Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Marek Kovář"'
Autor:
Martin Studenovský, Anna Rumlerová, Jiřina Kovářová, Barbora Dvořáková, Ladislav Sivák, Libor Kostka, Daniel Berdár, Tomáš Etrych, Marek Kovář
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1201 (2022)
Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubili
Externí odkaz:
https://doaj.org/article/a7795b50f5954a6a94006489cd901eb0
Autor:
Libor Kostka, Lenka Kotrchová, Eva Randárová, Carolina A. Ferreira, Iva Malátová, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovář, Weibo Cai, Milada Šírová, Tomáš Etrych
Publikováno v:
Journal of Controlled Release. 353:549-562
Nanomedicines are considered next generation therapeutics with advanced therapeutic properties and reduced side effects. Herein, we introduce tailored linear and star-like water-soluble nanosystems as stimuli-sensitive nanomedicines for the treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07af6165a706fb2d9b5868045d5ab1a8
https://doi.org/10.1016/j.jconrel.2022.11.060
https://doi.org/10.1016/j.jconrel.2022.11.060
Autor:
Libor Kostka, Ladislav Sivák, Vladimír Šubr, Jiřina Kovářová, Milada Šírová, Blanka Říhová, Radislav Sedlacek, Tomáš Etrych, Marek Kovář
Publikováno v:
Biomacromolecules. 23(6)
The derivative of protease inhibitor ritonavir (5-methyl-4-oxohexanoic acid ritonavir ester; RD) was recently recognized as a potent P-gp inhibitor and cancerostatic drug inhibiting the proteasome and STAT3 signaling. Therefore, we designed high-mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fa63dd524b409f1cd2bde2cb3226ff
https://pubmed.ncbi.nlm.nih.gov/35584053
https://pubmed.ncbi.nlm.nih.gov/35584053
Autor:
Jana Kousalová, Milada Šírová, Libor Kostka, Vladimír Šubr, Jiřina Kovářová, Kateřina Běhalová, Martin Studenovský, Marek Kovář, Tomáš Etrych
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1097da685320f0d4e0cbf8914a798666
https://pubmed.ncbi.nlm.nih.gov/35779856
https://pubmed.ncbi.nlm.nih.gov/35779856
Autor:
Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A. McNeish, Michal J. Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that h
Externí odkaz:
https://doaj.org/article/51ecc26da57243349eb37f9d6e8d150d
Autor:
Libor Kostka, Jiřina Kovářová, Michal Kraus, Radislav Sedlacek, Jitka Fucikova, Radek Spisek, Ladislav Sivák, Milada Šírová, Eva Randárová, Blanka Říhová, Barbora Dvořáková, Michaela Vondráčková, Petr Makovický, Tomáš Etrych, Sarka Vosahlikova, Vladimir Subr, Marek Kovář, Martin Studenovský, Jakub Tomala
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 332
Drug repurposing is a promising strategy for identifying new applications for approved drugs. Here, we describe a polymer biomaterial composed of the antiretroviral drug ritonavir derivative (5-methyl-4-oxohexanoic acid ritonavir ester; RD), covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3112a15f63a96388f784441033a5699f
https://pubmed.ncbi.nlm.nih.gov/33722611
https://pubmed.ncbi.nlm.nih.gov/33722611
Autor:
Vlastimil Král, František Štěpánek, Denisa Lizoňová, Michal Pechar, Marek Kovář, Robert Pola, Monika Majerská
Publikováno v:
RSC Advances. 8:21679-21689
The systemic application of highly potent drugs such as cytostatics poses the risks of side effects, which could be reduced by using a carrier system able to specifically deliver the encapsulated drug to the target tissue. Essential components of a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d93d3194bd7236ba4171a74eb4d1a84
https://doi.org/10.1039/c8ra03487g
https://doi.org/10.1039/c8ra03487g
Autor:
Peter Holicek, Iva Truxova, Jana Rakova, Cyril Salek, Michal Hensler, Marek Kovar, Milan Reinis, Romana Mikyskova, Josef Pasulka, Sarka Vosahlikova, Hana Remesova, Iva Valentova, Daniel Lysak, Monika Holubova, Petr Kaspar, Jan Prochazka, Lenka Kasikova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-12 (2023)
Abstract While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust type I IFN production in the tumor microenvironment promotes cancer immunosurveillance and
Externí odkaz:
https://doaj.org/article/f8edc52886a84c80a88c6cee32d03c15
Autor:
Milada Šírová, T Etrych, Pavel Rossmann, Blanka Říhová, Karel Ulbrich, Jiří Strohalm, Marek Kovář, B. Tomalová
Publikováno v:
Polymer Chemistry. 6:160-170
Here we present the polymer conjugates where the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing docetaxel (DTX) attached by a pH-sensitive hydrazone bond. DTX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb636faedbff5b757a8978c8a4f7d44
https://doi.org/10.1039/c4py01120a
https://doi.org/10.1039/c4py01120a
Publikováno v:
Applied Sciences, Vol 14, Iss 10, p 4049 (2024)
The Cornus mas L. fruit is well known for having a high presence of bioactive substances that include phenolic compounds, anthocyanins, vitamins, flavonoids, carotenoids, and ursolic acid. The health-promoting effects of those substances are mainly a
Externí odkaz:
https://doaj.org/article/e0b183200af04043a44f014ca8090bd7