Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Marcus Thelen"'
Autor:
Edisa Pirani, Philipp Paparoditis, Matteo Pecoraro, Gabriela Danelon, Marcus Thelen, Valentina Cecchinato, Mariagrazia Uguccioni
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
During inflammation and tissue regeneration, the alarmin High Mobility Group Box 1 (HMGB1), in its reduced isoform, enhances the activity of the chemokine CXCL12, forming a heterocomplex that acts via the chemokine receptor CXCR4. Despite the establi
Externí odkaz:
https://doaj.org/article/3c6a82bb253c4474a381a38b9fc727de
Autor:
Alain Pulfer, Diego Ulisse Pizzagalli, Paolo Armando Gagliardi, Lucien Hinderling, Paul Lopez, Romaniya Zayats, Pau Carrillo-Barberà, Paola Antonello, Miguel Palomino-Segura, Benjamin Grädel, Mariaclaudia Nicolai, Alessandro Giusti, Marcus Thelen, Luca Maria Gambardella, Thomas T Murooka, Olivier Pertz, Rolf Krause, Santiago Fernandez Gonzalez
Publikováno v:
eLife, Vol 12 (2024)
Intravital microscopy has revolutionized live-cell imaging by allowing the study of spatial–temporal cell dynamics in living animals. However, the complexity of the data generated by this technology has limited the development of effective computat
Externí odkaz:
https://doaj.org/article/7e7d13c61fdf4ad4b1ddfbc78e28f7a6
Autor:
Paola Antonello, Diego Morone, Edisa Pirani, Mariagrazia Uguccioni, Marcus Thelen, Rolf Krause, Diego Ulisse Pizzagalli
Publikováno v:
Journal of Biological Engineering, Vol 17, Iss 1, Pp 1-10 (2023)
Abstract Cell migration is a pivotal biological process, whose dysregulation is found in many diseases including inflammation and cancer. Advances in microscopy technologies allow now to study cell migration in vitro, within engineered microenvironme
Externí odkaz:
https://doaj.org/article/49cd18ddcc744d079349a41959779dbe
Autor:
Serena Melgrati, Oliver J. Gerken, Marc Artinger, Egle Radice, Martyna Szpakowska, Andy Chevigné, Giulia D’Uonnolo, Paola Antonello, Sylvia Thelen, Pawel Pelczar, Daniel F. Legler, Marcus Thelen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating
Externí odkaz:
https://doaj.org/article/9970cfc4f4c44b67969d20b2bd45a28c
Autor:
Serena Melgrati, Egle Radice, Rafet Ameti, Elin Hub, Sylvia Thelen, Pawel Pelczar, David Jarrossay, Antal Rot, Marcus Thelen
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002111 (2023)
Atypical chemokine receptors (ACKRs) scavenge chemokines and can contribute to gradient formation by binding, internalizing, and delivering chemokines for lysosomal degradation. ACKRs do not couple to G-proteins and fail to induce typical signaling i
Externí odkaz:
https://doaj.org/article/db3daf668bb049ca8e1f22c49ababbe0
Autor:
Martyna Szpakowska, Giulia D’Uonnolo, Rafael Luís, Ana Alonso Bartolomé, Marcus Thelen, Daniel F. Legler, Andy Chevigné
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands. They do, however, play a crucial regulatory role in chemokine biology by capturing, sca
Externí odkaz:
https://doaj.org/article/8e49bcf050c243f79bcc7daea35cb726
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/f1a6db2b49f8478db0bbd6ed867fc44c
Autor:
Elena C Sigmund, Aline Bauer, Barbara D Jakobs, Hazal Tatliadim, Carlotta Tacconi, Marcus Thelen, Daniel F Legler, Cornelia Halin
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285597 (2023)
Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) an
Externí odkaz:
https://doaj.org/article/f9990a6da99c47a399804317fc973bdc
ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production
Autor:
Paola Antonello, Diego U. Pizzagalli, Mathilde Foglierini, Serena Melgrati, Egle Radice, Sylvia Thelen, Marcus Thelen
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphom
Externí odkaz:
https://doaj.org/article/82691c7cee7b459e96d494009acf3c8b
Autor:
Aliza T. Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L. Kieffer
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known abou
Externí odkaz:
https://doaj.org/article/c691042905314379a42058d6da6d43ec