Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mardelle Atkins"'
Autor:
Swann Floc'hlay, Ramya Balaji, Dimitrije Stanković, Valerie M Christiaens, Carmen Bravo González-Blas, Seppe De Winter, Gert J Hulselmans, Maxime De Waegeneer, Xiaojiang Quan, Duygu Koldere, Mardelle Atkins, Georg Halder, Mirka Uhlirova, Anne-Kathrin Classen, Stein Aerts
Publikováno v:
eLife, Vol 12 (2023)
Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migrati
Externí odkaz:
https://doaj.org/article/466fad16d6af41f0a02156a24ebcaa84
Autor:
Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan, Jan Cools
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Background The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). Methods Here, we
Externí odkaz:
https://doaj.org/article/d2b4f3970332452b81f7d13001aa3d14
Autor:
Fisun Hamaratoglu, Mardelle Atkins
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4580 (2020)
Can hyperactivation of a few key signaling effectors be the underlying reason for the majority of epithelial cancers despite different driver mutations? Here, to address this question, we use the Drosophila model, which allows analysis of gene expres
Externí odkaz:
https://doaj.org/article/6edee9baee404053ba06331ed165825f
Autor:
Kristofer Davie, Jelle Jacobs, Mardelle Atkins, Delphine Potier, Valerie Christiaens, Georg Halder, Stein Aerts
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004994 (2015)
Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically de
Externí odkaz:
https://doaj.org/article/06c04a5555414c05a03f1378b8b54139
Autor:
Mardelle Atkins, Yuwei Jiang, Leticia Sansores-Garcia, Barbara Jusiak, Georg Halder, Graeme Mardon
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003731 (2013)
Organ development is directed by selector gene networks. Eye development in the fruit fly Drosophila melanogaster is driven by the highly conserved selector gene network referred to as the "retinal determination gene network," composed of approximate
Externí odkaz:
https://doaj.org/article/f771c912e3464b82a3325fac430245ab
Autor:
Swann Floc’hlay, Ramya Balaji, Valerie Christiaens, Carmen Bravo González-Blas, Seppe De Winter, Gert Hulselmans, Maxime De Waegeneer, Xiaojiang Quan, Duygu Koldere, Mardelle Atkins, Georg Halder, Anne Classen, Stein Aerts
Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs including apoptosis, proliferation, and cell migratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d8fba0589e2fbffab2a79e8d061d13c
https://doi.org/10.1101/2022.06.17.496596
https://doi.org/10.1101/2022.06.17.496596
Autor:
Mardelle Atkins, Fisun Hamaratoglu
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4580, p 4580 (2020)
Volume 21
Issue 13
International Journal of Molecular Sciences, Vol 21, Iss 4580, p 4580 (2020)
Volume 21
Issue 13
Can hyperactivation of a few key signaling effectors be the underlying reason for the majority of epithelial cancers despite different driver mutations? Here, to address this question, we use the Drosophila model, which allows analysis of gene expres
Publikováno v:
Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye ISBN: 9783030422455
Cancer is a devastating disease resulting from uncontrolled cell proliferation producing tumors and invasion/metastasis of cells resulting in secondary tumors. The underlying genetic defects occur in oncogenes and tumor suppressor genes and in genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52f7ef21670acb46cfa18e6a0db46101
https://doi.org/10.1007/978-3-030-42246-2_9
https://doi.org/10.1007/978-3-030-42246-2_9
Autor:
Leticia Sansores-Garcia, Kathleen M Gajewski, Robert Andrew Mills, Leen Van Huffel, Mardelle Atkins, Violaine Mottier-Pavie, Jana Mach, Weronika Kowalczyk, Jun Xie, Georg Halder, Gordon B. Mills
Publikováno v:
Proceedings of the National Academy of Sciences. 115:10684-10689
The Hippo tumor-suppressor pathway regulates organ growth, cell proliferation, and stem cell biology. Defects in Hippo signaling and hyperactivation of its downstream effectors-Yorkie (Yki) in Drosophila and YAP/TAZ in mammals-result in progenitor ce
Autor:
Mardelle, Atkins
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1893
Drosophila melanogaster has been a central player in the discovery of the Hippo pathway and in understanding its in vivo functions. From a technique standpoint, the Flp-FRT system for the generation of genetic mosaics has been a principle tool. It ha