Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marcy R. Weatherspoon"'
Autor:
David M. Yurek, Anita M. Fletcher, Matthew McShane, Tomasz H. Kowalczyk, Linas Padegimas, Marcy R. Weatherspoon, Michael D. Kaytor, Mark J. Cooper, Assem G. Ziady
Publikováno v:
Molecular Imaging, Vol 10 (2011)
In this study, we used bioluminescence imaging (BLI) to track long-term transgene activity following the transfection of brain cells using a nonviral gene therapy technique. Formulations of deoxyribonucleic acid (DNA) combined with 30-mer lysine poly
Externí odkaz:
https://doaj.org/article/74fd1eaad961438ba622f377fd517651
Autor:
Michael D. Kaytor, Zhiming Zhang, Yi Ai, Peter T. Nelson, Richard Grondin, Deepak R. Thakker, William F. Kaemmerer, Marcy R. Weatherspoon, Jennifer M. Heisel, Eric N. Burright, Janelle L. Blum
Publikováno v:
Brain
Huntington's disease is caused by expression of a mutant form of Huntingtin protein containing an expanded polyglutamine repeat. One possible treatment for Huntington's disease may be to reduce expression of mutant Huntingtin in the brain via RNA int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b204c23054f002e86e2c87b2169fb3
https://doi.org/10.1093/brain/awr333
https://doi.org/10.1093/brain/awr333
Autor:
Roy Haskell, Jennifer M. Heisel, Charles F. Albright, Maria Pierdomenico, Marcy R. Weatherspoon, Lisa L. Shafer, Sarah J. Taylor, Lorin A. Thompson, Deepak R. Thakker, James E. Grace, Jonathan Harrison, Sethu Sankaranarayanan
Multiple small-molecule inhibitors of the β-secretase enzyme (BACE1) are under preclinical or clinical investigation for Alzheimer's disease (AD). Prior work has illustrated robust lowering of central amyloid β (Aβ) after acute administration of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4c4edeaab1357dd79e472768c7e653
https://europepmc.org/articles/PMC6605183/
https://europepmc.org/articles/PMC6605183/
Autor:
John W. Day, Gang Chen, Laura P.W. Ranum, Marcy R Weatherspoon, Wangcai Gao, Yoshio Ikeda, Anne K Mosemiller, Randy S. Daughters, Timothy J. Ebner, H. Brent Clark, Tao Zu, Melinda L. Moseley
Publikováno v:
Nature Genetics. 38:758-769
We previously reported that a (CTG)n expansion causes spinocerebellar ataxia type 8 (SCA8), a slowly progressive ataxia with reduced penetrance. We now report a transgenic mouse model in which the full-length human SCA8 mutation is transcribed using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037731aa8ddd887387ddf7f0a163e554
https://doi.org/10.1038/ng1827
https://doi.org/10.1038/ng1827
Autor:
H. Brent Clark, Alexis Brice, Marcy R Weatherspoon, Katrin Bürk, Dan Gincel, John W. Day, Katherine A. Dick, Karen R Armbrust, Giovanni Stevanin, Lawrence J. Schut, Joline C. Dalton, Laura P.W. Ranum, Alexandra Durr, Christine Zühlke, Yoshio Ikeda, Jeffrey D. Rothstein
Publikováno v:
Nature Genetics. 38:184-190
We have discovered that beta-III spectrin (SPTBN2) mutations cause spinocerebellar ataxia type 5 (SCA5) in an 11-generation American kindred descended from President Lincoln's grandparents and two additional families. Two families have separate in-fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc38dc15c4814a29ee6d5491f3386b2
https://doi.org/10.1038/ng1728
https://doi.org/10.1038/ng1728
Autor:
Michael D. Kaytor, Matthew McShane, Assem G. Ziady, Marcy R. Weatherspoon, Anita M. Fletcher, David M. Yurek, Tomasz Kowalczyk, Linas Padegimas, Mark J. Cooper
Publikováno v:
Molecular Imaging, Vol 10 (2011)
In this study, we used bioluminescence imaging (BLI) to track long-term transgene activity following the transfection of brain cells using a nonviral gene therapy technique. Formulations of deoxyribonucleic acid (DNA) combined with 30-mer lysine poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37d568b091b48f9ab2e39047a21fd3d
https://doaj.org/article/74fd1eaad961438ba622f377fd517651
https://doaj.org/article/74fd1eaad961438ba622f377fd517651
Autor:
Gregory R. Stewart, Charles F. Albright, Jennifer M. Heisel, Roy Haskell, Maria Pierdomenico, Marcy R. Weatherspoon, Bradley Nix, Sethu Sankaranarayanan, James E. Grace, Lisa L. Shafer, Deepak R. Thakker, Lorin A. Thompson, Jonathan Harrison, Sarah J. Taylor
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c89007ad3f63cc874c586a8478db2efb
https://doi.org/10.1016/j.jalz.2011.05.1377
https://doi.org/10.1016/j.jalz.2011.05.1377
Autor:
Marcy R. Weatherspoon, Lisa L. Shafer, Thomas Keene, Jonathan Harrison, Deepak R. Thakker, William F. Kaemmerer, Deanna S. Lane, Gregory R. Stewart
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(11)
Although immunization against amyloid-β (Aβ) holds promise as a disease-modifying therapy for Alzheimer disease (AD), it is associated with an undesirable accumulation of amyloid in the cerebrovasculature [i.e., cerebral amyloid angiopathy (CAA)] a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f80593f5bad1aac6dc8fcbdea321102
https://pubmed.ncbi.nlm.nih.gov/19246392
https://pubmed.ncbi.nlm.nih.gov/19246392
Myotonic Dystrophy Type 2: Human Founder Haplotype and Evolutionary Conservation of the Repeat Tract
Autor:
John W. Day, Joline C. Dalton, Christina L. Liquori, Laura P.W. Ranum, Yoshio Ikeda, Kenneth Ricker, Benedikt Schoser, Marcy R Weatherspoon
Myotonic dystrophy (DM), the most common form of muscular dystrophy in adults, can be caused by a mutation on either chromosome 19 (DM1) or 3 (DM2). In 2001, we demonstrated that DM2 is caused by a CCTG expansion in intron 1 of the zinc finger protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a579d7bd13390a51eca25a8a7c3bcadb
https://europepmc.org/articles/PMC1180607/
https://europepmc.org/articles/PMC1180607/
Autor:
Linnea Lentz, Marty Morris, Tina Billstrom, Marcy R. Weatherspoon, Jack Keimel, William F. Kaemmerer, Katie Green, Eric N. Burright
Publikováno v:
Molecular Genetics and Metabolism. 99:S38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15026370816b6d9b703cf2ce151a484e
https://doi.org/10.1016/j.ymgme.2009.10.162
https://doi.org/10.1016/j.ymgme.2009.10.162