Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Margaret A Goodell"'
Autor:
Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Uryu, Ayala Tovy, Elsa Callen, Rebecca L Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert BA de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie Anastas, Koichi Takahashi, George Vassiliou, Margaret A Goodell
Publikováno v:
eLife, Vol 12 (2024)
The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase Mg2+/Mn2+-dependent 1D) is a master negative regulator of the response; gain-of-function mutations
Externí odkaz:
https://doaj.org/article/8b2d747c20e044a49c29f804096153ef
Autor:
Ayala Tovy, Jaime M Reyes, Linda Zhang, Yung-Hsin Huang, Carina Rosas, Alexes C Daquinag, Anna Guzman, Raghav Ramabadran, Chun-Wei Chen, Tianpeng Gu, Sinjini Gupta, Laura Ortinau, Dongsu Park, Aaron R Cox, Rachel E Rau, Sean M Hartig, Mikhail G Kolonin, Margaret A Goodell
Publikováno v:
eLife, Vol 11 (2022)
DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity and exce
Externí odkaz:
https://doaj.org/article/50aa572dd7974a318da9ef564b060f60
Autor:
Chongyuan Luo, Qian Yi Lee, Orly Wapinski, Rosa Castanon, Joseph R Nery, Moritz Mall, Michael S Kareta, Sean M Cullen, Margaret A Goodell, Howard Y Chang, Marius Wernig, Joseph R Ecker
Publikováno v:
eLife, Vol 8 (2019)
Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-r
Externí odkaz:
https://doaj.org/article/9ddb88e6e2a54fc28cfcbc1f3cab0113
Autor:
Juliette J Kahle, George P Souroullas, Peng Yu, Fabian Zohren, Yoontae Lee, Chad A Shaw, Huda Y Zoghbi, Margaret A Goodell
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003359 (2013)
Hematopoietic stem cells (HSCs) are rare quiescent cells that continuously replenish the cellular components of the peripheral blood. Observing that the ataxia-associated gene Ataxin-1-like (Atxn1L) was highly expressed in HSCs, we examined its role
Externí odkaz:
https://doaj.org/article/29ae8d66add846f0880c2c6451b2ae28
Autor:
R Alan Harris, Chad Shaw, Jian Li, Sau Wai Cheung, Cristian Coarfa, Mira Jeong, Margaret A Goodell, Lisa D White, Ankita Patel, Sung-Hae Kang, A Craig Chinault, Tomasz Gambin, Anna Gambin, James R Lupski, Aleksandar Milosavljevic
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003333 (2013)
Externí odkaz:
https://doaj.org/article/42f726a25e3e4645aad46ac1766b7ca7
Autor:
Jian Li, R Alan Harris, Sau Wai Cheung, Cristian Coarfa, Mira Jeong, Margaret A Goodell, Lisa D White, Ankita Patel, Sung-Hae Kang, Chad Shaw, A Craig Chinault, Tomasz Gambin, Anna Gambin, James R Lupski, Aleksandar Milosavljevic
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002692 (2012)
The hotspots of structural polymorphisms and structural mutability in the human genome remain to be explained mechanistically. We examine associations of structural mutability with germline DNA methylation and with non-allelic homologous recombinatio
Externí odkaz:
https://doaj.org/article/41f8edd87ece4f28b8c093a59f15c7fa
Autor:
Kuanyin K Lin, Lara Rossi, Nathan C Boles, Brian E Hall, Thaddeus C George, Margaret A Goodell
Publikováno v:
PLoS Biology, Vol 9, Iss 9, p e1001148 (2011)
The regulatory mechanisms governing the cell cycle progression of hematopoietic stem cells (HSCs) are well characterized, but those responsible for the return of proliferating HSCs to a quiescent state remain largely unknown. Here, we present evidenc
Externí odkaz:
https://doaj.org/article/f7fd64cce3fa4f97bac214d24dce9323
Autor:
Jonathan S Berg, Kuanyin K Lin, Corinne Sonnet, Nathan C Boles, David C Weksberg, Hoang Nguyen, Lowenna J Holt, Danny Rickwood, Roger J Daly, Margaret A Goodell
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26410 (2011)
Lifelong, many somatic tissues are replenished by specialized adult stem cells. These stem cells are generally rare, infrequently dividing, occupy a unique niche, and can rapidly respond to injury to maintain a steady tissue size. Despite these commo
Externí odkaz:
https://doaj.org/article/5fcd01c25edc41dd99bfa5960a25267d
Autor:
Katherine Y King, Justin D Lew, Ngan P Ha, Jeffery S Lin, Xin Ma, Edward A Graviss, Margaret A Goodell
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16317 (2011)
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic
Externí odkaz:
https://doaj.org/article/ca24403e510c4936a9f9beb853f4badf
Autor:
Georgi L Lukov, Margaret A Goodell
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
The Lymphoblastic leukemia 1 (LYL1) gene is a proto-oncogenic transcription factor found upregulated in patients with T-cell acute lymphoblastic leukemia (T-cell ALL). Initially, the upregulation was described to be as a result of a translocation. Ho
Externí odkaz:
https://doaj.org/article/e7c78c85aaa3460e9f148c55eedbb682