Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marek J Kobylarz"'
Autor:
Marek J Kobylarz, Jonathan M Goodwin, Zhao B Kang, John W Annand, Sarah Hevi, Ellen O'Mahony, Gregory McAllister, John Reece-Hoyes, Qiong Wang, John Alford, Carsten Russ, Alicia Lindeman, Martin Beibel, Guglielmo Roma, Walter Carbone, Judith Knehr, Joseph Loureiro, Christophe Antczak, Dmitri Wiederschain, Leon O Murphy, Suchithra Menon, Beat Nyfeler
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235551 (2020)
VPS34 is a key regulator of endomembrane dynamics and cargo trafficking, and is essential in cultured cell lines and in mice. To better characterize the role of VPS34 in cell growth, we performed unbiased cell line profiling studies with the selectiv
Externí odkaz:
https://doaj.org/article/405ec165a99f440886a38bc379ff0399
Autor:
Marek J. Kobylarz, Leon Murphy, William E. Dowdle, Rowena DeJesus, Jonathan M. Goodwin, Alicia Lindeman, Beat Nyfeler, Gregory McAllister, Zuncai Wang, Gregory R. Hoffman, Ramnik J. Xavier, Philip Bergman
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2341-2356 (2017)
Iron is vital for many homeostatic processes and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef54941eaa793724f625867ca74b743
https://doi.org/10.1016/j.celrep.2017.08.034
https://doi.org/10.1016/j.celrep.2017.08.034
Autor:
Marek J. Kobylarz, Lindsay D. Eltis, Eugene Kuatsjah, Alvin Liu, Michael E. P. Murphy, Meghan M. Verstraete
Publikováno v:
J Biol Chem
Lignostilbene-α,β-dioxygenase A (LsdA) from the bacterium Sphingomonas paucimobilis TMY1009 is a nonheme iron oxygenase that catalyzes the cleavage of lignostilbene, a compound arising in lignin transformation, to two vanillin molecules. To examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e785756aa280b7874548a1f693b01a6
https://pubmed.ncbi.nlm.nih.gov/31292192
https://pubmed.ncbi.nlm.nih.gov/31292192
Autor:
Meghan M, Verstraete, L Daniela, Morales, Marek J, Kobylarz, Slade A, Loutet, Holly A, Laakso, Tyler B, Pinter, Martin J, Stillman, David E, Heinrichs, Michael E P, Murphy
Publikováno v:
J Biol Chem
Staphylococcus aureus infection relies on iron acquisition from its host. S. aureus takes up iron through heme uptake by the iron-responsive surface determinant (Isd) system and by the production of iron-scavenging siderophores. Staphyloferrin B (SB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::646e48330c6645380b4dfc854df4d440
https://pubmed.ncbi.nlm.nih.gov/31197035
https://pubmed.ncbi.nlm.nih.gov/31197035
Autor:
Yunan Liu, Marek J. Kobylarz, David E. Heinrichs, Mathew S. F. Lee, Jason C. Grigg, Michael E. P. Murphy
Publikováno v:
Biochemistry
Staphylococcus aureus assembles the siderophore, staphyloferrin B, from l-2,3-diaminopropionic acid (l-Dap), α-ketoglutarate, and citrate. Recently, SbnA and SbnB were shown to produce l-Dap and α-ketoglutarate from O-phospho-l-serine (OPS) and l-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac612faf398186ac5d2b2e1b092c502
https://doi.org/10.1021/acs.biochem.5b01045
https://doi.org/10.1021/acs.biochem.5b01045
Autor:
Jessica R. Sheldon, Marek J. Kobylarz, Jason C. Grigg, Michael E. P. Murphy, David E. Heinrichs
Publikováno v:
Journal of Biological Chemistry. 289:33797-33807
In response to iron deprivation, Staphylococcus aureus produces staphyloferrin B, a citrate-containing siderophore that delivers iron back to the cell. This bacterium also possesses a second citrate synthase, SbnG, that is necessary for supplying cit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfb1b91bdb430cd83c6cd6360c74a1cf
https://doi.org/10.1074/jbc.m114.603175
https://doi.org/10.1074/jbc.m114.603175
Publikováno v:
The Journal of biological chemistry. 292(44)
Strain SYK-6 of the bacterium Sphingobium sp. catabolizes lignin-derived biphenyl via a meta-cleavage pathway. In this pathway, LigY is proposed to catalyze the hydrolysis of the meta-cleavage product (MCP) 4,11-dicarboxy-8-hydroxy-9-methoxy-2-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0a879984d304cda29ff40b714c02f74
https://pubmed.ncbi.nlm.nih.gov/28935670
https://pubmed.ncbi.nlm.nih.gov/28935670
Publikováno v:
ACS chemical biology. 12(7)
Many pathogenic bacteria including Staphylococcus aureus use iron-chelating siderophores to acquire iron. Iron uptake oxidoreductase (IruO), a flavin adenine dinucleotide (FAD)-containing nicotinamide adenine dinucleotide phosphate (NADPH)-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb83dc2362e3e4e5c0bef0d04df21326
https://pubmed.ncbi.nlm.nih.gov/28463500
https://pubmed.ncbi.nlm.nih.gov/28463500
Autor:
Jason C. Grigg, Michael E. P. Murphy, David E. Heinrichs, Shin Ichi J. Takayama, Dushyant K. Rai, Marek J. Kobylarz
Publikováno v:
Chemistry & Biology. 21(3):379-388
Summary L-2,3-diaminopropionic acid (L-Dap) is an amino acid that is a precursor of antibiotics and staphyloferrin B a siderophore produced by Staphylococcus aureus . SbnA and SbnB are encoded by the staphyloferrin B biosynthetic gene cluster and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6b97947a3cb54b9e1559373084df69
Publikováno v:
Journal of Biological Chemistry. 288:25749-25759
Staphylococcus aureus is a common hospital- and community-acquired bacterium that can cause devastating infections and is often multidrug-resistant. Iron acquisition is required by S. aureus during an infection, and iron acquisition pathways are pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87511038eb85b74d5f1185f72fca28da
https://doi.org/10.1074/jbc.m113.470518
https://doi.org/10.1074/jbc.m113.470518