Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Mareike Florek"'
Autor:
Yuqiong Pan, Dennis B. Leveson-Gower, Patricia E. de Almeida, Antonio Pierini, Jeanette Baker, Mareike Florek, Hidekazu Nishikii, Byung-Su Kim, Rong Ke, Joseph C. Wu, Robert S. Negrin
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1793-1802 (2015)
Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as well as
Externí odkaz:
https://doaj.org/article/e334f832edb34799adb0da200b0b04dd
Autor:
Mareike Florek, Dominik Schneidawind, Antonio Pierini, Jeanette Baker, Randall Armstrong, Yuqiong Pan, Dennis Leveson-Gower, Robert Negrin, Everett Meyer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145763 (2015)
The adoptive transfer of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in murine models of allogeneic hematopoietic cell transplantation (HCT) has been shown to protect recipient mice from lethal acute graft-versus-host disease (GVHD) and this approach
Externí odkaz:
https://doaj.org/article/0494293a86734c18912e497446202cb7
Autor:
Emanuela I Sega, Dennis B Leveson-Gower, Mareike Florek, Dominik Schneidawind, Richard H Luong, Robert S Negrin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86551 (2014)
Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cel
Externí odkaz:
https://doaj.org/article/a0faece07ceb4400b242bf8d6059b24b
Autor:
Robert S. Negrin, Alexander Filatenkov, Antonia M.S. Müller, Mareike Florek, Judith A. Shizuru, Natascha J. Küpper, Jessica A. Linderman, Holbrook E Kohrt, Husein Hadeiba
Publikováno v:
The Journal of Immunology. 197:4151-4162
T cells are widely used to promote engraftment of hematopoietic stem cells (HSCs) during an allogeneic hematopoietic cell transplantation. Their role in overcoming barriers to HSC engraftment is thought to be particularly critical when patients recei
Autor:
Dullei Min, Robert B. Levy, Gerlinde Wernig, Mareike Florek, Judith A. Shizuru, Victor L. Perez, Samantha Herretes, Casey Burnett, Antonia M.S. Müller, Kenneth Weinberg
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 25(12)
Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation. Acute GVHD (aGVHD) results from direct damage by donor T cells, whereas the biology of chronic GVHD (cGVHD) with its autoimmune-like manif
Autor:
Hidekazu Nishikii, Byung Su Kim, Maite Alvarez, Yuqiong Pan, Antonio Pierini, Dominik Schneidawind, Jeanette Baker, Lucrezia Colonna, Robert S. Negrin, Mareike Florek
Publikováno v:
The Journal of Immunology. 195:347-355
Adoptive transfer of freshly isolated natural occurring CD4+CD25+Foxp3+ regulatory T cells (Treg) prevents graft-versus-host disease (GVHD) in several animal models and following hematopoietic cell transplantation (HCT) in clinical trials. Donor-deri
Autor:
Jeanette Baker, Antonio Pierini, Yuqiong Pan, Dennis B. Leveson-Gower, Robert S. Negrin, Mareike Florek, Hidekazu Nishikii, Patrícia de Almeida, Joseph C. Wu, Byung-Su Kim, Rong Ke
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1793-1802 (2015)
Summary Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as
Autor:
David Ritchie, Saar Gill, Aaron Smith, Jeanette Baker, Alysha De Souza, Robert S. Negrin, Mareike Florek, Adrianne E Vasey, Keri Tate, Holbrook E Kohrt, Kenneth D. Gibbs
Publikováno v:
Blood. 119:5758-5768
Natural killer (NK) cells are potent anti-viral and antitumor “first responders” endowed with natural cytotoxicity and cytokine production capabilities. To date, attempts to translate these promising biologic functions through the adoptive transf
Autor:
Robert S. Negrin, Robert Lowsky, David B. Miklos, Laura Johnston, Sally Arai, Mareike Florek, Judith A. Shizuru, Janice M. Brown, Philip W. Lavori, K Sheehan, J S McCune, Randall Armstrong, Ginna G. Laport
Publikováno v:
Bone marrow transplantation
We investigated sirolimus and mycophenolate mofetil (MMF) as GVHD prophylaxis in patients with advanced hematological malignancies receiving myeloablative hematopoietic cell transplantation (HCT) from HLA-identical sibling donors. On the basis of pre
Autor:
Antonia M.S. Müller, Mareike Florek, Jessica A. Linderman, Judith A. Shizuru, David B. Miklos
Publikováno v:
Proceedings of the National Academy of Sciences. 107:14721-14726
Because of the perception that depleting hematopoietic grafts of T cells will result in poorer immune recovery and in increased risk of graft rejection, pure hematopoietic stem cells (HSC), which avoid the potentially lethal complication of graft-ver