Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marek Liyanage"'
Autor:
Kevin R. Shreder, Tyzoon K. Nomanbhoy, Ayako Nakamura, Anna Katrin Szardenings, Shigeki Seto, Jonathan S. Rosenblum, Brandon Leen, Oana Cociorva, Kai Nakamura, Bei Li, Marek Liyanage, John W. Kozarich, Qiang Li, Yasushi Kohno, Kazuhiro Yumoto, Kyoko Okada, Masahiro Nomura, Melissa C. Zhang, Arwin Aban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5948-5951
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this
Autor:
Helge Weissig, Doris Pik-Yiu Chun, Tyzoon K. Nomanbhoy, Min Wu, Marek Liyanage, A. Katrin Szardenings, Stephen Tanner, Arwin Aban, Matthew P. Patricelli, John W. Kozarich
Publikováno v:
Biochemistry. 46:350-358
The central role of protein kinases in signal transduction pathways has generated intense interest in targeting these enzymes for a wide range of therapeutic indications. Here we report a method for identifying and quantifying protein kinases in any
Autor:
Allen E. Coleman, Stacie M. Anderson, Marek Liyanage, Thomas Ried, Daniel G. Pankratz, Carrolee Barlow, Zoë Weaver, Anthony Wynshaw-Boris
Publikováno v:
Blood. 96:1940-1946
Atm-deficient mice (Atm−/−) recapitulate many aspects of the ataxia telangiectasia (AT) syndrome, including the susceptibility to tumors of lymphoid origin. To investigate the mechanism of tumorigenesis, we have examined a panel of 8 thymic lymph
Autor:
Ulli Weier, Michael P. Diamond, Alexandre N. Ermilov, Thomas M. Reid, Allen E. Coleman, Peter Nagy, D. Dozortsev, Marek Liyanage
Publikováno v:
Fertility and Sterility. 73:366-371
Objective: To investigate the arrangement of chromosomes within pronuclei-stage mouse zygotes. Design: In vitro study. Setting: Academic medical center. Patient(s): None. Intervention(s): None. Main Outcome Measure(s): Location of major α-satellite
Autor:
Stan du Manoir, Allen E. Coleman, Evelin Schröck, Stephen J McCormack, Zoë Weaver, Robert B. Dickson, Marek Liyanage, Thomas Ried
Publikováno v:
Genes, Chromosomes and Cancer. 25:251-260
Mice carrying the MMTV-cmyc transgene develop mammary tumors at 9 to 12 months of age. Little is known about karyotypic changes in this model of human breast cancer. We have developed and applied molecular cytogenetic techniques to study chromosomal
Autor:
Stephen P. Jackson, Scott T. Rottinghaus, Peter B. Moens, Anthony Wynshaw-Boris, Danilo A. Tagle, Thomas Ried, Madalina Tarsounas, Carrolee Barlow, Marek Liyanage, Kunio Nagashima, Kevin M. Brown
Publikováno v:
Europe PubMed Central
Infertility is a common feature of the human disorder ataxia-telangiectasia and Atm-deficient mice are completely infertile. To gain further insight into the role of ATM in meiosis, we examined meiotic cells in Atm-deficient mice during development.
Autor:
F. C. Von Lintig, Gerry R. Boss, Marek Liyanage, C. L. Jorcyk, Min-Ling Liu, Jeffrey E. Green, Thomas Ried, Masa-Aki Shibata
Publikováno v:
Oncogene. 17:2403-2411
We have previously documented that transgenic mice expressing SV40 Tag regulated by the rat prostatic steroid-binding protein C3(1) 5'-flanking region display multistage mammary tumorigenesis. To delineate genetic changes associated with mammary tumo
Autor:
Kai Nakamura, Qiang Li, Tyzoon K. Nomanbhoy, Ann Yu-Jung Shih, Helge Weissig, Oana Cociorva, Lan Pham, John W. Kozarich, Yi Hu, Melissa C. Zhang, Marek Liyanage, Julia Cajica, Kevin R. Shreder, Arwin Aban, Bei Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(18)
As the result of a rhJNK1 HTS, the imidazo[1,2-a]quinoxaline 1 was identified as a 1.6 μM rhJNK1 inhibitor. Optimization of this compound lead to AX13587 (rhJNK1 IC50 = 160 nM) which was co-crystallized with JNK1 to identify key molecular interactio
Autor:
S du Manoir, Robert B. Dickson, Anthony Wynshaw-Boris, Malcolm A. Ferguson-Smith, Allen E. Coleman, Evelin Schröck, Thomas Ried, T Veldman, Marek Liyanage, Carrolee Barlow, Siegfried Janz, S McCormack, Johannes Wienberg
Publikováno v:
Nature Genetics. 14:312-315
Murine models of human carcinogenesis are exceedingly valuable tools to understand genetic mechanisms of neoplastic growth. The identification of recurrent chromosomal rearrangements by cytogenetic techniques serves as an initial screening test for t
Autor:
Thomas Ried, Richard Paylor, Yosef Shiloh, Danilo A. Tagle, Anthony Wynshaw-Boris, Michael Eckhaus, Shinji Hirotsune, Marek Liyanage, Francis J Collins, Jacqueline N. Crawley, Carrolee Barlow
Publikováno v:
Cell. 86:159-171
A murine model of ataxia telangiectasia was created by disrupting the Atm locus via gene targeting. Mice homozygous for the disrupted Atm allele displayed growth retardation, neurologic dysfunction, male and female infertility secondary to the absenc