Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner

Autor: Natasja Barki, Laura Jenkins, Sara Marsango, Domonkos Dedeo, Daniele Bolognini, Louis Dwomoh, Aisha M Abdelmalik, Margaret Nilsen, Manon Stoffels, Falko Nagel, Stefan Schulz, Andrew B Tobin, Graeme Milligan

Publikováno v: eLife, Vol 12 (2023)

Free fatty acid receptor 2 (FFAR2) is activated by short-chain fatty acids and expressed widely, including in white adipocytes and various immune and enteroendocrine cells. Using both wild-type human FFAR2 and a designer receptor exclusively activate

Externí odkaz: https://doaj.org/article/9b6b31128d5a4d21aaccb0f61f49509e

Understanding longitudinal biventricular structural and functional changes in a pulmonary hypertension Sugen–hypoxia rat model by cardiac magnetic resonance imaging

Autor: Geeshath Jayasekera, Kathryn S. Wilson, Hanna Buist, Rosemary Woodward, Aysel Uckan, Colin Hughes, Margaret Nilsen, A Colin Church, Martin K. Johnson, Lindsay Gallagher, James Mullin, Mandy R. MacLean, William M. Holmes, Andrew J. Peacock, David J. Welsh

Publikováno v: Pulmonary Circulation, Vol 10 (2020)

Cardiac magnetic resonance-derived ventricular variables are predictive of mortality in pulmonary arterial hypertension. Rodent models which emphasize ventricular function, allowing serial monitoring, are needed to identify pathophysiological feature

Externí odkaz: https://doaj.org/article/16df05497cb345c3b63ec397451bbf19

Sex-Dependent Changes in Right Ventricular Gene Expression in Response to Pressure Overload in a Rat Model of Pulmonary Trunk Banding

Autor: Hicham Labazi, Julie Birkmose Axelsen, Dianne Hillyard, Margaret Nilsen, Asger Andersen, Margaret R. MacLean

Publikováno v: Biomedicines, Vol 8, Iss 10, p 430 (2020)

Right ventricular hypertrophy (RVH) and subsequent failure are consequences of pulmonary arterial hypertension (PAH). While females are four times more likely to develop PAH, male patients have poorer survival even with treatment, suggesting a sex-de

Externí odkaz: https://doaj.org/article/6313fc8e6072443795423e6217b085e6

Sex-dependent right ventricular hypertrophic gene changes after methamphetamine treatment in mice

Autor: Hicham Labazi, Margaret R. MacLean, Margaret Nilsen

Publikováno v: European Journal of Pharmacology

Methamphetamine (MA) abuse is associated with the development of pulmonary arterial hypertension (PAH) and subsequent right ventricular failure. A recent clinical study demonstrated that female sex is a major risk factor for MA-induced PAH. The mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ccd1094f1f87a359018e8f8d44a225
http://europepmc.org/articles/PMC8111419

Sex-dependent changes in right ventricular gene expression in response to pressure overload in a rat model of pulmonary trunk banding

Autor: Margaret Nilsen, Hicham Labazi, Julie Birkmose Axelsen, Dianne Z. Hillyard, Margaret R. MacLean, Asger Andersen

Publikováno v: Biomedicines, Vol 8, Iss 430, p 430 (2020)
Biomedicines
Volume 8
Issue 10
Labazi, H, Axelsen, J B, Hillyard, D, Nilsen, M, Andersen, A & Maclean, M R 2020, ' Sex-dependent changes in right ventricular gene expression in response to pressure overload in a rat model of pulmonary trunk banding ', Biomedicines, vol. 8, no. 10, 430 . https://doi.org/10.3390/biomedicines8100430

Right ventricular hypertrophy (RVH) and subsequent failure are consequences of pulmonary arterial hypertension (PAH). While females are four times more likely to develop PAH, male patients have poorer survival even with treatment, suggesting a sex-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfe0129e45c156fa96586e3a2575834
https://eprints.gla.ac.uk/228278/1/228278.pdf