Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Marek Bartkuhn"'
Autor:
Learta Pervizaj-Oruqaj, Balachandar Selvakumar, Maximiliano Ruben Ferrero, Monika Heiner, Christina Malainou, Rolf David Glaser, Jochen Wilhelm, Marek Bartkuhn, Astrid Weiss, Ioannis Alexopoulos, Biruta Witte, Stefan Gattenlöhner, István Vadász, Rory Edward Morty, Werner Seeger, Ralph Theo Schermuly, Ana Ivonne Vazquez-Armendariz, Susanne Herold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to tissue-resident alveolar macrophages (TR-AM) in the inflamed lung. Combining high-dimensional single-cell transcriptomics
Externí odkaz:
https://doaj.org/article/78b9668d870244cca6b2f62d7f2fe96b
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 120-135 (2023)
Adaptation of bacteria to changes in their environment is often accomplished by changes of the transcriptome. While we learned a lot on the impact of transcriptional regulation in bacterial adaptation over the last decades, much less is known on the
Externí odkaz:
https://doaj.org/article/82823a1bcd1f4dd888e09bb11244b96f
Autor:
Mahsa Zabihi, Ali Khadim, Theresa M. Schäfer, Ioannis Alexopoulos, Marek Bartkuhn, Elie El Agha, Ana I. Vazquez-Armendariz, Susanne Herold
Publikováno v:
Cells, Vol 13, Iss 11, p 922 (2024)
Organoid models have become an integral part of the research methodology in the lung field. These systems allow for the study of progenitor and stem cell self-renewal, self-organization, and differentiation. Distinct models of lung organoids mimickin
Externí odkaz:
https://doaj.org/article/6f48790f13f74164b8e8b5b978d3c2e3
Autor:
Andreas Herchenröther, Stefanie Gossen, Tobias Friedrich, Alexander Reim, Nadine Daus, Felix Diegmüller, Jörg Leers, Hakimeh Moghaddas Sani, Sarah Gerstner, Leah Schwarz, Inga Stellmacher, Laura Victoria Szymkowiak, Andrea Nist, Thorsten Stiewe, Tilman Borggrefe, Matthias Mann, Joel P. Mackay, Marek Bartkuhn, Annette Borchers, Jie Lan, Sandra B. Hake
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
How the histone variant H2A.Z controls cell fate remains unclear. Here, the authors reveal that the H2A.Z interacting partner HMG20A plays a key role in regulating transcription during early head and heart development.
Externí odkaz:
https://doaj.org/article/0637b8d8470142babbb8a8e3dc3bbf4c
Autor:
Angelina M. Georgieva, Xinyue Guo, Marek Bartkuhn, Stefan Günther, Carsten Künne, Christian Smolka, Ann Atzberger, Ulrich Gärtner, Kamel Mamchaoui, Eva Bober, Yonggang Zhou, Xuejun Yuan, Thomas Braun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Utrophin is a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin. Here the authors report that inactivation of the protein deacetylase SIRT6, involved in the deacetylation of the epigenetic mark H3K56ac in muscle cells, in
Externí odkaz:
https://doaj.org/article/f98f5858e11c424f9ecb03f39cf07309
Autor:
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-9 (2022)
Abstract Notch signaling plays a pivotal role in the development and, when dysregulated, it contributes to tumorigenesis. The amplitude and duration of the Notch response depend on the posttranslational modifications (PTMs) of the activated NOTCH rec
Externí odkaz:
https://doaj.org/article/e94caf3b118449feae916a319b8e5115
Autor:
Rodrigo Diéguez-Hurtado, Katsuhiro Kato, Benedetto Daniele Giaimo, Melina Nieminen-Kelhä, Hendrik Arf, Francesca Ferrante, Marek Bartkuhn, Tobias Zimmermann, M. Gabriele Bixel, Hanna M. Eilken, Susanne Adams, Tilman Borggrefe, Peter Vajkoczy, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, i
Externí odkaz:
https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
Autor:
Stephanie Link, Ramona M. M. Spitzer, Maryam Sana, Mario Torrado, Moritz C. Völker-Albert, Eva C. Keilhauer, Thomas Burgold, Sebastian Pünzeler, Jason K. K. Low, Ida Lindström, Andrea Nist, Catherine Regnard, Thorsten Stiewe, Brian Hendrich, Axel Imhof, Matthias Mann, Joel P. Mackay, Marek Bartkuhn, Sandra B. Hake
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
PWWP2A is a chromatin-binding transcriptional regulator that mediates mitosis-progression. Here, the authors provide evidence that PWWP2A directly interacts with H2A.Z nucleosomes, DNA and H3K36me3, binds to an MTA1-specific subcomplex of the NuRD co
Externí odkaz:
https://doaj.org/article/014b47e5311d4e1aa8fa73d95eb91cdd
Autor:
Caroline Bouchard, Peeyush Sahu, Marion Meixner, René Reiner Nötzold, Marco B. Rust, Elisabeth Kremmer, Regina Feederle, Gene Hart-Smith, Florian Finkernagel, Marek Bartkuhn, Soni Savai Pullamsetti, Andrea Nist, Thorsten Stiewe, Sjaak Philipsen, Uta-Maria Bauer
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3339-3352 (2018)
Summary: Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a). This mark has been reported to associate with silent genes. Here, we use a cell model of neural differentiation, which up
Externí odkaz:
https://doaj.org/article/064477c346a2492aa5960b13e200bd05
Autor:
Theresa Jox, Melanie K. Buxa, Dorte Bohla, Ikram Ullah, Igor Mačinković, Alexander Brehm, Marek Bartkuhn, Rainer Renkawitz
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background Chromatin insulators shield promoters and chromatin domains from neighboring enhancers or chromatin regions with opposing activities. Insulator-binding proteins and their cofactors mediate the boundary function. In general, covale
Externí odkaz:
https://doaj.org/article/f345576b83d0402b8b3731b9a0cadc62