Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Maren Luchtefeld"'
Autor:
Raghav Oberoi, Jutta Schuett, Harald Schuett, Ann-Kathrin Koch, Maren Luchtefeld, Karsten Grote, Bernhard Schieffer
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0160145 (2016)
It is well known that atherosclerotic inflammatory vascular disease is critically driven by oxidized lipids and cytokines. In this regard, tumor necrosis factor (TNF)-α is known as a crucial mediator of early pro-atherosclerotic events. Epidemiologi
Externí odkaz:
https://doaj.org/article/38c7b842d45f4dcb95026b40ebcbe509
Autor:
Raghav Oberoi, Eskindir P Bogalle, Lukas A Matthes, Harald Schuett, Ann-Kathrin Koch, Karsten Grote, Bernhard Schieffer, Jutta Schuett, Maren Luchtefeld
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137924 (2015)
Lipocalin (LCN) 2 is associated with multiple acute and chronic inflammatory diseases but the underlying molecular and cellular mechanisms remain unclear. Here, we investigated whether LCN2 is released from macrophages and contributes to pro-atherosc
Externí odkaz:
https://doaj.org/article/0cc520b1b5bc4b989d6a250e373d1c47
Autor:
Jörg Eberhard, Karsten Grote, Maren Luchtefeld, Wieland Heuer, Harald Schuett, Dimitar Divchev, Ralph Scherer, Ruth Schmitz-Streit, Daniela Langfeldt, Nico Stumpp, Ingmar Staufenbiel, Bernhard Schieffer, Meike Stiesch
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55265 (2013)
ObjectivesWe here investigated whether experimental gingivitis enhances systemic markers of inflammation which are also known as surrogate markers of atherosclerotic plaque development.BackgroundGingivitis is a low-level oral infection induced by bac
Externí odkaz:
https://doaj.org/article/f598b0ba59e34ff59b1ebc523098a44d
Autor:
Christina Grothusen, Harald Schuett, Anja Hillmer, Stefan Lumpe, Karsten Grote, Matthias Ballmaier, Andre Bleich, Silke Glage, Uwe J F Tietge, Maren Luchtefeld, Bernhard Schieffer
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51608 (2012)
While the impact of inflammation as the substantial driving force of atherosclerosis has been investigated in detail throughout the years, the influence of negative regulators of pro-atherogenic pathways on plaque development has remained largely unk
Externí odkaz:
https://doaj.org/article/f6b4cd3620c2498ca2ca9b683125b5d5
Autor:
Maren Luchtefeld, Christoph Preuss, Frank Rühle, Eskindir P Bogalle, Anika Sietmann, Stefanie Figura, Werner Müller, Karsten Grote, Bernhard Schieffer, Monika Stoll
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19427 (2011)
Elevated levels of acute phase proteins (APP) are often found in patients with cardiovascular diseases. In a previous study, we demonstrated the importance of the IL-6-gp130 axis -as a key regulator of inflammatory acute phase signaling in hepatocyte
Externí odkaz:
https://doaj.org/article/5b09b56de27849708c6e1ada53e513df
Autor:
Jutta Schuett, Silke Pretzer, Karsten Grote, Raghav Oberoi, Maren Luchtefeld, Ann-Kathrin Koch, Harald Schuett, Bernhard Schieffer
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(6)
NADPH oxidase-generated reactive oxygen species (ROS) from immune cells are well known to be important for pathogen killing in response to TLR ligands. Here, we investigated a new aspect of NADPH oxidase in the TLR2/6-induced release of the immunolog
Autor:
René Oestreich, Harald Schuett, Dimitar Divchev, Bernhard Schieffer, Uwe J. F. Tietge, Tibor Kempf, Georg H. Waetzig, Dirk Seegert, Kai C. Wollert, Udo Bavendiek, Stefan Rose-John, Anja Hillmer, Karsten Grote, Maren Luchtefeld, Wijtske Annema, Johann von Felden
Publikováno v:
Arteriosclerosis thrombosis and vascular biology, 32(2), 281-290. LIPPINCOTT WILLIAMS & WILKINS
Objective— Transsignaling of interleukin (IL)-6 is a central pathway in the pathogenesis of disorders associated with chronic inflammation, such as Crohn disease, rheumatoid arthritis, and inflammatory colon cancer. Notably, IL-6 also represents an
Autor:
Maren Luchtefeld, Bernhard Schieffer
Publikováno v:
Trends in Cardiovascular Medicine. 21:211-216
The CC chemokine receptor 7 (CCR7) and its ligands CCL19 and CCL21 essentially contribute to both immunity and tolerance by directing T cells and antigen-presenting dendritic cells (DCs) to and within lymph organs. In the pathogenesis of atherosclero
Autor:
Helmut Drexler, Werner Müller, Harald Schuett, Ezequiel Tallone, Maren Luchtefeld, Joanna Jagielska, Bernhard Schieffer, Gustavo Salguero, Rene Schley, Karsten Grote
Publikováno v:
Hypertension. 54:1035-1042
Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid
Publikováno v:
Thrombosis and Haemostasis. 102:215-222
SummaryThe importance of inflammation as a driver of pathology is no longer confined to autoimmune and infectious diseases. In line with convincing experimental data as well as abundant clinical findings the current view of atherosclerosis points to