Zobrazeno 1 - 10
of 956
pro vyhledávání: '"Margaret A Brimble"'
Autor:
Olivia K Burn, Kathryn Farrand, Tara Pritchard, Sarah Draper, Ching‐wen Tang, Anna H Mooney, Alfonso J Schmidt, Sung H Yang, Geoffrey M Williams, Margaret A Brimble, Matheswaran Kandasamy, Andrew J Marshall, Kate Clarke, Gavin F Painter, Ian F Hermans, Robert Weinkove
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 7, Pp n/a-n/a (2022)
Abstract Objectives Metastasis is the principal cause of breast cancer mortality. Vaccines targeting breast cancer antigens have yet to demonstrate clinical efficacy, and there remains an unmet need for safe and effective treatment to reduce the risk
Externí odkaz:
https://doaj.org/article/3c9b77a20a6e4b3da7b8452985eb9f84
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99135 (2014)
The pili expressed on the surface of the human pathogen Streptococcus pyogenes play an important role in host cell attachment, colonisation and pathogenesis. These pili are built from two or three components, an adhesin subunit at the tip, a major pi
Externí odkaz:
https://doaj.org/article/a05f463c055749cf9e8de738ac8c99da
Publikováno v:
ARKIVOC, Vol 2001, Iss 7, Pp 37-48 (2001)
Externí odkaz:
https://doaj.org/article/0e7b0c2cff8c4c89a7fe04fce5b18fe2
Publikováno v:
Antibiotics, Vol 13, Iss 7, p 615 (2024)
Capitellacin (1) is a 20-residue antimicrobial β-hairpin, produced by the marine polychaeta (segmented worms) Capitella teletai. Since its discovery in 2020, only very limited studies have been undertaken to understand capitellacin’s structure–a
Externí odkaz:
https://doaj.org/article/1c77f25f49b84955a3063602cb7d298c
Publikováno v:
Cells, Vol 13, Iss 9, p 788 (2024)
Norbormide (NRB) is a Rattus-selective toxicant, which was serendipitously discovered in 1964 and formerly marketed as an eco-friendly rodenticide that was deemed harmless to non-Rattus species. However, due to inconsistent efficacy and the emergence
Externí odkaz:
https://doaj.org/article/2b3f345730c942bf805c26147ebad733
Autor:
Bin Lin, Smitha Nair, Daniel M. J. Fellner, Noha Ahmed Nasef, Harjinder Singh, Leonardo Negron, David C. Goldstone, Margaret A. Brimble, Juliet A. Gerrard, Laura Domigan, Jackie C. Evans, Jonathan M. Stephens, Troy L. Merry, Kerry M. Loomes
Publikováno v:
Foods, Vol 12, Iss 22, p 4072 (2023)
3,6,7-trimethyllumazine (Lepteridine™) is a newly discovered natural pteridine derivative unique to Mānuka (Leptospermum scoparium) nectar and honey, with no previously reported biological activity. Pteridine derivative-based medicines, such as me
Externí odkaz:
https://doaj.org/article/7474211470de49f6811314d0746139e9
Autor:
Alice-Roza Eruera, Alice M. McSweeney, Geena M. McKenzie-Goldsmith, Helen K. Opel-Reading, Simone X. Thomas, Ashley C. Campbell, Louise Stubbing, Andrew Siow, Jonathan G. Hubert, Margaret A. Brimble, Vernon K. Ward, Kurt L. Krause
Publikováno v:
Viruses, Vol 15, Iss 11, p 2202 (2023)
Norovirus is the leading cause of viral gastroenteritis worldwide, and there are no approved vaccines or therapeutic treatments for chronic or severe norovirus infections. The structural characterisation of the norovirus protease and drug development
Externí odkaz:
https://doaj.org/article/86ca3c78c4f045989589594a543e6b57
Autor:
Shama Dissanayake, Junming He, Sung H. Yang, Margaret A. Brimble, Paul W. R. Harris, Alan J. Cameron
Publikováno v:
Molecules, Vol 28, Iss 4, p 1993 (2023)
Antimicrobial peptides (AMPs) hold promise as novel therapeutics in the fight against multi-drug-resistant pathogens. Cathelicidin-PY (NH2-RKCNFLCKLKEKLRTVITSHIDKVLRPQG-COOH) is a 29-residue disulfide-cyclised antimicrobial peptide secreted as an inn
Externí odkaz:
https://doaj.org/article/835b95e6798547208ebdf6c37d347946
Autor:
Johanes K. Kasim, Jiwon Hong, Anthony J. R. Hickey, Anthony R. J. Phillips, John A. Windsor, Paul W. R. Harris, Margaret A. Brimble, Iman Kavianinia
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 287 (2023)
Pancreatic ductal adenocarcinoma remains a highly debilitating condition with no effective disease-modifying interventions. In our search for natural products with promising anticancer activity, we identified the aminolipopeptide trichoderin A as a p
Externí odkaz:
https://doaj.org/article/4a4bf5fdacd7466e878c6d5f128b7748
Autor:
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Simon J. O’Carroll, Debbie L. Hay, Christopher S. Walker
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13797 (2022)
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide expressed in the trigeminal ganglia (TG). The TG conducts nociceptive signals in the head and may play roles in migraine. PACAP infusion provokes headaches in healthy individual
Externí odkaz:
https://doaj.org/article/3c985c4848b547de8c5767f2450c441c