. By generating mutations, we showed that subunit d couples ATP hydrolysis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f48cf311e1a1c2f546225a1c88a7400
https://doi.org/10.1074/jbc.m605006200
https://doi.org/10.1074/jbc.m605006200