Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marek Brodzki"'
GABAA Receptor β2E155 Residue Located at the Agonist-Binding Site Is Involved in the Receptor Gating
Autor:
Magdalena Jatczak-Śliwa, Magdalena Kisiel, Marta Magdalena Czyzewska, Marek Brodzki, Jerzy Władysław Mozrzymas
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
GABAA receptors (GABAARs) play a crucial role in mediating inhibition in the adult brain. In spite of progress in describing (mainly) the static structures of this receptor, the molecular mechanisms underlying its activation remain unclear. It is kno
Externí odkaz:
https://doaj.org/article/7dfc755e91324e2784ddfb0ea04ec34f
Autor:
Magdalena Jatczak-Śliwa, Katarzyna Terejko, Marek Brodzki, Michał A. Michałowski, Marta M. Czyzewska, Joanna M. Nowicka, Anna Andrzejczak, Rakenduvadhana Srinivasan, Jerzy W. Mozrzymas
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
GABAA receptors (GABAARs) play a crucial inhibitory role in the CNS. Benzodiazepines (BDZs) are positive modulators of specific subtypes of GABAARs, but the underlying mechanism remains obscure. Early studies demonstrated the major impact of BDZs on
Externí odkaz:
https://doaj.org/article/e4708557895a4ede8f09f34d7eab3db7
Autor:
Marek, Brodzki, Jerzy W, Mozrzymas
Publikováno v:
Life sciences. 308
GABAWe recorded micro- and macroscopic current responses of recombinant GABAMutations of this residue impaired macroscopic desensitization and accelerated current deactivation with P273E mutant showing greatest deviation from wild-type. Single-channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f92d3b8887af70a289475c893a1f071
https://pubmed.ncbi.nlm.nih.gov/36096246
https://pubmed.ncbi.nlm.nih.gov/36096246
Autor:
Marek Brodzki, Jerzy W. Mozrzymas
Publikováno v:
Life Sciences. 308:120943
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8282129d7bd903c997eae82bd7e0780f
https://doi.org/10.1016/j.lfs.2022.120943
https://doi.org/10.1016/j.lfs.2022.120943
Publikováno v:
Biochemical pharmacology. 177
GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce5dfe660e6be70b8a98456d60f0a1b1
https://pubmed.ncbi.nlm.nih.gov/32194055
https://pubmed.ncbi.nlm.nih.gov/32194055
Autor:
Jerzy W. Mozrzymas, Michal A. Michalowski, Katarzyna Terejko, Marek Brodzki, Przemyslaw Kaczor
Publikováno v:
Biophysical Journal. 121:385a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94bdaa9d0b6e6898a6f460b0c44f7732
https://doi.org/10.1016/j.bpj.2021.11.851
https://doi.org/10.1016/j.bpj.2021.11.851
Publikováno v:
Neuropharmacology. 131:453-474
GABAA receptor is the primary mediator of inhibition in the adult mammalian brain. Our recent studies revealed that a classic gating scheme for GABAAR needed to be updated with an intermediate step (flipping) and that the α1Phe64 mutation at the GAB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::110d6bed58eedc43df57bb97d5e443f4
https://doi.org/10.1016/j.neuropharm.2017.11.030
https://doi.org/10.1016/j.neuropharm.2017.11.030
Autor:
Magdalena, Jatczak-Śliwa, Magdalena, Kisiel, Marta Magdalena, Czyzewska, Marek, Brodzki, Jerzy Władysław, Mozrzymas
Publikováno v:
Frontiers in Cellular Neuroscience
GABAA receptors (GABAARs) play a crucial role in mediating inhibition in the adult brain. In spite of progress in describing (mainly) the static structures of this receptor, the molecular mechanisms underlying its activation remain unclear. It is kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62a69954d22f1354d4ac7464b64d6a4e
https://pubmed.ncbi.nlm.nih.gov/32116555
https://pubmed.ncbi.nlm.nih.gov/32116555
Autor:
Marek Brodzki, M. Kisiel, Marta M. Czyzewska, Jerzy W. Mozrzymas, Radoslaw Rutkowski, M Jatczak
Publikováno v:
European Journal of Pharmacology. 784:81-89
The fastest inhibitory mechanism in the CNS is mediated by ionotropic GABAA receptors and it is known that subunit composition critically determines their properties. While a typical GABAA receptor consists of two α, two β and one γ/δ subunit, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5533854fa7b7c53c9d952b53b5faa1
https://doi.org/10.1016/j.ejphar.2016.05.015
https://doi.org/10.1016/j.ejphar.2016.05.015
Publikováno v:
Biochemical Pharmacology. 177:113917
GABAA receptors (GABAARs) mediate inhibitory neurotransmission in the mammalian brain. Recently, numerous GABAAR static structures have been published, but the molecular mechanisms of receptor activation remain elusive. Loop G is a rigid β-strand be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bef682414137fe5ee20ca5160f9a849f
https://doi.org/10.1016/j.bcp.2020.113917
https://doi.org/10.1016/j.bcp.2020.113917