Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection.

Autor: Adrian Schmid, Sara Gianella, Viktor von Wyl, Karin J Metzner, Alexandra U Scherrer, Barbara Niederöst, Claudia F Althaus, Philip Rieder, Christina Grube, Beda Joos, Rainer Weber, Marek Fischer, Huldrych F Günthard

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13310 (2010)

Although combination antiretroviral therapy (cART) initiated in the acute phase of HIV-1 infection may prevent expansion of the latent reservoir, its benefits remain controversial. In the current study, HIV-1 RNA transcription patterns in peripheral

Externí odkaz: https://doaj.org/article/30c3590ea04d4621a9a1c60b65de29fb

Complement lysis activity in autologous plasma is associated with lower viral loads during the acute phase of HIV-1 infection.

Autor: Michael Huber, Marek Fischer, Benjamin Misselwitz, Amapola Manrique, Herbert Kuster, Barbara Niederöst, Rainer Weber, Viktor von Wyl, Huldrych F Günthard, Alexandra Trkola

Publikováno v: PLoS Medicine, Vol 3, Iss 11, p e441 (2006)

BackgroundTo explore the possibility that antibody-mediated complement lysis contributes to viremia control in HIV-1 infection, we measured the activity of patient plasma in mediating complement lysis of autologous primary virus.Methods and findingsS

Externí odkaz: https://doaj.org/article/433c20d5c6b942e0bb5e46b13b4b1d0c

Differences in HIV Burden and Immune Activation within the Gut of HIV-Positive Patients Receiving Suppressive Antiretroviral Therapy

Autor: Mark Pandori, Steven A. Yukl, Lorrie Epling, Katsuya Fujimoto, Peilin Li, Terence Ho, Amandeep K. Shergill, Alex Choi, Marek Fischer, Harry Lampiris, Joseph K. Wong, Sara Gianella, Huldrych F. Günthard, Lijie Duan, C. Bradley Hare, Kenneth R. McQuaid, Diane V. Havlir, Valerie Girling, Elizabeth Sinclair, Ashley T. Haase, Qingsheng Li

Publikováno v: The Journal of infectious diseases

Background. The gut is a major reservoir for human immunodeficiency virus (HIV) in patients receiving antiretroviral therapy (ART). We hypothesized that distinct immune environments within the gut may support varying levels of HIV.Methods. In 8 HIV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7eacf333e068fb06e092bd44e24a4b
http://doc.rero.ch/record/301653/files/202-10-1553.pdf

A Randomized Trial of Simplified Maintenance Therapy with Abacavir, Lamivudine, and Zidovudine in Human Immunodeficiency Virus Infection

Autor: Enos Bernasconi, Hansjakob Furrer, Milos Opravil, Sabine Yerly, Rainer Weber, Marek Fischer, Huldrych F. Günthard, Bernard Hirschel, Leslie R. Bisset, Colin Howe, Manuel Battegay, Jean Philippe Chave, Pietro Vernazza, Bruno Ledergerber, Adriano Lazzarin, Luc Perrin

Publikováno v: Opravil, Milos; Hirschel, Bernard; Lazzarin, Adriano; Furrer, Hansjakob; Chave, Jean-Philippe; Yerly, Sabine; Bisset, Leslie R.; Fischer, Marek; Vernazza, Pietro; Bernasconi, Enos; Battegay, Manuel; Ledergerber, Bruno; Günthard, Huldrych; Howe, Colin; Weber, Rainer; Perrin, Luc (2002). A Randomized Trial of Simplified Maintenance Therapy with Abacavir, Lamivudine, and Zidovudine in Human Immunodeficiency Virus Infection. Journal of infectious diseases, 185(9), pp. 1251-1260. The University of Chicago Press 10.1086/340312
The Journal of Infectious Diseases, Vol. 185, No 9 (2002) pp. 1251-1260

This randomized study evaluated the efficacy and tolerability of continued treatment with protease inhibitor plus nucleoside-analogue combination regimens (n = 79) or a change to the simplified regimen of abacavir-lamivudine-zidovudine (n = 84) in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ae535520469334e4699c267e1912b4
http://doc.rero.ch/record/303577/files/185-9-1251.pdf

Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy

Autor: Marek Fischer, Huldrych F. Günthard, Annette Oxenius, Christine Schneider, Sarah J. Dawson, Angela R. McLean, Rainer Weber, Roland Hafner, Bernard Hirschel, Helen Joller, Rodney E. Phillips, David Price

Publikováno v: Journal of Virology, Vol. 76, No 20 (2002) pp. 10169-10176

There is a continuing search for better ways to use existing drugs against human immunodeficiency virus (HIV). One idea is to use short therapy interruptions to “autovaccinate” HIV-infected patients. A group of 13 chronically HIV-infected patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f96022146b41dcc240e25fde5d33c3
https://ora.ox.ac.uk/objects/uuid:572185b1-0674-4eff-ad10-944c4ef85259