New insights from genetic studies of eczema

Autor: Marenholz, I., Arnau-Soler, A., Rosillo-Salazar, O.D., Lee, Y.A.

Genome-wide association studies (GWAS) provided fundamental insight into the genetic determinants of complex allergic diseases. For eczema, 58 susceptibility loci were reported. Protein-changing variants were associated with eczema at genome-wide sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::6877d1b43283833218f50177b8d1ef71
http://edoc.mdc-berlin.de/23271/1/23271oa.pdf

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

Autor: Grosche, S. (Sarah), Marenholz, I. (Ingo), Esparza-Gordillo, J. (Jorge), Arnau-Soler, A. (Aleix), Pairo-Castineira, E. (Erola), Rueschendorf, F. (Franz), Ahluwalia, T. S. (Tarunveer S.), Almqvist, C. (Catarina), Arnold, A. (Andreas), Baurecht, H. (Hansjoerg), Bisgaard, H. (Hans), Bonnelykke, K. (Klaus), Brown, S. J. (Sara J.), Bustamante, M. (Mariona), Curtin, J. A. (John A.), Custovic, A. (Adnan), Dharmage, S. C. (Shyamali C.), Esplugues, A. (Ana), Falchi, M. (Mario), Fernandez-Orth, D. (Dietmar), Ferreira, M. A. (Manuel A. R.), Franke, A. (Andre), Gerdes, S. (Sascha), Gieger, C. (Christian), Hakonarson, H. (Hakon), Holt, P. G. (Patrick G.), Homuth, G. (Georg), Hubner, N. (Norbert), Hysi, P. G. (Pirro G.), Järvelin, M.-R. (Marjo-Riitta), Karlsson, R. (Robert), Koppelman, G. H. (Gerard H.), Lau, S. (Susanne), Lutz, M. (Manuel), Magnusson, P. K. (Patrik K. E.), Marks, G. B. (Guy B.), Mueller-Nurasyid, M. (Martina), Noethen, M. M. (Markus M.), Paternoster, L. (Lavinia), Pennell, C. E. (Craig E.), Peters, A. (Annette), Rawlik, K. (Konrad), Robertson, C. F. (Colin F.), Rodriguez, E. (Elke), Sebert, S. (Sylvain), Simpson, A. (Angela), Sleiman, P. M. (Patrick M. A.), Standl, M. (Marie), Stoelzl, D. (Dora), Strauch, K. (Konstantin), Szwajda, A. (Agnieszka), Tenesa, A. (Albert), Thompson, P. J. (Philip J.), Ullemar, V. (Vilhelmina), Visconti, A. (Alessia), Vonk, J. M. (Judith M.), Wang, C. A. (Carol A.), Weidinger, S. (Stephan), Wielscher, M. (Matthias), Worth, C. L. (Catherine L.), Xu, C.-J. (Chen-Jian), Lee, Y.-A. (Young-Ae)

Publikováno v: Nature Communications
Nature Communications, 12:6618. Nature Publishing Group
Nat. Commun. 12:6618 (2021)

Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cd59cbf3a46c2a61abe8049da55a1202
https://pubmed.ncbi.nlm.nih.gov/34785669

Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy

Autor: Marenholz, I., Grosche, S., Kalb, B., Rüschendorf, F., Blümchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Röblitz, H., Yürek, S., Tschirner, S., Hong, X., Wang, X., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hübner, N., Niggemann, B., Beyer, K., Lee, Y.A.

Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food chall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::db37ff9c9f3e6e5534ab76468cad939b
http://edoc.mdc-berlin.de/16872/7/16872suppl.zip

Genetik des atopischen Ekzems.

Autor: Marenholz, I.¹, Lee, Y.A.¹ yolee@mdc-berlin.de

Publikováno v: Medizinische Genetik. Dec2009, Vol. 21 Issue 4, p493-497. 5p.

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

Autor: Scholtens, S, Postma, DS, Moffatt, MF, Panasevich, S, Granell, R, Henderson, AJ, Melén, E, Nyberg, F, Pershagen, G, Jarvis, D, Ramasamy, A, Wjst, M, Svanes, C, Bouzigon, E, Demenais, F, Kauffmann, F, Siroux, V, Von Mutius, E, Ege, MJ, Braun-Fahrländer, C, Genuneit, J, Brunekreef, B, Smit, HA, Wijga, AH, Kerkhof, M, Curjuric, I, Imboden, M, Thun, GA, Probst-Hensch, N, Freidin, MB, Bragina, EI, Deev, IA, Puzyrev, VP, Daley, D, Park, J, Becker, A, Chan-Yeung, M, Kozyrskyj, AL, Pare, P, Marenholz, I, Lau, S, Keil, T, Lee, YA, Kabesch, M, Wijmenga, C, Franke, L, Nolte, IM, Vonk, J, Kumar, A, Farrall, M, Cookson, WOCM, Strachan, DP, Koppelman, GH, Boezen, HM

Publikováno v: J. Allergy Clin. Immunol. 133, 885-888 (2014)
Journal of Allergy and Clinical Immunology, 133(3), 885-888. MOSBY-ELSEVIER
The Journal of Allergy and Clinical Immunology

To the Editor: Complex diseases, including asthma, have genetic and environmental origins. Genome-wide association studies have identified multiple genes for the development of asthma, yet they only explain a limited proportion of asthma heritability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c094972d3054b520d3f988a91f5c6d
https://doi.org/10.1016/j.jaci.2013.08.049