Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Marcus Semtner"'
Autor:
Nine Kompier, Marcus Semtner, Sophie Walter, Natali Kakabadze, Christian Steinhäuser, Christiane Nolte, Helmut Kettenmann
Publikováno v:
Current Research in Neurobiology, Vol 7, Iss , Pp 100137- (2024)
We established a longitudinal acute slice preparation of transgenic mouse optic nerve to characterize membrane properties and coupling of glial cells by patch-clamp and dye-filling, complemented by immunohistochemistry. Unlike in cortex or hippocampu
Externí odkaz:
https://doaj.org/article/442aab50b1714340a191a36b1ddd9ebb
Autor:
Olga Bakina, Thomas Conrad, Nina Mitic, Ramon Oliveira Vidal, Tessa Obrusnik, Somesh Sai, Christiane Nolte, Marcus Semtner, Helmut Kettenmann
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0302376 (2024)
We applied the patch-seq technique to harvest transcripts from individual microglial cells from cortex, hippocampus and corpus callosum of acute brain slices from adult mice. After recording membrane currents with the patch-clamp technique, the cytop
Externí odkaz:
https://doaj.org/article/61b465e893fe4280b1983c231088bfe2
Autor:
Leonard D. Kuhrt, Edyta Motta, Nirmeen Elmadany, Hannah Weidling, Raphaela Fritsche-Guenther, Ibrahim E. Efe, Olivia Cobb, Jit Chatterjee, Lucy G. Boggs, Marina Schnauß, Sebastian Diecke, Marcus Semtner, Corina Anastasaki, David H. Gutmann, Helmut Kettenmann
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/27ffcc79016247599283cd70ac5c43af
Autor:
Francesca Logiacco, Laura Cathleen Grzegorzek, Elizabeth C. Cordell, Oliver Popp, Philipp Mertins, David H. Gutmann, Helmut Kettenmann, Marcus Semtner
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract We previously discovered a sex-by-genotype defect in microglia function using a heterozygous germline knockout mouse model of Neurofibromatosis type 1 (Nf1 ± mice), in which only microglia from male Nf1 ± mice exhibited defects in purinerg
Externí odkaz:
https://doaj.org/article/9d5a9756881946f5958a17392cf3aabf
Autor:
Steffen Fricke, Magnus Harnau, Florian Hetsch, Haoran Liu, Julia Leonhard, Anna Eylmann, Pina Knauff, Han Sun, Marcus Semtner, Jochen C. Meier
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The monovalent cations sodium and potassium are crucial for the proper functioning of excitable cells, but, in addition, other monovalent alkali metal ions such as cesium and lithium can also affect neuronal physiology. For instance, there have been
Externí odkaz:
https://doaj.org/article/c6e55ab9c8504a9b94c27eea153f2d6d
Autor:
Verena Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Perez Hernandez, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent Magrini, Amy Ly, Jason Walker, Elaine Mardis, Philipp Mertins, Sascha Sauer, Helmut Kettenmann, David H. Gutmann
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-4 (2020)
The original publication of this article [1] contained 3 minor errors in Figs. 1, 3 and 5. In this correction article the updated figures are published. The figure captions describe the updated information in these figures.
Externí odkaz:
https://doaj.org/article/654d2c78a6024ca38b233dd357d32db9
Autor:
Verena Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Perez Hernandez, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent Magrini, Amy Ly, Jason Walker, Elaine Mardis, Philipp Mertins, Sascha Sauer, Helmut Kettenmann, David H. Gutmann
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Monocytes/macrophages have begun to emerge as key cellular modulators of brain homeostasis and central nervous system (CNS) disease. In the healthy brain, resident microglia are the predominant macrophage cell population; however, under cond
Externí odkaz:
https://doaj.org/article/986b937012e84a5e90276262cfb94f49
Autor:
Nirmeen Elmadany, Francesca Logiacco, Alice Buonfiglioli, Verena C. Haage, Elizabeth C. Wright-Jin, Alexander Schattenberg, Roxane M. Papawassiliou, Helmut Kettenmann, Marcus Semtner, David H. Gutmann
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105030- (2020)
As critical regulators of brain homeostasis, microglia are influenced by numerous factors, including sex and genetic mutations. To study the impact of these factors on microglia biology, we employed genetically engineered mice that model Neurofibroma
Externí odkaz:
https://doaj.org/article/9e0770fe1b7e43c2bbca4f9a3728af3b
let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7
Autor:
Alice Buonfiglioli, Ibrahim E. Efe, Dilansu Guneykaya, Andranik Ivanov, Yimin Huang, Elisabeth Orlowski, Christina Krüger, Rudolf A. Deisz, Darko Markovic, Charlotte Flüh, Andrew G. Newman, Ulf C. Schneider, Dieter Beule, Susanne A. Wolf, Omar Dzaye, David H. Gutmann, Marcus Semtner, Helmut Kettenmann, Seija Lehnardt
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3460-3471.e7 (2019)
Summary: Microglia express Toll-like receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, let-7 microRNA (miRNA) family members are abundantly expressed, and some have recently been shown to ser
Externí odkaz:
https://doaj.org/article/315937f3f37d472cb69afef13d6d3ebb
Autor:
Niklas Meyer, Nadine Richter, Zoya Fan, Gabrielle Siemonsmeier, Tatyana Pivneva, Philipp Jordan, Christian Steinhäuser, Marcus Semtner, Christiane Nolte, Helmut Kettenmann
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2383-2394 (2018)
Summary: In the optic nerve, oligodendrocytes maintain axonal function by supplying lactate as an energy substrate. Here, we report that, in acute brain slices of the mouse corpus callosum, exogenous glucose deprivation (EGD) abolished compound actio
Externí odkaz:
https://doaj.org/article/7c5d68a27dee4c798bc33a8ac6287001