Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Marcus Schewe"'
1
Akademický článek
Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2
Autor: Lea C. Neelsen, Elena B. Riel, Susanne Rinné, Freya-Rebecca Schmid, Björn C. Jürs, Mauricio Bedoya, Jan P. Langer, Bisher Eymsh, Aytug K. Kiper, Sönke Cordeiro, Niels Decher, Thomas Baukrowitz, Marcus Schewe
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Two-pore domain K+ (K2P) channel activity was previously thought to be controlled primarily via a selectivity filter (SF) gate. However, recent crystal structures of TASK-1 and TASK-2 revealed a lower gate at the cytoplasmic pore entrance. H
Externí odkaz: https://doaj.org/article/24e90c44b7b6404d984bf10fe4b40d18
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2
Akademický článek
Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
Autor: Berke Türkaydin, Marcus Schewe, Elena Barbara Riel, Friederike Schulz, Johann Biedermann, Thomas Baukrowitz, Han Sun
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The two-pore domain potassium (K2P) channels TREK-1 and TREK-2 link neuronal excitability to a variety of stimuli including mechanical force, lipids, temperature and phosphorylation. This regulation involves the C-terminus as a polymodal sti
Externí odkaz: https://doaj.org/article/5619ce0d50534cba80d1c6194a89ea85
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3
Akademický článek
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
Autor: Karin E. J. Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H. M. Smith, Ashley C. W. Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R. Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J. Owens, Simon Newstead, Jan Steyaert, Elisabeth P. Carpenter, Stephen J. Tucker
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play crucial roles in controlling the electrical activity of many different cell types and represent attractive therapeutic targets. However, the identification of high
Externí odkaz: https://doaj.org/article/9ac3923cca8e4d1e92ffe481cfd471bf
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4
Akademický článek
Sodium permeable and 'hypersensitive' TREK‐1 channels cause ventricular tachycardia
Autor: Niels Decher, Beatriz Ortiz‐Bonnin, Corinna Friedrich, Marcus Schewe, Aytug K Kiper, Susanne Rinné, Gunnar Seemann, Rémi Peyronnet, Sven Zumhagen, Daniel Bustos, Jens Kockskämper, Peter Kohl, Steffen Just, Wendy González, Thomas Baukrowitz, Birgit Stallmeyer, Eric Schulze‐Bahr
Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 4, Pp 403-414 (2017)
Abstract In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K2P potassium channel TREK‐1 (KCNK2 or K2P2.1). This mutation introduces
Externí odkaz: https://doaj.org/article/9640f01ff7df45b1a9d350a18cebee9f
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5
Akademický článek
The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels
Autor: Susanne Rinné, Aytug K Kiper, Kirsty S Vowinkel, David Ramírez, Marcus Schewe, Mauricio Bedoya, Diana Aser, Isabella Gensler, Michael F Netter, Phillip J Stansfeld, Thomas Baukrowitz, Wendy Gonzalez, Niels Decher
Publikováno v: eLife, Vol 8 (2019)
Two-pore-domain potassium (K2P) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs prefere
Externí odkaz: https://doaj.org/article/9178c14d8086419a86795f2382cf020d
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9
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism
Autor: Elena B. Riel, Björn C. Jürs, Sönke Cordeiro, Marianne Musinszki, Marcus Schewe, Thomas Baukrowitz
Publikováno v: Journal of General Physiology. 154
Work over the past three decades has greatly advanced our understanding of the regulation of Kir K+ channels by polyanionic lipids of the phosphoinositide (e.g., PIP2) and fatty acid metabolism (e.g., oleoyl-CoA). However, comparatively little is kno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3000a059394dcc03e04789b8ff318e
https://doi.org/10.1085/jgp.202112989
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