Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Margaret A, Holmes"'
Autor:
Kathryn A K Finton, Della Friend, James Jaffe, Mesfin Gewe, Margaret A Holmes, H Benjamin Larman, Andrew Stuart, Kevin Larimore, Philip D Greenberg, Stephen J Elledge, Leonidas Stamatatos, Roland K Strong
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004403 (2014)
The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the conformer optimal for binding from the broader ensemble accessible to the precursor. However
Externí odkaz:
https://doaj.org/article/45f3e83ef2314dde8d33dae1238ab588
Autor:
Colin Correnti, Vera Richardson, Allyson K Sia, Ashok D Bandaranayake, Mario Ruiz, Yohan Suryo Rahmanto, Žaklina Kovačević, Matthew C Clifton, Margaret A Holmes, Brett K Kaiser, Jonathan Barasch, Kenneth N Raymond, Des R Richardson, Roland K Strong
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43696 (2012)
Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators. In innate immunity, siderocalin slows the growth of infecting bacteria by sequestering bac
Externí odkaz:
https://doaj.org/article/0c7a60a30b9141c7948d0f013f4ece1f
Autor:
Colin Correnti, Bruno E. Correia, Barney S. Graham, Philip R. Johnson, Rachel E. Klevit, Andreia M. Serra, John T. Bates, Vinayak Vittal, Gretchen Baneyx, Yumiko Adachi, David Baker, Oleksandr Kalyuzhniy, Man Chen, William R. Schief, Alexandria Schroeter, Skye MacPherson, Mary J. Connell, James E. Crowe, Joseph G. Jardine, Rebecca J. Loomis, Roland K. Strong, Peter B. Rupert, Eric Stevens, Chris Carrico, Richard T. Wyatt, Yuxing Li, Margaret A. Holmes
Publikováno v:
Nature
Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892dd704d49c9adc2677e4ec3572a392
https://doi.org/10.1038/nature12966
https://doi.org/10.1038/nature12966
Publikováno v:
Pathology Case Reviews. 19:269-275
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::631563ed1e63e4faf235e9cf62ac0cd6
https://doi.org/10.1097/pcr.0000000000000052
https://doi.org/10.1097/pcr.0000000000000052
Autor:
William C. Crall, Matthew P. Alexander, Malcolm J. Lippert, Kaitlyn J. Begins, Margaret P. Holmes
Publikováno v:
Environmental and Molecular Mutagenesis. 54:44-53
High-levels of transcription through a gene stimulate spontaneous mutation rate, a phenomenon termed transcription-associated mutation (TAM). While transcriptional effects on specific mutation classes have been identified using forward mutation and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae71a28e0a8b8f9316f2966f53d3698
https://doi.org/10.1002/em.21740
https://doi.org/10.1002/em.21740
Autor:
Helen Neely, Wim G. J. Hol, Angela Lauricella, Margaret A. Holmes, Ethan A. Merritt, Frederick S. Buckner, Joseph R. Luft, Frank Zucker, Erin Quartly, Eric M. Phizicky, Wesley C. Van Voorhis, George T. DeTitta
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 64:474-478
The structure of a structural genomics target protein, Tbru020260AAA from Trypanosoma brucei, has been determined to a resolution of 2.2 A using multiple-wavelength anomalous diffraction at the Se K edge. This protein belongs to Pfam sequence family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c06a9afe4809b3fc64517cc0c64bae
https://doi.org/10.1107/s174430910801141x
https://doi.org/10.1107/s174430910801141x
Autor:
Joseph R. Luft, Wim G. J. Hol, Oleksandr Kalyuzhniy, Wesley C. Van Voorhis, Christopher Mehlin, Erica Boni, Frank Zucker, Thomas Earnest, Lori Anderson, Frederick S. Buckner, Christophe L. M. J. Verlinde, Margaret A. Holmes, Ethan A. Merritt, Lori W. Schoenfeld, George T. DeTitta, Angela Lauricella
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 62:427-431
The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 angstroms resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c41e8353b38f0c44584863e9eae872
https://doi.org/10.1107/s1744309106010876
https://doi.org/10.1107/s1744309106010876
Autor:
Elizabeth A. Worthey, Frederick S. Buckner, Stacey Gulde, Peter J. Myler, M. Soltis, Joseph R. Luft, Jonathan M. Caruthers, Erica Boni, Wes Van Voorhuis, Margaret A. Holmes, Tiffany Feist, Isolde Le Trong, Lori Anderson, Keith O. Hodgson, Thomas Earnest, Wim G. J. Hol, Ethan A. Merritt, Frank H. Zucker, Christopher Mehlin, Angela M. Lauricella, Oleksandr Kaluzhniy
Publikováno v:
Protein Science. 14:2887-2894
We have determined the crystal structures of three homologous proteins from the pathogenic protozoans Leishmania donovani, Leishmania major, and Trypanosoma cruzi. We propose that these proteins represent a new subfamily within the isochorismatase su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e8975628a0c958dd8f69c8f0e9c81d1
https://doi.org/10.1110/ps.051783005
https://doi.org/10.1110/ps.051783005
Publikováno v:
Structure. 13:29-41
SummarySiderocalin, a member of the lipocalin family of binding proteins, is found in neutrophil granules, uterine secretions, and at markedly elevated levels in serum and synovium during bacterial infection; it is also secreted from epithelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18118b41c566f1f75d809688ca5fbd34
https://doi.org/10.1016/j.str.2004.10.009
https://doi.org/10.1016/j.str.2004.10.009