Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Margaret A. Wheatley"'
Autor:
Quezia Lacerda, Hebah Falatah, Ji-Bin Liu, Corinne E. Wessner, Brian Oeffinger, Ankit Rochani, Dennis B. Leeper, Flemming Forsberg, Joseph M. Curry, Gagan Kaushal, Scott W. Keith, Patrick O’Kane, Margaret A. Wheatley, John R. Eisenbrey
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1302 (2023)
Tumor hypoxia (oxygen deficiency) is a major contributor to radiotherapy resistance. Ultrasound-sensitive microbubbles containing oxygen have been explored as a mechanism for overcoming tumor hypoxia locally prior to radiotherapy. Previously, our gro
Externí odkaz:
https://doaj.org/article/1a19f6f3948d4cdd96820563b7ebdc10
Publikováno v:
Ultrasound Med Biol
Radiation therapy (RT) causes DNA damage through ionization, leading to double-strand breaks. In addition, it generates reactive oxygen species (ROS), which are toxic to tumor cells and the vasculature. However, hypoxic regions in the tumor have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8803a4598f9383f716fb9b3cb5d3d24
https://doi.org/10.1016/j.ultrasmedbio.2021.01.032
https://doi.org/10.1016/j.ultrasmedbio.2021.01.032
Autor:
Raj Patel, Quezia Lacerda, Brian E. Oeffinger, John R. Eisenbrey, Ankit K. Rochani, Gagan Kaushal, Corinne E. Wessner, Margaret A. Wheatley
Publikováno v:
Polymers; Volume 14; Issue 8; Pages: 1568
Co-delivery of cancer therapeutics improves efficacy and encourages synergy, but delivery faces challenges, including multidrug resistance and spatiotemporal distribution of therapeutics. To address these, we added paclitaxel to previously developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81da77943053feb8eb4ae965f5bea48c
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 4, Pp 312-322 (2020)
Research in Pharmaceutical Sciences
Research in Pharmaceutical Sciences
Background and purpose: Lonidamine is a hexokinase II inhibitor, works as an anticancer molecule, and is extensively explored in clinical trials. Limited information prevails about the stability-indicating methods which could determine the forced deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b6c5bd1cfdd80d34fc6e6aad75123d
http://www.rpsjournal.net/article.asp?issn=1735-5362
http://www.rpsjournal.net/article.asp?issn=1735-5362
Autor:
Margaret A. Wheatley, John R. Eisenbrey, Brian E. Oeffinger, Purva B. Vaidya, Iman Ayaz, Rawan Shraim
Publikováno v:
Langmuir. 35:10068-10078
Ultrasound contrast agents consist of stabilized microbubbles. We are developing a surfactant-stabilized microbubble platform with a shell composed of Span 60 (Sorbitan monostearate) and an emulsifying agent, water-soluble vitamin E (α-tocopheryl po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d8d50f913b397c46bf4ed4052a34e3
https://doi.org/10.1021/acs.langmuir.8b03725
https://doi.org/10.1021/acs.langmuir.8b03725
Autor:
Quezia, Lacerda, Ankit, Rochani, Brian, Oeffinger, Ji-Bin, Liu, Corinne E, Wessner, Aylin, Tahmasebi, Hebah, Falatah, Philip, Lee, Dennis B, Leeper, Flemming, Forsberg, Joseph, Curry, Scott W, Keith, Patrick, O'Kane, Gagan, Kaushal, Margaret A, Wheatley, John R, Eisenbrey
Publikováno v:
Int J Pharm
Prior work has shown that microbubble-assisted delivery of oxygen improves tumor oxygenation and radiosensitivity, albeit over a limited duration. Lonidamine (LND) has been investigated because of its ability to stimulate glycolysis, lactate producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730898a6298a784001eb928cfc3d65e0
https://doi.org/10.1016/j.ijpharm.2022.122072
https://doi.org/10.1016/j.ijpharm.2022.122072
Autor:
J.B. Liu, Maria Stanczak, Flemming Forsberg, David Brown, Lauren J Delaney, Masaya Jimbo, Jonathan R. Brody, Brian E. Oeffinger, Margaret A. Wheatley, John R. Eisenbrey
Publikováno v:
Acta Biomater
Ultrasound imaging presents many positive attributes, including safety, real-time imaging, universal accessibility, and cost. However, inherent difficulties in discrimination between soft tissues and tumors prompted development of stabilized microbub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53abb03e814ff82b19a870cd5f062ce9
https://pubmed.ncbi.nlm.nih.gov/34082100
https://pubmed.ncbi.nlm.nih.gov/34082100
Autor:
Patrick O'Kane, Flemming Forsberg, Gagan Kaushal, Margaret A. Wheatley, John R. Eisenbrey, Raj Patel, Brian E. Oeffinger, Quezia Lacerda, Ankit K. Rochani, Dennis B. Leeper
Publikováno v:
2020 IEEE International Ultrasonics Symposium (IUS).
Lonidamine (LND) has been widely explored due to its ability to target metabolic glycolysis and mitochondrial respiration in tumors [4]. However, clinical translation has stalled due to poor bioavailability after oral administration. In this study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::978e8790b6278c362bf09bf6ecaab921
https://doi.org/10.1109/ius46767.2020.9251788
https://doi.org/10.1109/ius46767.2020.9251788
Autor:
Rawan Shraim, John R. Eisenbrey, Brian E. Oeffinger, Lauren J. Jablonowski, Scott W. Keith, Maria Stanczak, Patrick O'Kane, Jingzhi Li, Ji-Bin Liu, Dennis B. Leeper, Margaret A. Wheatley, Flemming Forsberg
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 101:88-96
Much of the volume of solid tumors typically exists in a chronically hypoxic microenvironment that has been shown to result in both chemotherapy and radiation therapy resistance. The purpose of this study was to use localized microbubble delivery to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc993dcc50dbc40ebf6771e5e757e511
https://doi.org/10.1016/j.ijrobp.2018.01.042
https://doi.org/10.1016/j.ijrobp.2018.01.042
Publikováno v:
Journal of Biomedical Materials Research Part A. 106:1903-1915
This study represents the first attempt to combine surface TRAIL expression and doxorubicin co-encapsulation in a single drug delivery agent in the form of ultrasound-responsive microbubbles that shatter into fragments, or nanoshards, in an ultrasoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca37b65b1e8193651c116f411ae169e6
https://doi.org/10.1002/jbm.a.36389
https://doi.org/10.1002/jbm.a.36389