Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Margaret A Read"'
Autor:
Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90534 (2014)
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several S
Externí odkaz:
https://doaj.org/article/b3435ef7823e4fa0b69c0b4bca9c80e8
Autor:
Amelie A. Hecht, Caroline Glagola Dunn, Eliza W. Kinsey, Margaret A. Read, Ronli Levi, Andrea S. Richardson, Erin R. Hager, Hilary K. Seligman
Publikováno v:
Nutrients, vol 14, iss 7
Nutrients; Volume 14; Issue 7; Pages: 1387
Nutrients; Volume 14; Issue 7; Pages: 1387
The COVID-19 pandemic resulted in widespread school closures, reducing access to school meals for millions of students previously participating in the US Department of Agriculture (USDA) National School Lunch Program (NSLP). School-prepared meals are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef521081b84c5408ce059b7d23e8ba15
https://escholarship.org/uc/item/8m13k85f
https://escholarship.org/uc/item/8m13k85f
Autor:
Joi Dunbar, Margaret A. Read, Joseph D. Manna, Alexander Constan, Alfredo C. Castro, Sherri Smith, Gordon Loewen, John Lee, Somarajan J. Nair, Jennifer Hoyt, Martin R. Tremblay, Julian Adams, Jeanne A. Ferguson, Jens Sydor, Veronica Campbell, Matthew Campbell, Karen McGovern, Brendan Arsenault, Marisa O. Peluso, Jylle Nevejans, Vito J. Palombella, Nigel Whitebread, Grogan Michael John, Kerrie Faia, John Soglia, Bennett Carter
Publikováno v:
Xenobiotica. 43:875-885
1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926 is low in mouse and dog and moderate in monkey. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50620a2c18fbef25785c49cf6a0c9deb
https://doi.org/10.3109/00498254.2013.780671
https://doi.org/10.3109/00498254.2013.780671
Autor:
Matthew Campbell, Caroline N. Woodward, Jens Sydor, Alfredo C. Castro, James R. Porter, Margaret A. Read, Kerrie Faia, Kerry White, Martin R. Tremblay, Jill Cushing, Julian Adams, Lin-Chen Yu, Mark L. Behnke, Jennifer Hoyt, Vito J. Palombella, Karen McGovern, Somarajan J. Nair, Jeffrey K. Tong, Margit Hagel, Marta Nevalainen, Louis Grenier, Michael Foley
Publikováno v:
Journal of Medicinal Chemistry. 51:6646-6649
Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d0752adc424ed0f2bb4f871b70a4f4
https://doi.org/10.1021/jm8008508
https://doi.org/10.1021/jm8008508
Autor:
Vito J. Palombella, Tatiana B. Gladysheva, Jacqueline W. Pierce, Lana A. Parent, Michael B. Coggins, Vincent Chau, Maria Hottelet, Rong Shu Luo, Vladimir N. Podust, James E. Brownell, Margaret A. Read
Publikováno v:
Molecular and Cellular Biology. 20:2326-2333
NF-κB is a transcription factor required for inducible expression of a number of proinflammatory mediators including cytokines, chemokines, and leukocyte adhesion molecules (6). In addition, NF-κB regulates the expression of survival genes which pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::888b283bd450c907ea58d35926f11e86
https://doi.org/10.1128/mcb.20.7.2326-2333.2000
https://doi.org/10.1128/mcb.20.7.2326-2333.2000
Autor:
James M. Conley, Karen McGovern, Jeffery L. Kutok, Kerry White, Kerrie Faia, Margaret A. Read, Marisa O. Peluso, Joseph A. Harari, Nigel Whitebread, Thomas T. Tibbitts, Veronica Campbell, Jennifer Proctor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 3, p e90534 (2014)
PLoS ONE, Vol 9, Iss 3, p e90534 (2014)
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ec2bdc0b8d0bdc70a4aa0ddb587842
https://pubmed.ncbi.nlm.nih.gov/24608250
https://pubmed.ncbi.nlm.nih.gov/24608250
Autor:
Margaret A. Read, O. P. Veiby
Publikováno v:
Clinical Cancer Research. 10:3262-3264
Resistance of cancer cells to powerful chemotherapeutic drugs has been an area of intense investigation. Efforts to understand the mechanisms underlying chemoresistance have led to significant progress toward our understanding of signaling pathways t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e832c2b30b00e591cd636cac33f0ae3
https://doi.org/10.1158/1078-0432.ccr-04-0703
https://doi.org/10.1158/1078-0432.ccr-04-0703
Publikováno v:
Molecular and Cellular Biology. 15:2558-2569
Transcription of the vascular cell adhesion molecule 1 (VCAM-1) gene in endothelial cells is induced by lipopolysaccharide and the inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha (TNF-alpha). Previous studies have demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b103671abcda4dab67fbc8b8d08641c
https://doi.org/10.1128/mcb.15.5.2558
https://doi.org/10.1128/mcb.15.5.2558
Publikováno v:
Molecular and Cellular Biology. 14:6464-6475
Transcription of the endothelial leukocyte adhesion molecule 1 (E-selectin or ELAM-1) gene is induced by the inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha (TNF-alpha). In this report, we identify four positive regulatory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27de24d0158c22097531101ae8dddb9e
https://doi.org/10.1128/mcb.14.10.6464
https://doi.org/10.1128/mcb.14.10.6464
Publikováno v:
The Journal of Experimental Medicine
Structural analysis of the promoters of several endothelial genes induced at sites of inflammatory or immune responses reveals binding sites for the transcription factor nuclear factor kappa B (NF-kappa B). Endothelial cells express transcripts encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a29e5487e20b8912f0cd980a3ef8e34
https://doi.org/10.1084/jem.179.2.503
https://doi.org/10.1084/jem.179.2.503