Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marek M. Nagiec"'
Autor:
Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary Clish, Kiran Musunuru, Jeremy R Duvall, Michael Foley, Jose R Perez, Michelle A J Palmer
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120295 (2015)
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasm
Externí odkaz:
https://doaj.org/article/462e5962fcb24652928b7b20d53c53e5
Autor:
Marek M, Nagiec, Jeremy R, Duvall, Adam P, Skepner, Eleanor A, Howe, Jessica, Bastien, Eamon, Comer, Jean-Charles, Marie, Stephen E, Johnston, Joseph, Negri, Michelle, Eichhorn, Julien, Vantourout, Clary, Clish, Kiran, Musunuru, Michael, Foley, Jose R, Perez, Michelle A J, Palmer
Publikováno v:
MedChemComm. 9(11)
Increased expression of the Tribbles pseudokinase 1 gene (TRIB1) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and myocardial infarction. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22e105aa4f33d9ef4ee264e0519ebeba
https://pubmed.ncbi.nlm.nih.gov/30542533
https://pubmed.ncbi.nlm.nih.gov/30542533
Autor:
Maureen K. Highkin, Matthew D. McReynolds, Matthew J. Saabye, John W. Rains, Kaliapan Iyanar, Jeffrey Carroll, Jill Chrencik, Matthew P. Yates, Jeffrey A. Scholten, Gina M. Jerome, Marek M. Nagiec, Mark E. Schnute
Publikováno v:
Journal of medicinal chemistry. 60(6)
Sphingosine kinase (SphK) is the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phosphate (S1P). S1P promotes cell growth, survival, and migration and is a key regulator of lymphocyte trafficking. Inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c23d10cabd117ff2077923f1706da7
https://pubmed.ncbi.nlm.nih.gov/28231433
https://pubmed.ncbi.nlm.nih.gov/28231433
Autor:
Stuart L. Schreiber, Michael Foley, Andrew Germain, Willmen Youngsaye, Timothy A. Lewis, Lawrence MacPherson, Michelle Palmer, Marek M. Nagiec, Christina Scherer, Han-Je Kim, Partha P. Nag, Michel Weïwer, BenjaminZ. Stanton, Chris Dockendorff, Melissa Bennion, Amal Ting, Jose Perez, Sara J. Buhrlage, Linlong Xue
Publikováno v:
ACS Medicinal Chemistry Letters
Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle robotnikinin. Analogues were prepared using a modular and efficient build-couple-pair (BCP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc04990686166e13543e4d28b5f1f68
https://doi.org/10.1021/ml300172p
https://doi.org/10.1021/ml300172p
Autor:
Michelle Kraus, Jay M. Wendling, Olga V. Nemirovskiy, John W. Rains, Vincent Peterkin, Laura E. Zawadzke, Hideji Fujiwara, Ciarán N. Cronin, Troii Hall, Tom Kasten, Maureen K. Highkin, Gina M. Jerome, Arthur J. Wittwer, Matthew P. Yates, Shinji Ogawa, Jeffrey A. Scholten, Jill Chrencik, Marek M. Nagiec, Matthew D. McReynolds, Kaliapan Iyanar, Mark E. Schnute, Kristin Cukyne, Matthew J. Saabye, Richard M. Broadus
Publikováno v:
Biochemical Journal. 444:79-88
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c29039f87435103ee01d57e1663842f
https://doi.org/10.1042/bj20111929
https://doi.org/10.1042/bj20111929
Autor:
Olga V. Nemirovskiy, Jaime L. Masferrer, Grace E. Munie, William A. LaMarr, Maureen K. Highkin, John W. Rains, Marek M. Nagiec, Matthew P. Yates
Publikováno v:
SLAS Discovery. 16:272-277
To facilitate discovery of compounds modulating sphingosine-1-phosphate (S1P) signaling, the authors used high-throughput mass spectrometry technology to measure S1P formation in human whole blood. Since blood contains endogenous sphingosine (SPH) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e0fed6a3d09dfcbd8fa986e16ef53b
https://doi.org/10.1177/1087057110391656
https://doi.org/10.1177/1087057110391656
Publikováno v:
Biochemistry. 43:8483-8493
The effect of 26 different membrane-perturbing agents on the activity and phase distribution of inositol phosphorylceramide synthase (IPC synthase) activity in crude Candida albicans membranes was investigated. The nonionic detergents Triton X-100, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1200ea742bb222fb3b1542c4f3461f1f
https://doi.org/10.1021/bi049141u
https://doi.org/10.1021/bi049141u
Publikováno v:
Biochemical and Biophysical Research Communications. 307:369-374
Standard methods for evaluating the target specificity of antimicrobial agents often involve the use of microorganisms with altered expression of selected targets and thus either more resistant or more susceptible to target specific inhibitors. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b572cbbab777210d01aecd65ea7ef99
https://doi.org/10.1016/s0006-291x(03)01164-1
https://doi.org/10.1016/s0006-291x(03)01164-1
Autor:
Kiran Musunuru, Adam Skepner, Marek M. Nagiec, Clary B. Clish, Aravind Subramanian, Michelle Eichhorn, Joseph Negri, Michelle Palmer, Jeremy R. Duvall, José Carlos Rodríguez Pérez, Eamon Comer, Michael Foley, Giovanni Muncipinto
Publikováno v:
The FASEB Journal. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b637c03ef96cbf7686e40cafd433f69e
https://doi.org/10.1096/fasebj.28.1_supplement.998.1
https://doi.org/10.1096/fasebj.28.1_supplement.998.1
Publikováno v:
Antimicrobial agents and chemotherapy. 53(2)
By using a detergent-washed membrane preparation, the interaction of the fungal natural product inhibitor aureobasidin A (AbA) with inositol phosphorylceramide synthase (IPC synthase) was studied by kinetic analysis of wild-type and mutant enzyme-cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724dd76bd1b6f087603f650fda31e22d
https://pubmed.ncbi.nlm.nih.gov/19047657
https://pubmed.ncbi.nlm.nih.gov/19047657