Zobrazeno 1 - 10
of 910
pro vyhledávání: '"Marenduzzo, D"'
We propose a polymer model for the dynamics of chromatin replication in three dimensional space. Our simulations indicate that both immobile and tracking replisomes may self-assemble during the process, reconciling previous apparently discordant expe
Externí odkaz:
http://arxiv.org/abs/2312.11275
Publikováno v:
Nature Commun. 14, 1096 (2023)
Active fluid droplets are a class of soft materials exhibiting autonomous motion sustained by an energy supply. Such systems have been shown to capture motility regimes typical of biological cells and are ideal candidates as building-block for the fa
Externí odkaz:
http://arxiv.org/abs/2205.02762
Publikováno v:
Sci Rep 10, 15936 (2020)
We use computer simulations to study the morphology and rheological properties of a bidimensional emulsion resulting from a mixture of a passive isotropic fluid and an active contractile polar gel, in the presence of a surfactant that favours the emu
Externí odkaz:
http://arxiv.org/abs/2010.14910
Understanding the interactions between viruses and surfaces or interfaces is important, as they provide the principles underpinning the cleaning and disinfection of contaminated surfaces. Yet, the physics of such interactions is currently poorly unde
Externí odkaz:
http://arxiv.org/abs/2010.12530
Autor:
Gilbert, N., Marenduzzo, D.
Publikováno v:
Chromosome Research 25, 1 (2017)
This is an introduction to the special issue Genome organization: experiments and simulations, published in Chromosome Research, volume 25, issue 1 (2017).
Comment: 7 pages, 1 figures
Comment: 7 pages, 1 figures
Externí odkaz:
http://arxiv.org/abs/2010.08464
Autor:
Brackley, C. A., Michieletto, D., Mouvet, F., Johnson, J., Kelly, S., Cook, P. R., Marenduzzo, D.
Publikováno v:
Nucleus 7, 453 (2016)
We discuss a polymer model for the 3D organization of human chromosomes. A chromosome is represented by a string of beads, with each bead being "colored" according to 1D bioinformatic data (e.g., chromatin state, histone modification, GC content). In
Externí odkaz:
http://arxiv.org/abs/2010.07135
Publikováno v:
Soft Matter 15, 5995 (2019)
We present a generic coarse-grained model to describe molecular motors acting on polymer substrates, mimicking, for example, RNA polymerase on DNA or kinesin on microtubules. The polymer is modeled as a connected chain of beads; motors are represente
Externí odkaz:
http://arxiv.org/abs/2010.06424
Autor:
Brackley, C. A., Johnson, J., Michieletto, D., Morozov, A. N., Nicodemi, M., Cook, P. R., Marenduzzo, D.
Publikováno v:
Nucleus 9, 95 (2018)
Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangement of the CTCF binding motifs that stabilize loops, and extrusion is t
Externí odkaz:
http://arxiv.org/abs/2010.02548
Publikováno v:
Soft Matter 15, 6896 (2019)
We study the dynamics of quasi-two-dimensional concentrated suspensions of colloidal particles in active gels by computer simulations. Remarkably, we find that activity induces a dynamic clustering of colloids even in the absence of any preferential
Externí odkaz:
http://arxiv.org/abs/1910.04599
Publikováno v:
Phys. Rev. Lett. 124, 198101 (2020)
Vital biological processes such as genome repair require fast and efficient binding of selected proteins to specific target sites on DNA. Here we propose an active target search mechanism based on "chromophoresis", the dynamics of DNA-binding protein
Externí odkaz:
http://arxiv.org/abs/1908.06671