Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marek Wanior"'
Autor:
Ufuk Erdogdu, Nadezda Dolgikh, Stephanie Laszig, Vinzenz Särchen, Michael T. Meister, Marek Wanior, Stefan Knapp, Cathinka Boedicker
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 2, Pp 109-119 (2022)
BH3 mimetics are promising novel anticancer therapeutics. By selectively inhibiting BCL-2, BCL-xL, or MCL-1 (i.e. ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis. As Bromodomain and Extra T
Externí odkaz:
https://doaj.org/article/0403c2302550453288f621f27f8c9d7f
Autor:
Mark Wroblewski, Marina Scheller-Wendorff, Florian Udonta, Raimund Bauer, Jara Schlichting, Lin Zhao, Isabel Ben Batalla, Victoria Gensch, Sarina Päsler, Lei Wu, Marek Wanior, Hanna Taipaleenmäki, Simona Bolamperti, Zeynab Najafova, Klaus Pantel, Carsten Bokemeyer, Jun Qi, Eric Hesse, Stefan Knapp, Steven Johnsen, Sonja Loges
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (
Externí odkaz:
https://doaj.org/article/118c713a5b524973a8616839fbd088f7
Autor:
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilman Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
Publikováno v:
Journal of Medicinal Chemistry. 66:837-854
The highly conserved catalytic sites in protein kinases make it difficult to identify ATP competitive inhibitors with kinome-wide selectivity. Serendipitously, during a dedicated fragment campaign for the focal adhesion kinase (FAK), a scaffold that
Autor:
Andreas C. Joerger, Xiaomin Ni, Sebastian Mathea, Andreas Krämer, Stefan Knapp, Marek Wanior, David Heidenreich, Tamara Göbel, Svenja Simonyi, Franziska Preuss, Astrid S. Kahnt
Publikováno v:
Journal of Medicinal Chemistry. 63:14680-14699
Accessibility of the human genome is modulated by the ATP-driven SWI/SNF chromatin remodeling multiprotein complexes BAF (BRG1/BRM-associated factor) and PBAF (polybromo-associated BAF factor), which involves reading of acetylated histone tails by th
Autor:
Stefan Knapp, Christina Grimm, Cathinka Boedicker, Michal R. Schweiger, Marek Wanior, Michael Meister, Michelle Hussong, Julius C. Enßle, Nadezda Dolgikh, Simone Fulda
Publikováno v:
Oncogene. 39:3837-3852
Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to t
Publikováno v:
Oncogene
Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7068a1ed7d1596a963e991b5675029e
http://publikationen.ub.uni-frankfurt.de/files/62385/s41388_021_01781_x.pdf
http://publikationen.ub.uni-frankfurt.de/files/62385/s41388_021_01781_x.pdf
Autor:
Stephanie Heinzlmeir, Bikash Adhikari, Bernhard Kuster, Ashwin Narain, Pranjali Bhandare, Jessica Denise Schwarz, Lars Schönemann, Mathias Diebold, Nevenka Dudvarski Stankovic, Julia Hofstetter, Lorenz Eing, Martin Schröder, Stefan Knapp, Elmar Wolf, Apoorva Baluapuri, Christoph A. Sotriffer, Jelena Bozilovic, Marek Wanior, Andreas Schlosser, Markus Vogt
Publikováno v:
Nature Chemical Biology
Nature chemical biology
Nature chemical biology
The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. Although the catalytic activity of AURORA-A is essential for its mitotic function, recent reports indicate an additional non-catalytic fun
Autor:
Maike Windbergs, Marius Friedrich, Xiaomin Ni, Sun-Yee Cheung, Apirat Chaikuad, Marek Wanior, Manfred Schubert-Zsilavecz, Simone Schierle, Jan Heering, Ewgenij Proschak, Giuseppe Faudone, Viktoria Planz, Thomas Hanke, Whitney Kilu, Oliver Werz, Stefan Knapp, Daniel Merk
The nuclear peroxisome proliferator-activated receptor γ has well-validated therapeutic potential in metabolic, inflammatory, and neurodegenerative pathologies, but its activation is also associated with marked adverse effects and novel modes of PPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6e187101295eb2e80dd7d29c60b7f2
https://publica.fraunhofer.de/handle/publica/263782
https://publica.fraunhofer.de/handle/publica/263782
Autor:
Lin Zhao, Lei Wu, Stefan Knapp, Klaus Pantel, Isabel Ben Batalla, Mark Wroblewski, Jara Schlichting, Simona Bolamperti, Raimund Bauer, Marina Scheller-Wendorff, Florian Udonta, Jun Qi, Steven A. Johnsen, Sonja Loges, Sarina Päsler, Victoria Gensch, Eric Hesse, Carsten Bokemeyer, Hanna Taipaleenmäki, Zeynab Najafova, Marek Wanior
Publikováno v:
Haematologica. 103:939-948
Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (
Autor:
Cathinka, Boedicker, Michelle, Hussong, Christina, Grimm, Nadezda, Dolgikh, Michael T, Meister, Julius C, Enßle, Marek, Wanior, Stefan, Knapp, Michal R, Schweiger, Simone, Fulda
Publikováno v:
Oncogene. 39(19)
Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to t