Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Marek Duszyk"'
Publikováno v:
Chemical Biology & Drug Design. 80:992-1002
We demonstrate the effects on membrane of the tubulin-binding chemotherapy drugs: thiocolchicoside and taxol. Electrophysiology recordings across lipid membranes in aqueous phases containing drugs were used to investigate the drug effects on membrane
Autor:
Juraj Rievaj, Harissios Vliagoftis, Morley D. Hollenberg, Marek Duszyk, Courtney Davidson, Ahmed Nadeem
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 463:497-509
Protease-activated receptor 2 (PAR-2) is a G protein-coupled receptor possibly involved in the pathogenesis of asthma. PAR-2 also modulates ion transport in cultured epithelial cells, but these effects in native airways are controversial. The influen
Publikováno v:
The Journal of Biological Chemistry
Carnocyclin A (CclA) is a potent antimicrobial peptide from Carnobacterium maltaromaticum UAL307 that displays a broad spectrum of activity against numerous Gram-positive organisms. An amide bond links the N and C termini of this bacteriocin, imparti
Publikováno v:
Experimental Cell Research. 315:3028-3035
Cholesterol affects diverse biological processes, in many cases by modulating the function of integral membrane proteins. In this study we have investigated the role of cholesterol in the adenosine-dependent regulation of ion transport in colonic epi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788:1797-1803
Bacterial resistance to conventional antibiotics is a major challenge in controlling infectious diseases and has necessitated the development of novel approaches in antimicrobial therapy. One such approach is the use of antimicrobial peptides, such a
Autor:
Akiko Niibori, Tsukasa Okiyoneda, Masahito Ikawa, Kazutsune Harada, Marek Duszyk, Mary Ann Suico, Marek Michalak, Tsuyoshi Shuto, Taijun Kohno, Hirofumi Kai, Ikuo Wada
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783:1585-1594
Cystic fibrosis (CF) is caused by the mutation in CF transmembrane conductance regulator (CFTR), a cAMP-dependent Cl(-) channel at the plasma membrane of epithelium. The most common mutant, DeltaF508 CFTR, has competent Cl(-) channel function, but fa
Autor:
Shaohua Wang, Qian Wang, Yuliang Wu, Jingfeng Tang, Jiancheng Tu, Xing-Zhen Chen, Drew Nahirney, Wang Zheng, Marek Duszyk, Qiaolin Hu
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 92(6)
Mutations in polycystin-1, polycystin-2, or fibrocystin account for autosomal dominant or recessive polycystic kidney disease. Renal cystogenesis is linked to abnormal localization and function of these cystoproteins in renal primary cilia. They are
Autor:
Marcelo Marcet-Palacios, Florentina Duta, Alan D. Schreiber, Moo-Kyung Kim, A. Dean Befus, Marina Ulanova, Ulrich Steinhoff, Lakshmi Puttagunta, Zena K. Indik, Marek Duszyk
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 288:L497-L507
The protein tyrosine kinase Syk is critically involved in immunoreceptor signaling in hematopoietic cells. Recent studies demonstrate Syk expression in nonhematopoietic cells, including fibroblasts, endothelial cells, hepatocytes, and breast epitheli
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1667:241-248
Changes in the level of membrane cholesterol regulate a variety of signaling processes including those mediated by acylated signaling molecules that localize to lipid rafts. Recently several types of ion channels have been shown to have cholesterol-d
Publikováno v:
British Journal of Pharmacology. 142:531-542
Calu-3 cells have been used to investigate the actions of 4-chloro-benzo[F]isoquinoline (CBIQ) on short-circuit current (SCC) in monolayers, whole-cell recording from single cells and by patch clamping. CBIQ caused a sustained, reversible and repeata