Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Margaret A, Phillips"'
Autor:
Leah S. Imlay, Aloysus K. Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno Crespo-Fernandez, Bruce A. Posner, Francisco-Javier Gamo, Jake Baum, Elizabeth A. Winzeler, Benoît Laleu, Joseph M. Ready, Margaret A. Phillips
Publikováno v:
ACS Infectious Diseases. 9:527-539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537f1ef2dacdeb367b99fd7da88c7d0b
https://doi.org/10.1021/acsinfecdis.2c00527
https://doi.org/10.1021/acsinfecdis.2c00527
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 10, Iss , Pp 84-86 (2018)
Purpose: To describe a case of orbital apex syndrome as a result of isolated bacterial sinusitis. Observations: A 63-year-old woman presented with an orbital apex syndrome from isolated bacterial sinusitis with rapidly declining visual acuity to no l
Externí odkaz:
https://doaj.org/article/c277d533f483467da20c613245685fa9
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 7, Iss 10, p e2464 (2019)
Summary:. The purpose of this article is to present a modified approach to the reconstruction of the upper and lower eyelids in floppy eyelid syndrome. A retrospective chart review was performed on all floppy eyelid patients who underwent simultaneou
Externí odkaz:
https://doaj.org/article/97496e44824441d886858a67ca306908
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Viruses produce more viruses by manipulating the metabolic and replication systems of their host cells. Many have acquired metabolic genes from ancestral hosts and use the encoded enzymes to subvert host metabolism. The polyamine spermidine is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85a24bd8b5b3a55573d2b6172fd6abb7
https://doi.org/10.1073/pnas.2214165120
https://doi.org/10.1073/pnas.2214165120
Autor:
Thomas A. Russo, Timothy C. Umland, Xiaoyi Deng, Farah El Mazouni, Sreekanth Kokkonda, Ruth Olson, Ulrike Carlino-MacDonald, Janet Beanan, Cassandra L. Alvarado, Diana R. Tomchick, Alan Hutson, Hong Chen, Bruce Posner, Pradipsinh K. Rathod, Susan A. Charman, Margaret A. Phillips
Publikováno v:
Proceedings of the National Academy of Sciences. 119
New antimicrobials are needed for the treatment of extensively drug-resistant Acinetobacter baumannii . The de novo pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated drug target for malaria and human autoimmune diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc6ec53ccd9e36bdbbf8dceef4e67d0
https://doi.org/10.1073/pnas.2213116119
https://doi.org/10.1073/pnas.2213116119
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007404 (2018)
Polyamines are essential for cell growth of eukaryotes including the etiologic agent of human African trypanosomiasis (HAT), Trypanosoma brucei. In trypanosomatids, a key enzyme in the polyamine biosynthetic pathway, S-adenosylmethionine decarboxylas
Externí odkaz:
https://doaj.org/article/0c24b5f851014cc9a43c55c7991a1fe3
Autor:
Margaret D. Phillips, Daniel E. Anderson, Jane C. Nelson, Hamilton T. Evans, Sarah E. Dutton, AnGayle K. Vasiliou
Publikováno v:
ACS Symposium Series ISBN: 9780841297432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f12af343e93ad4333fb66d1590a18cc
https://doi.org/10.1021/bk-2022-1428.ch006
https://doi.org/10.1021/bk-2022-1428.ch006
Autor:
Leah S. Imlay, Aloysus K. Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno Crespo-Fernandez, Bruce Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A. Winzeler, Benoît Laleu, Joseph M. Ready, Margaret A. Phillips
Current malaria treatments are threatened by drug resistance and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with asexual blood and liver stage activity and a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e075d7b4525241704c6d99d7df97273
https://doi.org/10.1101/2022.10.16.512381
https://doi.org/10.1101/2022.10.16.512381
Autor:
Oleg A Volkov, Lisa Kinch, Carson Ariagno, Xiaoyi Deng, Shihua Zhong, Nick Grishin, Diana R Tomchick, Zhe Chen, Margaret A Phillips
Publikováno v:
eLife, Vol 5 (2016)
Catalytically inactive enzyme paralogs occur in many genomes. Some regulate their active counterparts but the structural principles of this regulation remain largely unknown. We report X-ray structures of Trypanosoma brucei S-adenosylmethionine decar
Externí odkaz:
https://doaj.org/article/8fb0a907483d4638b5df7535ddd67675
Autor:
Sergio Wittlin, Sachel Mok, Benoît Laleu, Anwu Zhou, Susan A. Charman, Margaret A. Phillips, Tomas Yeo, David A. Fidock, Alisje Churchyard, Joseph M. Ready, Francisco-Javier Gamo, Ioanna Deni, John Okombo, Bruce A. Posner, Aloysus K. Lawong, Jessica L. Bridgford, Elizabeth A. Winzeler, Benigno Crespo, Michael J. Palmer, Hanspeter Niederstrasser, Josefine Striepen, Suraksha Gahalawat, Jake Baum, Nimisha Mittal
Publikováno v:
Journal of Medicinal Chemistry. 64:2739-2761
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c2c4959d61f50243834064afd89e585
https://doi.org/10.1021/acs.jmedchem.0c02022
https://doi.org/10.1021/acs.jmedchem.0c02022