Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marcy Martin"'
Autor:
Nikolaos Poulis, Marcy Martin, Simon P. Hoerstrup, Maximilian Y. Emmert, Emanuela S. Fioretta
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Upon implanting tissue-engineered heart valves (TEHVs), blood-derived macrophages are believed to orchestrate the remodeling process. They initiate the immune response and mediate the remodeling of the TEHV, essential for the valve’s funct
Externí odkaz:
https://doaj.org/article/27d70931dcc6456c819bf6d5a29a7374
Autor:
Nikolaos Poulis, Marcy Martin, Simon P. Hoerstrup, Maximilian Y. Emmert, Emanuela S. Fioretta
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
In situ heart valve tissue engineering approaches have been proposed as promising strategies to overcome the limitations of current heart valve replacements. Tissue engineered heart valves (TEHVs) generated from in vitro grown tissue engineered matri
Externí odkaz:
https://doaj.org/article/9670adf16eba4c35b56687aefb37d8c1
Autor:
Marcy Martin, Eric K. N. Gähwiler, Melanie Generali, Simon P. Hoerstrup, Maximilian Y. Emmert
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5188 (2023)
The adult human heart cannot regain complete cardiac function following tissue injury, making cardiac regeneration a current clinical unmet need. There are a number of clinical procedures aimed at reducing ischemic damage following injury; however, i
Externí odkaz:
https://doaj.org/article/327b0a60862643cc9a82ab3a51d4283b
Autor:
Marcy Martin, Jiao Zhang, Yifei Miao, Ming He, Jian Kang, Hsi-Yuan Huang, Chih-Hung Chou, Tse-Shun Huang, Hsiao-Chin Hong, Shu-Han Su, Simon S. Wong, Rebecca L. Harper, Lingli Wang, Rakesh Bhattacharjee, Hsien-Da Huang, Zhen Bouman Chen, Atul Malhotra, Marlene Rabinovitch, James S. Hagood, John Y-J. Shyy
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited treatment options. Despite endothelial cells (ECs) comprising 30% of the lung cellular composition, the role of EC dysfunction in pulmonary fibrosis (PF) remains unclear.
Externí odkaz:
https://doaj.org/article/a987127f94c64dac82b05abf54e1a92c
Autor:
Eric K. N. Gähwiler, Sarah E. Motta, Marcy Martin, Bramasta Nugraha, Simon P. Hoerstrup, Maximilian Y. Emmert
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field achieved significant milestones and opened several gateways in t
Externí odkaz:
https://doaj.org/article/4b7bf127de5a4be99477cb1aa07463e1
Publikováno v:
APL Bioengineering, Vol 4, Iss 1, Pp 010904-010904-8 (2020)
Lining the luminal surface of the vasculature, endothelial cells (ECs) are in direct contact with and differentially respond to hemodynamic forces depending on their anatomic location. Pulsatile shear stress (PS) is defined by laminar flow and is pre
Externí odkaz:
https://doaj.org/article/d17feff74c5f4db5a4671a2d48c1ddfa
Autor:
Sarah E Motta, Marcy Martin, Eric K N Gähwiler, Valery L Visser, Polina Zaytseva, Arian Ehterami, Simon P Hoerstrup, Maximilian Y Emmert
Publikováno v:
Stem Cells Translational Medicine, 12 (2)
Cardiovascular disease is a major cause of morbidity and mortality worldwide and, to date, the clinically available prostheses still present several limitations. The design of next-generation regenerative replacements either based on cellular or extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba9e02bbb8753b68c1463ec9ead2f9f
https://hdl.handle.net/20.500.11850/602762
https://hdl.handle.net/20.500.11850/602762
Autor:
Wei Sun, Jie Li, Po Hsun Huang, Marcy Martin, Ming He, Shu Chien, Lili Chen, Traci Marin, Shen-Chih Wang, Yue Han, Shanshan Chen, Jiao Zhang, Brendan Gongol, Christian Lytle, John Y.-J. Shyy, David A. Johnson, Jian Kang, Yi Shuan Li, Jun Hui Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 26
Pulsatile shear (PS) and oscillatory shear (OS) elicit distinct mechanotransduction signals that maintain endothelial homeostasis or induce endothelial dysfunction, respectively. A subset of microRNAs (miRs) in vascular endothelial cells (ECs) are di
Autor:
Marlene Rabinovitch, Joseph C. Wu, Lei Tian, Marcy Martin, Mingxia Gu, Paul Grossfeld, Shuyi Nie, Yifei Miao, Francisco X Galdos, Timothy J. Nelson, Soah Lee, Seema Mital, Sharon L. Paige, Sean M. Wu
Publikováno v:
Circulation. 142
Hypoplastic left heart syndrome (HLHS) is one of the most challenging forms of congenital heart diseases. Previous studies were mainly focused on intrinsic defects in myocardium. However, this does not sufficiently explain the abnormal development of
Publikováno v:
Circulation Research. 127
Hypoplastic left heart syndrome (HLHS) is a single ventricle congenital heart disease that results in severe underdevelopment of the left ventricle, mitral valve, aortic valve, and ascending aorta. Early serial postmortem examinations also revealed a