Zobrazeno 1 - 10
of 958
pro vyhledávání: '"Margaret A. Brimble"'
Publikováno v:
ACS Omega, Vol 9, Iss 45, Pp 45624-45632 (2024)
Externí odkaz:
https://doaj.org/article/8786df5f90264cc6a4ba786bba7eb916
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Thanatin is a β-hairpin antimicrobial peptide cyclised by a single disulfide bond that has shown potent broad-spectrum activity towards bacterial and fungal pathogens. Towards Gram-negative species, thanatin acts both by forming trans-membranal pore
Externí odkaz:
https://doaj.org/article/287bc94011e1465898693298a480c6ed
Publikováno v:
Antibiotics, Vol 13, Iss 7, p 615 (2024)
Capitellacin (1) is a 20-residue antimicrobial β-hairpin, produced by the marine polychaeta (segmented worms) Capitella teletai. Since its discovery in 2020, only very limited studies have been undertaken to understand capitellacin’s structure–a
Externí odkaz:
https://doaj.org/article/1c77f25f49b84955a3063602cb7d298c
Publikováno v:
Cells, Vol 13, Iss 9, p 788 (2024)
Norbormide (NRB) is a Rattus-selective toxicant, which was serendipitously discovered in 1964 and formerly marketed as an eco-friendly rodenticide that was deemed harmless to non-Rattus species. However, due to inconsistent efficacy and the emergence
Externí odkaz:
https://doaj.org/article/2b3f345730c942bf805c26147ebad733
Autor:
Dawei Ji, Jingying Ma, Junyi Dai, Min Xu, Paul W. R. Harris, Margaret A. Brimble, Dominic Agyei
Publikováno v:
Dairy, Vol 3, Iss 3, Pp 422-437 (2022)
The drug-likeness and pharmacokinetic properties of 23 dairy-protein-derived opioid peptides were studied using SwissADME and ADMETlab in silico tools. All the opioid peptides had poor drug-like properties based on violations of Lipinski’s rule-of-
Externí odkaz:
https://doaj.org/article/894335f97b88474ba669881a4f39a707
Autor:
Bin Lin, Smitha Nair, Daniel M. J. Fellner, Noha Ahmed Nasef, Harjinder Singh, Leonardo Negron, David C. Goldstone, Margaret A. Brimble, Juliet A. Gerrard, Laura Domigan, Jackie C. Evans, Jonathan M. Stephens, Troy L. Merry, Kerry M. Loomes
Publikováno v:
Foods, Vol 12, Iss 22, p 4072 (2023)
3,6,7-trimethyllumazine (Lepteridine™) is a newly discovered natural pteridine derivative unique to Mānuka (Leptospermum scoparium) nectar and honey, with no previously reported biological activity. Pteridine derivative-based medicines, such as me
Externí odkaz:
https://doaj.org/article/7474211470de49f6811314d0746139e9
Autor:
Alice-Roza Eruera, Alice M. McSweeney, Geena M. McKenzie-Goldsmith, Helen K. Opel-Reading, Simone X. Thomas, Ashley C. Campbell, Louise Stubbing, Andrew Siow, Jonathan G. Hubert, Margaret A. Brimble, Vernon K. Ward, Kurt L. Krause
Publikováno v:
Viruses, Vol 15, Iss 11, p 2202 (2023)
Norovirus is the leading cause of viral gastroenteritis worldwide, and there are no approved vaccines or therapeutic treatments for chronic or severe norovirus infections. The structural characterisation of the norovirus protease and drug development
Externí odkaz:
https://doaj.org/article/86ca3c78c4f045989589594a543e6b57
Publikováno v:
JACS Au, Vol 1, Iss 10, Pp 1527-1540 (2021)
Externí odkaz:
https://doaj.org/article/e3ffc8be592e42679615949dda8e92d8
Autor:
Sin Hang Crystal Chan, Jarred M. Griffin, Connor A. Clemett, Margaret A. Brimble, Simon J. O’Carroll, Paul W. R. Harris
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Peptide5 is a 12–amino acid mimetic peptide that corresponds to a region of the extracellular loop 2 (EL2) of connexin43. Peptide5 regulates both cellular communication with the cytoplasm (hemichannels) and cell-to-cell communication (gap junctions
Externí odkaz:
https://doaj.org/article/cf683c8288674cbf9ee0eb91ff0f3583
Autor:
Aqfan Jamaluddin, Chia-Lin Chuang, Elyse T. Williams, Andrew Siow, Sung Hyun Yang, Paul W. R. Harris, Jakeb S. S. M. Petersen, Rebekah L. Bower, Shanan Chand, Margaret A. Brimble, Christopher S. Walker, Debbie L. Hay, Kerry M. Loomes
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as an
Externí odkaz:
https://doaj.org/article/087bc21e011f479b87b8311010e81136