Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Marek Kovar"'
Autor:
Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A. McNeish, Michal J. Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that h
Externí odkaz:
https://doaj.org/article/51ecc26da57243349eb37f9d6e8d150d
Autor:
Ulrich Moebius, Radek Špíšek, David Béchard, Zuzana Antosova, Nada Podzimkova, Irena Adkins, Klara Danova, Lenka Palova Jelinkova, Katerina Behalova, Petr Danek, Matej Fabisik, Kamila Hladikova, Nataliia Kalynovska, Lucie Kosinova, Pavel Marasek, Vladyslav Mazhara, Jan Praslicka, Katerina Sajnerova, Milada Sirova, Marek Kovar, Martin Steegmaier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d46b7e812ed543c387a8980b697d76c7
Autor:
Peter Holicek, Iva Truxova, Jana Rakova, Cyril Salek, Michal Hensler, Marek Kovar, Milan Reinis, Romana Mikyskova, Josef Pasulka, Sarka Vosahlikova, Hana Remesova, Iva Valentova, Daniel Lysak, Monika Holubova, Petr Kaspar, Jan Prochazka, Lenka Kasikova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-12 (2023)
Abstract While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust type I IFN production in the tumor microenvironment promotes cancer immunosurveillance and
Externí odkaz:
https://doaj.org/article/f8edc52886a84c80a88c6cee32d03c15
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Loss of muscle mass occurs rapidly during critical illness and negatively affects quality of life. The incidence of clinically significant muscle wasting in critically ill patients is unclear. This study aimed to assess the incidence of and
Externí odkaz:
https://doaj.org/article/fd0e28df3f274238b3ae4cd3a7dfebed
Autor:
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Publikováno v:
eLife, Vol 12 (2023)
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity. In this study, we identified that Tregs increase the quo
Externí odkaz:
https://doaj.org/article/1259c927d0e9455aaea1c7377dffc5bd
Autor:
Zuzana Antosova, Nada Podzimkova, Jakub Tomala, Katerina Augustynkova, Katerina Sajnerova, Eva Nedvedova, Milada Sirova, Guy de Martynoff, David Bechard, Ulrich Moebius, Marek Kovar, Radek Spisek, Irena Adkins
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
SOT101 is a superagonist fusion protein of interleukin (IL)-15 and the IL-15 receptor α (IL-15Rα) sushi+ domain, representing a promising clinical candidate for the treatment of cancer. SOT101 among other immune cells specifically stimulates natura
Externí odkaz:
https://doaj.org/article/f6cbe7a311f44d1492d58b49afd67953
Autor:
Marek Kovar, Katarina Olsovska
Publikováno v:
Journal of Central European Agriculture, Vol 21, Iss 2, Pp 275-284 (2020)
In the pot experiments with commercial genotypes of common spinach (Spinacia oleracea L.) and New Zealand spinach (Tetragonia tetragonoides (Pall.) Kuntze) genotypic differences were studied in the capacity for osmotic adjustment occurred under progr
Externí odkaz:
https://doaj.org/article/ea52dfe462a146faa83e3312d05483bd
Autor:
Jakub Tomala, Petra Weberova, Barbora Tomalova, Zuzana Jiraskova Zakostelska, Ladislav Sivak, Jirina Kovarova, Marek Kovar
Publikováno v:
eLife, Vol 10 (2021)
Complexes of IL-2 and JES6-1 mAb (IL-2/JES6) provide strong sustained IL-2 signal selective for CD25+ cells and thus they potently expand Treg cells. IL-2/JES6 are effective in the treatment of autoimmune diseases and in protecting against rejection
Externí odkaz:
https://doaj.org/article/ba46fe21f6f442f593d162462e122627
Autor:
Caleb R Glassman, Leon Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovar, Paul Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia
Publikováno v:
eLife, Vol 10 (2021)
Interleukin-2 is a pleiotropic cytokine that mediates both pro- and anti-inflammatory functions. Immune cells naturally differ in their sensitivity to IL-2 due to cell type and activation state-dependent expression of receptors and signaling pathway
Externí odkaz:
https://doaj.org/article/57746b1870ed4f558e975b56d281ba02
Autor:
Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML). However, ICIs targeting programmed cell death 1 (PDCD1, best known
Externí odkaz:
https://doaj.org/article/7aa2896ab527498bac5610f866169e29