Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Margaret A, Knowles"'
Autor:
Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)
Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing
Externí odkaz:
https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6
Autor:
Joshua I. Warrick, Margaret A. Knowles, Carolyn D. Hurst, Lauren Shuman, Jay D. Raman, Vonn Walter, Jeffrey Putt, Lars Dyrskjøt, Clarice Groeneveld, Mauro A. A. Castro, A. Gordon Robertson, David J. DeGraff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Human cancers display a restricted set of expression profiles, despite diverse mutational drivers. This has led to the hypothesis that select sets of transcription factors act on similar target genes as an integrated network, buffering a tum
Externí odkaz:
https://doaj.org/article/5d6653d9f5dd4dd3b7afe6712bdf88da
Autor:
Carolyn D Hurst, Guo Cheng, Fiona M Platt, Olivia Alder, Emma VI Black, Julie E Burns, Joanne Brown, Sunjay Jain, Jo‐An Roulson, Margaret A Knowles
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 3, Pp 279-293 (2022)
Abstract Pure squamous cell carcinoma (SCC) is the most common pure variant form of bladder cancer, found in 2–5% of cases. It often presents late and is unresponsive to cisplatin‐based chemotherapy. The molecular features of these tumours have n
Externí odkaz:
https://doaj.org/article/37062d89cb4f4c22859e462534494f59
Autor:
Sia Viborg Lindskrog, Frederik Prip, Philippe Lamy, Ann Taber, Clarice S. Groeneveld, Karin Birkenkamp-Demtröder, Jørgen Bjerggaard Jensen, Trine Strandgaard, Iver Nordentoft, Emil Christensen, Mateo Sokac, Nicolai J. Birkbak, Lasse Maretty, Gregers G. Hermann, Astrid C. Petersen, Veronika Weyerer, Marc-Oliver Grimm, Marcus Horstmann, Gottfrid Sjödahl, Mattias Höglund, Torben Steiniche, Karin Mogensen, Aurélien de Reyniès, Roman Nawroth, Brian Jordan, Xiaoqi Lin, Dejan Dragicevic, Douglas G. Ward, Anshita Goel, Carolyn D. Hurst, Jay D. Raman, Joshua I. Warrick, Ulrika Segersten, Danijel Sikic, Kim E. M. van Kessel, Tobias Maurer, Joshua J. Meeks, David J. DeGraff, Richard T. Bryan, Margaret A. Knowles, Tatjana Simic, Arndt Hartmann, Ellen C. Zwarthoff, Per-Uno Malmström, Núria Malats, Francisco X. Real, Lars Dyrskjøt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated
Externí odkaz:
https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d
Autor:
Delanyo Kpeglo, Matthew D.G. Hughes, Lorna Dougan, Malcolm Haddrick, Margaret A. Knowles, Stephen D. Evans, Sally A. Peyman
Publikováno v:
Matrix Biology Plus, Vol 14, Iss , Pp 100109- (2022)
Despite improvements in the understanding of disease biology, pancreatic ductal adenocarcinoma (PDAC) remains the most malignant cancer of the pancreas. PDAC constitutes ∼95% of all pancreatic cancers, and it is highly resistant to therapeutics. Th
Externí odkaz:
https://doaj.org/article/1fac1be2a17a44cbbc18649805505c61
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Activating mutations of fibroblast growth factor receptor 3 (FGFR3) are common in urothelial carcinoma of the bladder (UC). Silencing or inhibition of mutant FGFR3 in bladder cancer cell lines is associated with decreased malignant potential
Externí odkaz:
https://doaj.org/article/7bb60571b5e24f2aa7be8f839790e504
Autor:
Paul Mellor, Jeremy D. S. Marshall, Xuan Ruan, Dielle E. Whitecross, Rebecca L. Ross, Margaret A. Knowles, Stanley A. Moore, Deborah H. Anderson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations
Externí odkaz:
https://doaj.org/article/623db4a84b7e4de981307ebca5478389
Autor:
Geoffrey A Pettitt, Carolyn D Hurst, Zubeda Khan, Helen R McPherson, Matthew C Dunning, Olivia Alder, Fiona M Platt, Emma VI Black, Julie E Burns, Margaret A Knowles
Publikováno v:
The Journal of Pathology. 259:220-232
Alterations of fibroblast growth factor receptors (FGFRs) are common in bladder and other cancers and result in disrupted signalling via several pathways. Therapeutics that target FGFRs have now entered the clinic, but in common with many cancer ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3c8413f678b31e2f287b30e95dbab9
https://doi.org/10.1002/path.6034
https://doi.org/10.1002/path.6034
Autor:
Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the dow
Externí odkaz:
https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
Autor:
Nour-Al-Dain Marzouka, Pontus Eriksson, Carina Bernardo, Carolyn D. Hurst, Margaret A. Knowles, Gottfrid Sjödahl, Fredrik Liedberg, Mattias Höglund
Publikováno v:
The Journal of Molecular Diagnostics. 24:992-1008
The precise classification of tumors into relevant molecular subtypes will facilitate both future research and optimal treatment. Here, the Lund Taxonomy system for molecular classification of urothelial carcinoma was applied to two large and indepen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96390ba4c2c296468c1a7aff6716f188
https://doi.org/10.1016/j.jmoldx.2022.05.006
https://doi.org/10.1016/j.jmoldx.2022.05.006