Výsledky vyhledávání - "Margaret A Titus"

Akademický článek

VASP-mediated actin dynamics activate and recruit a filopodia myosin

Autor: Ashley L Arthur, Amy Crawford, Anne Houdusse, Margaret A Titus

Publikováno v: eLife, Vol 10 (2021)

Filopodia are thin, actin-based structures that cells use to interact with their environments. Filopodia initiation requires a suite of conserved proteins but the mechanism remains poorly understood. The actin polymerase VASP and a MyTH-FERM (MF) myo

Externí odkaz: https://doaj.org/article/b8fc969d8cb74e69ae1bd0fcea1eaad6

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Akademický článek

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

Autor: Olena Pylypenko, Tobias Welz, Janine Tittel, Martin Kollmar, Florian Chardon, Gilles Malherbe, Sabine Weiss, Carina Ida Luise Michel, Annette Samol-Wolf, Andreas Till Grasskamp, Alistair Hume, Bruno Goud, Bruno Baron, Patrick England, Margaret A Titus, Petra Schwille, Thomas Weidemann, Anne Houdusse, Eugen Kerkhoff

Publikováno v: eLife, Vol 5 (2016)

There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleato

Externí odkaz: https://doaj.org/article/c2c1af684db44be18ca98b689ff18474

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Akademický článek

The association of myosin IB with actin waves in dictyostelium requires both the plasma membrane-binding site and actin-binding region in the myosin tail.

Autor: Hanna Brzeska, Kevin Pridham, Godefroy Chery, Margaret A Titus, Edward D Korn

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94306 (2014)

F-actin structures and their distribution are important determinants of the dynamic shapes and functions of eukaryotic cells. Actin waves are F-actin formations that move along the ventral cell membrane driven by actin polymerization. Dictyostelium m

Externí odkaz: https://doaj.org/article/728869f7873b41f894ad4d7db486ef3f

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Akademický článek

Myosin 7 and its adaptors link cadherins to actin

Autor: I-Mei Yu, Vicente J. Planelles-Herrero, Yannick Sourigues, Dihia Moussaoui, Helena Sirkia, Carlos Kikuti, David Stroebel, Margaret A. Titus, Anne Houdusse

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin

Externí odkaz: https://doaj.org/article/aa24a24d03664dbc891f02ce9745c6cd

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The many roles of myosins in filopodia, microvilli and stereocilia

Autor: Margaret A. Titus, Anne Houdusse

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2021, 31 (10), pp.R586-R602. ⟨10.1016/j.cub.2021.04.005⟩
Curr Biol

Filopodia, microvilli and stereocilia represent an important group of plasma membrane protrusions. These specialized projections are supported by parallel bundles of actin filaments and have critical roles in sensing the external environment, increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24140e6a6d52125ecaa8477ebe461ee
https://doi.org/10.1016/j.cub.2021.04.005

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Dictyosteliummyosin1Fand myosin1Einhibit actin waves in a lipid‐binding‐dependent and motor‐independent manner

Autor: Michael Bagnoli, Margaret A. Titus, Edward D. Korn, Hanna Brzeska

Publikováno v: Cytoskeleton. 77:295-302

Actin waves are F-actin-rich entities traveling on the ventral plasma membrane by the treadmilling mechanism. Actin waves were first discovered and are best characterized in Dictyostelium. Class I myosins are unconventional monomeric myosins that bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d70ccc3e52c95191eaf3037b98da63c
https://doi.org/10.1002/cm.21627

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Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization ofDictyosteliummyosin 1s

Autor: Jesus Gonzalez, Margaret A. Titus, Edward D. Korn, Hanna Brzeska

Publikováno v: Molecular Biology of the Cell. 31:101-117

Comparison of the highly dynamic localizations of Dictyostelium myosin 1s reveals significant differences between their localizations in macropinocytic protrusions and in actin waves. The short basic-hydrophobic sites lie in conserved positions and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fc8e812287f5e5e0cd61939c87a8e22
https://doi.org/10.1091/mbc.e19-08-0475

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